5K25,5K23


Conserved Protein Domain Family
PTP-IVa2

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cd18536: PTP-IVa2 
Click on image for an interactive view with Cn3D
protein tyrosine phosphatase type IVA 2
Protein tyrosine phosphatase type IVA 2 (PTP-IVa2), also known as protein-tyrosine phosphatase of regenerating liver 2 (PRL-2), stimulates progression from G1 into S phase during mitosis and promotes tumors. It regulates tumor cell migration and invasion through an ERK-dependent signaling pathway. Its overexpression correlates with breast tumor formation and progression. PRL-2 is a member of the PTP-IVa/PRL family of small, prenylated phosphatases that are the most oncogenic of all PTPs. PRLs associate with magnesium transporters of the cyclin M (CNNM) family, which results in increased intracellular magnesium levels that promote oncogenic transformation.
Statistics
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PSSM-Id: 350512
Aligned: 5 rows
Threshold Bit Score: 330.424
Created: 29-Nov-2017
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 2 residue positions
Conserved feature residue pattern:C RClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic cysteine initiates a nucleophilic attack on the phosphate group of the substrate, forming a transient phosphoenzyme intermediate and releasing the substrate dephosphorylated; the transition state is stabilized by the arginine present in the catalytic pocket

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
5K25_A        24 MNRPAPVEISYenMRFLITHNPTNaTLNKFTEELKKyGVTTLVRVCDATYDkAPVEKeGIHVLDWPFDDGAPPPNQIVDD 103 human
5K23_A        23 MNRPAPVEISYenMRFLITHNPTNaTLNKFTEELKKyGVTTLVRVCDATYDkAPVEKeGIHVLDWPFDDGAPPPNQIVDD 102 human
XP_006019417   1 MNRPAPVEITYenMRFLITHNPTNaTLNKFTEELKKyGVTTLVRVCDATYDqAPVEKeGIQVLDWPFDDGAPPPNQIVDD 80  Chinese alligator
NP_001080240   1 MNRPAPVEISHecMRFLITHNPTNaTLNKFTEELKKyGVTTLVRVCDATYDkAPVEKeGIQVLDWPFDDGAPPPTQIVDD 80  African clawed ...
NP_001257469   7 MNRPAAVEISYdcMRFLITHNPTNsTLNKFTEELKKfEVNTLVRVCEATYDtALVQKeGIQVFDWPFDDGASPPTRIVDD 86  zebrafish
Feature 1                            #     #                                                
5K25_A       104 WLNLLKTKFReepgCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRL 178 human
5K23_A       103 WLNLLKTKFReepgCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRL 177 human
XP_006019417  81 WLNLLKTKFReepgCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRL 155 Chinese alligator
NP_001080240  81 WLNLLKTKFReeagCCIAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRL 155 African clawed frog
NP_001257469  87 WLNLLKTKFReepgCCIAVHCVAGLGRAPVLVALALLECGMKYEEAVMYIRQKRRGAFNAKQLMYLEKYRPKMRL 161 zebrafish

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