Conserved Protein Domain Family
TM4SF2_6_like_LEL

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cd03161: TM4SF2_6_like_LEL 
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.
Statistics
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PSSM-Id: 239414
Aligned: 14 rows
Threshold Bit Score: 135.952
Created: 7-Nov-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:dimeric assembly observed in the crystal is predicted to resemble quaternary structure of intact CD81 at the cell surface

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #    #   # ##  #                 #  ##  ##                                     
AAH44697  110 FVFRHEIKDTFLRTYTEAIQNYng----nDERSNAVDDVQRNLRCCGVQYYTNWTSSLYwh------------dhGFPPS 173 African clawed frog
BAD93113  152 FVFRHEIKNSFKNNYEKALKQYns---tgDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYys------------ekGFPKS 216 human
AAH81682  110 FVFRHEIKGTFLRTYNEAVQNYna----qDERSIAVDNVQRSLRCCGVLNYTSWFSSIYfp------------vnGIPPS 173 zebrafish
XP_620512 102 VLLHREIKNRFLKIYTNAVRNYns----nDRKSQAVDQVQYSLMCCGVKNYTDWNDNPYfl------------nhGIPPS 165 house mouse
CAG02436   99 LFYREDIAGGFRSGLQRAVAGYte----dEGRADALDSLQRALDCCGAEGWRDWLNSDWavqhttfqtsengssvSLPDS 174 Tetraodon nigrovir...
XP_420247 160 FVFRHEIKTNFESNLNLALKNYng---taDHHSEAVDTIQRTLHCCGVQNYSDWEKTEYft------------qkGIPQS 224 chicken
CAF95792  143 VSVCVQIKGTFFTTYNEAVMRYdg----lDDRSLAVDGVQRSLRCCGVHNYTSWFNSVYfp------------vsGFPAS 206 Tetraodon nigrovir...
CAG09847  137 FVFRHEIKAKLKVAFENDVMSYnssdsssSSTSSVVDTIQRSLHCCGVKNFTDWGETLYfk------------ekGIPTS 204 Tetraodon nigrovir...
NP_999939 112 FIFRHEIKAVLKGAYQKAESNYm------GKDDEDLDRIQRTLQCCGEENYTSWANTTYfe------------keGIPKS 173 zebrafish
XP_426904 189 LLYRQDIARGFREGLRQALSAYge----dEGKADALDALQRTLGCCGVESYRDWLASPWalq----------qnaSVPLS 254 chicken
Feature 1                                                  
AAH44697  174 CCANn--sDCNPEDLrnmti---nftkVNQRGCYELVTSFMETNM 213 African clawed frog
BAD93113  217 CCKLe---DCTPQRDad---------kVNNEGCFIKVMTIIESEM 249 human
AAH81682  174 CCANi--sDCNASDLrnati---aptkVYQQGCYELVTTFIETNM 213 zebrafish
XP_620512 166 CCKDe--aDCSLQDRqnlta---vatkVNQRGCYVLMVGFLEANM 205 house mouse
CAG02436  175 CCVRr--kGCKNRPLmsddnegvaaagIHPHGCFRKVFSLVNDNV 217 Tetraodon nigroviridis
XP_420247 225 CCKSq--dDCSVEDLrdpsk---akqkVFVDGCFFLVTSAMESKM 264 chicken
CAF95792  207 CCVSf--sDCSYADLknstl---aarkVHKQGCYQLVTSFIERNM 246 Tetraodon nigroviridis
CAG09847  205 CCKDt--tKCSPETLkdldk---aateVYATGCFTLVTNVMEANL 244 Tetraodon nigroviridis
NP_999939 174 CCNVtasvNCTSAELkdlkk---adsvVYHQGCFSLMSTTMEANL 215 zebrafish
XP_426904 255 CCRAr--rGCSLSSAga--------rgLHPEGCFGKVSALVSSNM 289 chicken

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