Conserved Protein Domain Family
GT29_ST6GAL2
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cd23986: GT29_ST6GAL2 
beta-galactoside alpha-2,6-sialyltransferase 2
ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467714
Aligned: 6 rows
Threshold Bit Score: 575.633
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 ###                    
Q96JF0       245 GLSRAQLLCQLRSRaRVRTLDGTEAPFSaLGWRRLVPAVPLsql--hprGLRSCAVVMSAGAILnSSLGEEIDSHDAVLR 322 human
XP_005998062 224 KLSAEELLCELKRKiQLKTIDGKEPPFSaLGWEKYVPRIPLnk----lnGYRSCAVVTSAGAILdSSLGKEIDSHEAVLR 299 coelacanth
Q701R1       236 KLNPQELLCVLKDRaQVKTLDGKDAPFSsLGWEKYFPKIALnkl--yphGFSTCAVVSSAGAILnSSLGAEIDSHDAVLR 313 tropical clawed...
NP_001279552 238 KLSGDELLCELKKRvRLRTLDGNETPFSlLGWKKYVPKIPLskiklklrVFRKCAVVASAGAILnSSLGDEIDSHDAVMR 317 elephant shark
Q701R2       238 KQSRQQVLCELKKReKIRTLDGAEMPFSkLGWQKIVPALPLsqi--hrpGLKTCAVVTSAGAMLhSGLGKEIDSHDAVLR 315 zebrafish
Q701R0       246 KLTGDQLFCELKERvDVKTIDGKEAPFStLGWEKHVPQIPLgkl--ythGFGSCAVVMSAGAILnSSLGDEIDSHDAVLR 323 chicken

Feature 1        ##                    #                                                         
Q96JF0       323 FNsAPTRGYEKDVGNKTTIRIINSQILTNPshhfidssLYKDVILVAWDPAPYsanLNLWYKKPDYNLFTPYIQHRQRNP 402 human
XP_005998062 300 FNsAPTQGYEKDVGNKTTIRIVNSQILTNPsqhfmdnpLYKDGILVAWDPAPYsvnLKKWYNKPDYDLFTPYVQYRLKYP 379 coelacanth
Q701R1       314 FNsAPTRNYEKDVGNKTTLRIINSQILTNPnhhftdssLYKDVTLIAWDPSPYyadLHMWYHKPDYNLFPPYEKHRKRNP 393 tropical clawed...
NP_001279552 318 FNaAPTKLYEQDVGSKTTIRILNSQILANSkhnfinnaLYKNIILVVWDPAPYsinLIKWYKKPDYNLFTPYLRYRRRNP 397 elephant shark
Q701R2       316 FNtAPTVGYERDVGNKTTIRIINSQILANPmhrfnrssLYKNVTLVAWDPAPYtlnLHQWYSNPDYNLFTPYMEYRMRFP 395 zebrafish
Q701R0       324 FNsAPTRGYEKDVGNKTTMRIINSQILTNPnhhfvdssLYKDVILVAWDPAPYs-aNLNWYKKPDYNLFTPYVQHRKKNP 402 chicken

Feature 1                                        ###                 ##        ###               
Q96JF0       403 nQPFYILHPKFIWQLWDIIQENtkekiQPNPPSSGFIGILIMMSmCREVHVYEYIPSvRQTELCHYHELYYDAACTLGAY 482 human
XP_005998062 380 gQPFYILHPRFIWQLWDIIQENtqekiQPNPPSSGFIGILLMMSmCKEVHVYEFIPSvRQTDLCHYYERYYDAACTLGAY 459 coelacanth
Q701R1       394 dQPFYILHPKFTWELWKIIQENsnekiQPNPPSSGFIGILIMMSmCRTVHVYEYIPSyRQTDLCHYHEQYYDAACTLGAY 473 tropical clawed...
NP_001279552 398 aQPFYILHPRFLWQLWDIIQENtqekiQPNPPSSGFIGIVIMMAlCDSINIYEYIPSiRQTDLCHYHERYYDSACTLGAY 477 elephant shark
Q701R2       396 sQPFYILHPKYIWQLWDVIQANnleniQPNPPSSGFIGILLMMSlCEEVHVYEYIPSlRQTDLCHYHERYYDAACTLGAY 475 zebrafish
Q701R0       403 nQPFYILHPKFIWQLWDIIQENtkekiQPNPPSSGFIGILIMMSmCNEVHVYEYIPSvRQTDLCHYHELYYDAACTLGAY 482 chicken

Feature 1        #                               
Q96JF0       483 HPLLYEKLLVQRLNmGTQGDLHRKGKVVLPGF 514 human
XP_005998062 460 HPVLYEKLLIQRMNkGKEEDLYRKGKVVLPGF 491 coelacanth
Q701R1       474 HPLLYEKMLIQRINqGTEDNLLRKGKVILPGF 505 tropical clawed frog
NP_001279552 478 HPLLYEKLLVQRMNkGTEADLYSKGRVSLPGF 509 elephant shark
Q701R2       476 HPLLYEKMLIQRMNiGSEDELKRKGKVTLPGF 507 zebrafish
Q701R0       483 HPLLYEKLLVQRMNkGLQDDLYRKGKVILPGF 514 chicken

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