Conserved Protein Domain Family
Tmemb_55A

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pfam09788: Tmemb_55A 
Transmembrane protein 55A
Members of this family catalyze the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
Statistics
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PSSM-Id: 462901
Aligned: 17 rows
Threshold Bit Score: 330.523
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006013160   6 VDERSPLLsapns--gnvtpT---APTYIS----------ENS-------PRA----------------------ELPPP 41 
XP_015781621   7 TDENQPLLg----------aVggvETTNGSng------drWKP-------PKSevyvrpa---------dssytsDGPPA 54 
Q2LZQ8         3 DPERQSLInkde----simyTssaAVDEGA----------ENP-------GSStaavpnedgngaptavpcigpdELPPP 61  Drosophila pseu...
2_pfamImport   1 QEEKKPLLpyds----ksnySansATATSN--------------------GQTtvsp--------------igpdELPPS 42 
XP_011145409   6 EGERQPLLknen-----vtySshgSDAFEE--------------------SQStvntvs-----------tigpdELPPP 49 
Q16QP8         4 ESEKQPLLkq---------sSqsgQPDSGS--------------------EQPsqaivta---------ssigpdEVPPP 45  yellow fever mo...
Q66I51         3 DGERSPLLldgr--------dgmtGLSLGDepy----rpiSKPqnf-avfPSAppm-----------------lgEAPPP 52  zebrafish
4_pfamImport   1 DGERSPLLpeqrdgangvspG---GGSLGYfkypagvirpSSPlhvlfppPRSfpvcht-----------pvaagEPPPP 66 
CAG02185       3 DPERSPLLsehhdgtngfspG---GSYYGYp---------PKPqtl-apfPASvv------------------laEPPPP 51  spotted green p...
XP_316310      4 ESEKQPLLkq---------aAqqqSQESGS--------------------VQPvvnas------------pigpdEVPPS 42  Anopheles gambi...
XP_006013160  42 YTAIASPDAG-GVPVINCRVCQSLINLDGKLHQHVVKCTICNEATPIKNPPAGKKYVRCPCNCLLICKDTSRRIGCpRPN 120
XP_015781621  55 YEPTLSMSGG--RLAIACKVCGAMIDVTEKREQHVVKCEQCNEATPIKPAPAGKKYVRCPCNCLLVCKAPAQRIACpRRN 132
Q2LZQ8        62 YQQS-SNTGG--VPMVTCRVCQHMIDITTKREQHVVKCTHCNEATPIRNAPPGKKYVRCPCNCLLICKSSSQRIACpRPN 138 Drosophila pseu...
2_pfamImport  43 YQ---AALHG-NAPMVTCRVCQAMIDVSGKRDQHVVKCSNCNEATPIRNPPPGKKYVRCPCNCLLICKSSSQRIACpRPN 118
XP_011145409  50 YQ---SATQG-GMPMVTCRVCQAMIDISGKRDQHVVKCSQCNEATPIRNAPPGKKYVRCPCNCLLICKSSSQRIACpRPN 125
Q16QP8        46 YQ---QEQQS--SVIVTCRVCQALIDISWKKEQHVVKCSQCHEATPIRNAPPGKKYVRCPCNCLLICKSSSQRVACpRPN 120 yellow fever mo...
Q66I51        53 YSPLGSPESS-SAPVISCRVCQSLISVEGKIHQHVVKCGVCNEATPIKNAPAGKKYVRCPCNCLLICKVTSQRIACpRPY 131 zebrafish
4_pfamImport  67 YSPQGSPDSGsSAPVISCRVCQSAIPVEGKAHQHVVKCDICNEATPIKNAPVGKKYVRCPCNCLLICKVTSQRIACpRPY 146
CAG02185      52 YSPQGSPDSG-SPPVVNCRVCQSAISVEGKMHQHVVKCGICSEATPIKNPPVGKKYVRCPCNCLLICKVTSQRIACaRPY 130 spotted green p...
XP_316310     43 YQ---QEQQN--SIIVTCRVCQALIDISWKKEQHVVKCLQCNEATPIRNAPAGKKYVRCPCNCLLICKSSSQRVACpRPN 117 Anopheles gambi...
