Conserved Protein Domain Family
Tsg

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pfam04668: Tsg 
Twisted gastrulation (Tsg) protein conserved region
Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilization; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling.
Statistics
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PSSM-Id: 461385
Aligned: 31 rows
Threshold Bit Score: 112.384
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_794111     85 DIASYSTINDLrmeSDWTDTLFNALTQVDKPHPd--sHWTvervtpqeegvnlpglvpatpsegstsdvspssKTAtTAI 162
XP_006012404  83 HPTSRSSVEDL---LVPIPSLFRALTTISDNDPp--mGWSvvsipvteelrhqhh---rhhimlgshkvaellPGSsENS 154
NP_001015756 101 HSARRSSLEEL---PVSVPSLFRAVSSMQEGESa--lGWTahnlpileelaqsth---mdhillgahsvvtasPLTnISG 172
3_pfamImport   1 PPIMTSTVAIF---DKPEPRLFVALTESSVPAL----RCSivrfpvsqelaahgsr--elyhrrhhgkppevaQDIeHTA 71 
ELV12750      11 PPTSKSTVEEL---HEPIPSLFRALTEGDTQL-----NWNivsfpvaeelshhenl--vsfletvnqphhqnvSVPsNNV 80 
NP_571872     87 PATSKSTVEEL---YRPIPSLFRALTEGDAPI-----NMMvvsfpvaeelshhen---lvsfletldsqsqniSLPtSSA 155
Q98SR9        85 PATGRSTVEDL---FQPIPSLFRALTEGDAPT-----HTLvltlplaeelqyqhnl-hnyletlhntqhnnttSVPeNSI 155 zebrafish
EEN49924      83 AASSKSSISDL---TDPIPSLFKALT---DPSQdthlKWTimripadgdtpaisa---hhffhlidkslpdlpVLTpPHH 153
EKC19725     429 DLQDGSTIEDL---HDPIPELFNVLTEQEDIEK----RWTtfilpvhfdvla----------hksnhgildlsKDKrQEV 491
XP_003975395  88 PATSRSTVEEL---HRPIPSLFRALTEGESPI-----NMMvvsfpiaeelshhen---lvsflesldnphqnvSVPgNSI 156 torafugu
XP_794111    163 S-------V-----NqtivpidiCTVAYIKICLGLEKCVDACHHMGAAKYRWFHT-GCCECIGSSCLSYGKKKALCSECP 229
XP_006012404 155 Ta--------------------vCTVLYFHSCMSMNRCKQSCESLGASRYRWFHN-ACCECVGPDCHAYGSKEAACQNCN 213
NP_001015756 173 S----------------------CTVLYFNPCMSMRRCHQSCESVGSPRYRWFHN-GCCQCVGPDCHGYGSKEPLCLQCQ 229
3_pfamImport  72 Tkd------------------piCVVMYFDECMSLNDCRMNCESTGSTSYRWFHN-GCCECVGPDCLNHGHMEAKCSNCL 132
ELV12750      81 Hapyas------------dkehmCTVVYFDDCMSIHQCKISCESMGASKYRWFHN-ACCECIGPECIDYGSKTVKCMNCM 147
NP_571872    156 Qdd------------------alCTVVYFDDCVSIRQCKQYCESMGGSKYRWFHN-ACCECIGPECLDYGSKTVKCMNCL 216
Q98SR9       156 Hssyht-------------qdkqCTVVYFDECVSIRQCKQYCESMGGSKYRWFHN-ACCQCIGPECVDYGSKSVRCLNCL 221 zebrafish
EEN49924     154 Ngtq-----------------dlCTVVFFDDCMSDDKCKMSCESMGASRYRWFHN-GCCQCIGPDCKNYGLNKVKCSNCM 215
EKC19725     492 TkdtygadL-----N--------CTVAFMSQCYSLRKCKESCKSMGAARYRWFHEqGCCQCIGDTCISYGLNSPKCLQCP 558
XP_003975395 157 H-------TsydaqEn------mCTVVYFDECVSIRQCKMYCESMGGSKYRWFHN-ACCQCIGPECVDYGSKAVKCMNCL 222 torafugu
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