2E0T,4HRF,5GTJ


Conserved Protein Domain Family
DUSP26
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cd14578: DUSP26 
dual specificity protein phosphatase 26
Dual specificity protein phosphatase 26 (DUSP26), also called mitogen-activated protein kinase (MAPK) phosphatase 8 (MKP-8) or low-molecular-mass dual-specificity phosphatase 4 (LDP-4), functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). It deactivates its MAPK substrates by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. DUSP26 is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. It is a brain phosphatase highly overexpressed in neuroblastoma and has also been identified as a p53 phosphatase, dephosphorylating phospho-Ser20 and phospho-Ser37 in the p53 transactivation domain.
Links
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Statistics
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PSSM-Id: 350426
Aligned: 8 rows
Threshold Bit Score: 284.424
Created: 7-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x C x x x x x R x x x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:5GTJ: Human DUSP26 binds a phosphate ion in the active site; contacts at 4A
  • Comment:primarily based on the structure of human VHR/DUSP3 with bound bisphosphorylated MAP kinase peptide
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #                                              #                     
2E0T_A         2 ADEVWPGLYLGDQdmaNNRRELRRLgiTHVLNAShsRWRGTPEAYeglGIRYLGVEAHDSPaFDMSIHFQTAADFIHRAL 81  human
4HRF_A         3 ADEVWPGLYLGDQdmaNNRRELRRLgiTHVLNAShsRWRGTPEAYeglGIRYLGVEAHDSPaFDMSIHFQTAADFIHRAL 82  human
5GTJ_A        24 ADEVWPGLYLGDQdmaNNRRELRRLgiTHVLNAShsRWRGTPEAYeglGIRYLGVEAHDSPaFDMSIHFQTAADFIHRAL 103 human
XP_424530     48 ADEVWPGLYLGDQdiaANRRELAHLriTHILNAShsKWRGGAEYYegtGIRYLGIEAHDSPsFDMSPYFYPAADFIHQAL 127 chicken
XP_002933015  44 ADEVWPNLYLGDQdiaADKGELLRLniTHILNAChsRFRGGEDYYkgmNISYMGIEAHDSEiFDMSIHFDPAADFIHKAL 123 western clawed ...
XP_699429     48 ADEVWPRLYIGDQeiaSNRKELVKLgiTHILNCAqsKWRGGAEYYagmNITYHGIEAHDSPsFDMSVNFYPAAEFIHRAL 127 zebrafish
XP_005988285  47 ADEVWPGLYLGDQdiaANRRELTKLgiTHILNAChsKWRGGAEYYegmNITYFGVEAHDSPtFDMSPHFYPAADFIHQAL 126 coelacanth
XP_007907419  42 VDQVWPRLYIGDQdvaSDRRELVKLglTHVLNAVhsKWRGEAELYkdlNITYCGIEAQDCPlFDMSVHFYPAADFIHRAL 121 elephant shark

Feature 1                  #######                              ####             
2E0T_A        82 sqpggKILVHCAVGVSRSATLVLAYLMLYHhltlVEAIKKVKDHRGIIPNRgFLRQLLALDRRL 145 human
4HRF_A        83 sqpggKILVHSAVGVSRSATLVLAYLMLYHhltlVEAIKKVKDHRGIIPNRgFLRQLLALDRRL 146 human
5GTJ_A       104 sqpggKILVHSAVGVSRSATLVLAYLMLYHhltlVEAIKKVKDHRGIIPNRgFLRQLLALDRRL 167 human
XP_424530    128 ne--gRILVHCAVGVSRSATLVLAYLMIRHhmplVEAIKTVKDHRGIIPNRgFLRQLVALDNAL 189 chicken
XP_002933015 124 rg-rgKILVHCAVGVSRSATLVLAYLMIHHnmtlVEAITTVKERRGIIPNRgFLRQLLNLDKSL 186 western clawed frog
XP_699429    128 sa-ggTVLVHCAVGVSRSATLVLAYLMIRQnmtlLEAIRTVKDHRGVTPNRgFLRQLSGLDSVL 190 zebrafish
XP_005988285 127 qetgrKILVHCAVGVSRSATLVLAYLMIHHhmtlVEAIKTVKDHRGIIPNRgFLRQLVNLDNTL 190 coelacanth
XP_007907419 122 rdsggKVLVHCAVGISRSSTLVLAYLMIHQrmtlESAIKAVMQHRGIVPNRgFLQQLLTLDKSL 185 elephant shark

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