XP_006013160 121 CRRIINL-----------------------------GPVllipEEQPAQPALpvQPEGTRVVCGHCGNTFLWMELRfNTL 171
XP_015781621 133 CLRIINLnlenrsnagnqipsalneggermdnvtssGPL----------------PEMCRVTCGHCYESFLFNTLS-NSL 195
Q2LZQ8       139 CKRIINL-----------------------------APS-------PVTPPVptMPGMCRVICGHCSDTFLFNTYH-NAL 181 Drosophila pseu...
2_pfamImport 119 CKRIINL-----------------------------SPS-------PVTPPLpsMPGMCKVTCVHCRDTFLFNTLR-NAL 161
XP_011145409 126 CKRIINL-----------------------------APS-------PITPPVlsMPGMCRVGCAHCHDTFLFNTLN-NAL 168
Q16QP8       121 CKRIINL-----------------------------APS-------PVTPPLlsMPGMCRVTCGHCHDTFLFDTLK-NNL 163 yellow fever mo...
Q66I51       132 CKRVINL-----------------------------GPV----NPGAGSPNP--QPTGARVSCGHCAKTFLWTEFTdRTL 176 zebrafish
4_pfamImport 147 CKRVINL-----------------------------GPV----HIGRESPEPqhQPVGVRIICGHCANTFLWTEFSdRTL 193
CAG02185     131 CKRIINL-----------------------------GPV----HISRESSEPqhQPVGIRVLCGHCSNVFLWKEISdRTL 177 spotted green p...
XP_316310    118 CKRIINL-----------------------------APS-------PVTPPLlpMPGMCRVTCGHCHDTFLFDTLK-NNL 160 Anopheles gambi...
XP_006013160 172 AKCPHCKKISSVGSALPRRRCCAYITIGMICVFIGVGLT---------------------------VGTQDFARRYHATY 224
XP_015781621 196 ARCPHCRKLSSVGPEFARFKGLVYLVISIIFFAIALGVT---------------------------LGTLKYFSDFKSLI 248
Q2LZQ8       182 ARCPHCRKVSSVGSRFANSRGVMFAIVALLFLVAGIAVT---------------------------IGTISYASAHGGMY 234 Drosophila pseu...
2_pfamImport 162 ARCPHCRKVSSVGPQFAKNRGKIFLVIALILFAIGVSIT---------------------------LGTYKYATINGGYI 214
XP_011145409 169 ARCPHCRKISSVGPDFARGRGIVFIIVGIITLIIAIAVT---------------------------LGTYRYVKTNGGIY 221
Q16QP8       164 ARCPHCRKVSSVGADFCRKRRNLLFLGGLIFLAIGMGVT---------------------------YGTLAYAKDHSGMY 216 yellow fever mo...
Q66I51       177 ARCPHCRKVSSIGQRYPRKRSLICFLLCLIFVITTAGLI---------------------------AGTWLKAQKYKGIY 229 zebrafish
4_pfamImport 194 ARCPHCRKVSSIGRRYPRRRSLLCFLLFVVLATSTAGL----------------------------VGTWTPARHSKGIY 245
CAG02185     178 ARCPHCRKVSSIGRGYPRKRSLLCFLLFVVLVASTAGLMvsvcvylslctfkgrmilqishdfyhqVGTWKPAQNSKGIY 257 spotted green p...
XP_316310    161 ARCPHCRKVSSVGADFCRKRRNLHFLGGIIFLAIGIGVT---------------------------FATYTYVRDYGGIF 213 Anopheles gambi...
XP_006013160 225 VSWAFAYLLGLICLVRACYWGAIKVS 250
XP_015781621 249 VLYIILFIADVAIIFRSLFYLTMKVS 274
Q2LZQ8       235 ILYVALFVIAVSMLARSAYYFRLKVS 260 Drosophila pseudoobscura
2_pfamImport 215 FAYIGAFLVGVIMLTRSIYYYTMKVS 240
XP_011145409 222 VAYVGAFLLALLCLGRSIYYCTMKIS 247
Q16QP8       217 IAYISLFLVALLLFGKTIYYCTLKVS 242 yellow fever mosquito
Q66I51       230 ASWVFFIVLVLVTLVRALHWACMKIS 255 zebrafish
4_pfamImport 246 VSWVLLILLALFTMARSIYWRCLKIS 271
CAG02185     258 VSWVLLILLTLLTVARTIYWICLKIS 283 spotted green pufferfish
XP_316310    214 VAYISLYLISVLLFAKALYYCSLKIS 239 Anopheles gambiae str. PEST
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