Conserved Protein Domain Family
NDFIP2
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cd22306: NDFIP2 
NEDD4 family-interacting protein 2
The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP2 may play a role in protein trafficking.
Links
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Statistics
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PSSM-Id: 412070
Aligned: 6 rows
Threshold Bit Score: 342.255
Created: 8-Jul-2020
Updated: 30-Sep-2020
Structure
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Aligned Rows:
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PPxY motif
Feature 1: PPxY motif, 6 residue positions
Conserved feature residue pattern:P P Y P P YClick to see conserved feature residue pattern help
Evidence:
  • Comment:PPxY motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      ## #                      ## #    
NP_001025991   7 ASRYQVLHNEDDPPEssvaeqpststet---tqtpqtaalseaDTSPPPYCSIDVEaaat--sethNEFYPVPPPYSVAT 81  Gallus gallus
Q9NV92       102 TGRYQVLLNEEDNSEssaieqpptsnpapqivqaassapaletDSSPPPYSSITVEvpttsdtevyGEFYPVPPPYSVAT 181 Homo sapiens
NP_998512      5 ASRYQVLHNEDDSSEgaasaepststqav-galegisnlavdtEAPPPPYASVALGataap-estfAGDFPVPPPYSIAT 82  Danio rerio
XP_007900758  13 CSRYQVLHNEDDPPQssttleqnlps-------essqppppeiDAPPPPYCSLTGAaagatgidfqSDLMPVPPPYSVAT 85  Callorhinchus m...
NP_001087394   9 ANRYQVLQNEDDSSEaptveqpststq----psqaaqntssvsDVSPPPYSSIVAGtttd--aetsSDFYPVPPPYSVAT 82  Xenopus laevis
XP_005991326   7 VSRYQVLHNEDDPAEpsveepstsaqp----vqtsqavsppevNAPPPPYSSVVAGataaaetevqNEFYPVPPPYSVAT 82  Latimeria chalu...

Feature 1                                                                                        
NP_001025991  82 SLPTYDEAEKAKAAAMAAaaaev--------------------aqreEEYPPRDDFSDADQLRVGNDGIFMLAFFMAFIF 141 Gallus gallus
Q9NV92       182 SLPTYDEAEKAKAAAMAAaaaets------------------qriqeEECPPRDDFSDADQLRVGNDGIFMLAFFMAFIF 243 Homo sapiens
NP_998512     83 SLPTYDEAEKAKAAAMAAsavev--------------------iprdEDFPVRDDFSDADQLRVGNDGIFMLAFFMAFLF 142 Danio rerio
XP_007900758  86 SLPTYDEAEKAKAAAVAAgiada--------------------tqreEEFPPRDDFNDADQLRVGNDGIFMLAFFMAFLF 145 Callorhinchus m...
NP_001087394  83 TLPTYDEAEKAKAAAMAAvaae---------------------aqreEEYPPRDDFSDADQLRVGNDGIFMLAFFMAFIF 141 Xenopus laevis
XP_005991326  83 SLPTYDEAEKAKAAAMAVaaaestqrhgqfresrslfdeiflsppeeEEYPPRDDFSDADQLRVGNDGIFMLAFFMAFIF 162 Latimeria chalu...

Feature 1                                                                                        
NP_001025991 142 NWIGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSES 221 Gallus gallus
Q9NV92       244 NWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSES 323 Homo sapiens
NP_998512    143 NWIGFCLSFCLTNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSES 222 Danio rerio
XP_007900758 146 NWIGFCLSFCLTNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFINYLKVRNMSEN 225 Callorhinchus m...
NP_001087394 142 NWIGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSES 221 Xenopus laevis
XP_005991326 163 NWIGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSES 242 Latimeria chalu...

Feature 1                     
NP_001025991 222 MAAAHRTRFFFLY 234 Gallus gallus
Q9NV92       324 MAAAHRTRYFFLL 336 Homo sapiens
NP_998512    223 MVSSLRTRFFLLY 235 Danio rerio
XP_007900758 226 MAAAHRTRLLFLY 238 Callorhinchus milii
NP_001087394 222 MAAAHRTRFFFLY 234 Xenopus laevis
XP_005991326 243 MAAAHRTRFFFLY 255 Latimeria chalumnae

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