Conserved Protein Domain Family
SLC5sbd_NIS
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cd11503: SLC5sbd_NIS 
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain
NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Links
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Statistics
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PSSM-Id: 271393
Aligned: 4 rows
Threshold Bit Score: 876.095
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q92911        15 WDYGVFALMLLVSTGIGLWVGLa-rGGQRSAEDFFTGGRrLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLwMCLG 93  human
Q63008        15 WDYGVFATMLLVSTGIGLWVGLa-rGGQRSADDFFTGGRqLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLwMCAG 93  Norway rat
NP_001082860  14 VDYAVFAAMLGVSVGIGLFQSLrktPGRSKVDSFFTGGRgFSAVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLyMCLG 93  zebrafish
NP_001086891  56 WDYGVFAVMLLMSTGIGLFYAFs-hGGQKTSDDFFTGGRsMSAVPVGLSLSASFMSAVQVLGVPAESYRYGVKFLqMCIG 134 African clawed ...

Feature 1                                                                                        
Q92911        94 QLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGI 173 human
Q63008        94 QLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGI 173 Norway rat
NP_001082860  94 QGLNSLMTAVLFVPVFYRLKITSSSQYLGMRFGRGMQLLGSLQFIVATLLYTGIVIFAPAVILNQATGLNMWASLFSTGL 173 zebrafish
NP_001086891 135 QILNSLMTAYIFMPIFYRLGITSTYEYLEMRFSRSVRLYGTIQFLLGTMFYTGIVIYAPALILNQVTGLDIWASLFSTGA 214 African clawed ...

Feature 1                                                           #                            
Q92911       174 ICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTL 253 human
Q63008       174 ICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTL 253 Norway rat
NP_001082860 174 ICTFYTTVGGMKAVIWTDVFQIVVMLSGFIAVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWSFTVGGTM 253 zebrafish
NP_001086891 215 ICTFYTTVGGMKAVIWTDVFQVLVMLSGFFAVAIRGIHLVGGFSDAIEIAGNYSRINFGDFDPDPRRRYTFWTFVMGSTF 294 African clawed ...

Feature 1                                                                                        
Q92911       254 VWLSMYGVNQAQVQRYVACRTEkqAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIF 333 human
Q63008       254 VWLSMYGVNQAQVQRYVACHTEgkAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIF 333 Norway rat
NP_001082860 254 VWLSMYGANQAQVQRYISCRTEkqAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCDPLKIGRISAPDQYMPYLVLDIF 333 zebrafish
NP_001086891 295 LWLSMYGVNQAQVQRYVACKTEneAKLAILVNQVALCVIVSSAVTCGIVMFVYYLNCDPLLAGYVSAPDQYMPYFVLEIF 374 African clawed ...

Feature 1                                                                                        
Q92911       334 edlPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLapRKLVIISKGLSLIYGSACLTVAALSSLLGGGVL 413 human
Q63008       334 edlPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLapRKLVFISKGLSFIYGSACLTVAALSSLLGGGVL 413 Norway rat
NP_001082860 334 rnhPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPWLITIsqRKQLMLSRALSLFYGLGCITMAALSSLLDWGVL 413 zebrafish
NP_001086891 375 dqyPGIPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPKYPNIptKKLTFISKGLSLIYGCSCITVAALSSLLGGGVL 454 African clawed ...

Feature 1                                                                                        
Q92911       414 QGSFTVMGVISGPLLGAFILGMFLPaCNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSvnasgl 493 human
Q63008       414 QGSFTVMGVISGPLLGAFTLGMLLPaCNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNDSvllgp- 492 Norway rat
NP_001082860 414 QGSFTVMGVVNGPLLGAFALGMFVPaTNKPGVFSGVAVGFCLSLWLAVGSTIYPPSPQIMGVLPTSAGQCLTTNatlnt- 492 zebrafish
NP_001086891 455 QGSFTVMGVISGPLLGAFMLGMFFVsCNTIGVFAGLLVGLVLSLWVAVGGTIYPPSAEMMGVLPTYAEHCPLFNssk--- 531 African clawed ...

Feature 1                                                                     
Q92911       494 ldpallpaNDSsrapssgmdasRPALADSFYAISYLYYGALGTLTTVLCGALISCLtGPTK 554 human
Q63008       493 ----pgatNASngipssgmdtgRPALADTFYAISYLYYGALGTLTTMLCGALISYLtGPTK 549 Norway rat
NP_001082860 493 ----tasvLASsvpldysfqniYSISYLYFGALSTSAVVLVGVVVSYITGPTKKDSiSPGL 549 zebrafish
NP_001086891 532 -----giiYGPapvqnithtmeRPALAEDLYALSYLYYGVVGTFSTIIIGVIVSKFtGPTK 587 African clawed frog

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