3FHN,6WC3


Conserved Protein Domain Family
RINT1_TIP1

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pfam04437: RINT1_TIP1 
RINT-1 / TIP-1 family
This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control, as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for Golgi transport.
Statistics
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PSSM-Id: 461309
Aligned: 58 rows
Threshold Bit Score: 275.318
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FHN_A              244 WNFKSLANNFNVRFTYHFHAt---SSSSKIETYFQFLNDYLAENLYKCINIFHD--DCNGLTK--PVihEQFINYVLQPI 316 baker's ...
XP_015787512        225 LPLQLMVKPLRKRFTYHFMTnvrtNQLSKPEWYLTQIMNWIKDHENFLSEHVTVlfKDQETEFasLK--IQFTCALLELA 302
EDO38509            241 LPLDWLLKPLRKRFKFHFYGkkqtNNLEKPEWYFTQILNWIKSHGDFLQHTVQPvlDKAELSFidAK--LEFIRGLLAVT 318
ELK01327            290 LPIQIMLTPLQKRFRYHFRGnrqtNVISKPEWYLAQVLLWIGNHTEFLDEKIQPilDKVGSSi-nAR--LEFSRGLMMLV 366
XP_015207675        211 LPIQIMLLPLSKRFRYHFTGnrqtNTPNKPEWYLTQVLMWMGNHSAFMEEKIQPilDRDGARi-nAR--VELCRGLLSLA 287
Q5RGZ9              285 LPIQIMLLPLSKRFRYHFTGnrqtNSLSKPEWYLTQILIWMGNNSNFMDEKVQPilDRAGGNv-nAR--VELCRGLLTLA 361 zebrafish
XP_003972690        284 LPIQIMLLPFRKRFRYHFCGnrqtSSLSKPEWYLTQVLLWMSNNSTFMEEKIQPilEG-AETHlsAR--VELCRGLLALV 360
XP_003455706        288 LPIQIMLLPLNKRFKYHFYGnrqtNSLSKPEWYLTQVLMWMGNNSTFMEETIQPilDRGGVTl-sAK--VELCRGLLSLV 364
WGS:AATM:SJAG_01166 196 L-MKCICRPFNIQFKYHFMTekktNTPSKPEWFYEFALKVFRSSLSFI-QLFQQimPEGMIAV------HEFMKVMQELM 267
Q9C0W8              200 LFMQVYITPYVNQFRYHFMSqkqtNVLSKPEWFFEFLLKVFRSNRSFYMLMRDIkfFPGVPPF------FTFINLLNNVA 273 Schizosa...
3FHN_A              317 RDKVRST----LfqndLK--TLIVLISQILATDKNLLN-SFHYH------GLGLVS-LISdEV--WEKWINYEVEXANRQ 380 baker's ...
XP_015787512        303 ADKLAKDltklS----ADdkLFSHAFDEVLLTQRELEDiNQDWLslfrenCNLLS--LFA-VEpyFTRLRNIERRRSMEY 375
EDO38509            319 TEKMIHSlpelL----ADeaVFSHFVDETLLFHKELHE-LYNYPltd---hsCLK--VLT-RKqcLGKWVELERKYAIEN 387
ELK01327            367 LEKLAADipclL----YDdnLFCHLVDEVLLFERELHS-VHGYPgtf---anCLH--ILS-EEtcFQRWLTVERKFALQK 435
XP_015207675        288 LEKLAADaprlL----FDdaLFCHLVDEVLQFERELRG-THAYPstl---pgALH--ILL-DDavFQKWLSVEKKLAVEK 356
Q5RGZ9              362 QEKLAHDaprlL----YDdaLFCHLVDEVLQFEKELRS-THSYPray---pgVLH--ILL-EEsvFQKWLSVERKMAVEK 430 zebrafish
XP_003972690        361 QEKVASDalrlL----YDdaLFCHLVEEVLQFEKELRS-KLSYPp----aLPGLLH-LLL-ENtvLQKWLTVEKKMAVEK 429
XP_003455706        365 QEKVASDasklL----YDdvLFCHLVEEVLQFEKELRS-NHSYPa----eLPGVLH-LLL-EDavLQKWLTMEKKMAVEK 433
WGS:AATM:SJAG_01166 268 KEKINLImd------lDV--HLAHLIRETLYYSTKLKQ-LYNFPq-----KDSLSLyLLK-QPmvYSRWLDIEAADVKMQ 332
Q9C0W8              274 KEKLTHIik------yDD--YLVHLVHETLQYSVRLEQ-HFHYT------QDPLIIfLFE-QNgtYDKWLGLETQLSLTK 337 Schizosa...
3FHN_A              381 FINITKNPE-D-----F-------------PKSSQNFVKLINKIYDYLEPFYDLDFdllvryKLXTCSLIFXNLTSSYLD 441 baker's ...
XP_015787512        376 IETIISSETaWsplvtSiddedededilkvPEIADNFILMLQSITDRFSHLSKISH------QYAFIVL-ELEMLADFHL 448
EDO38509            388 MESLLASENaWr---pKyedvecgademraPECAEGFITILTVMTDRYRHLPGLDE------QSRFLAV-QLDLLKDFIT 457
ELK01327            436 MDSTLSSEAaWi---sQykditd-vdemkvPDCAETFMTLLLVITDRYKNLPTASR------KLQFLEL-QKDLVDDFRI 504
XP_015207675        357 VDALLAAEGaWs---sQyrdiad-ldelkvPDCAETFMTLLLVITDRYRSLPSPRA------RLSFLAL-QKELVDDFRI 425
Q5RGZ9              431 VDAMLSAEGaWs---sQykditd-mdelkaPDCAETFMTLLLVITERYRSLPCQRA------QLSFLAL-QKELVDDFRI 499 zebrafish
XP_003972690        430 MDAMLSSEGaWs---cQykemcd-mdelraPDCAETFMMLLQVITERYRYLTCPSA------QLKFLGL-QKELLDDFRI 498
XP_003455706        434 MDAMLSAERaWs---sQykdisd-mddlkaPDCAETFMTLLQVITERYRTLPCPSA------QLKFLEL-QKELVDDFRI 502
WGS:AATM:SJAG_01166 333 LNAIESSKDaWe----LarddveelytavpIKSFVLYRNAMASLKSILEMIPCEEF------CRGFFHTLQLKPSIQFVD 402
Q9C0W8              338 LEDIKIASDaWe----LesdqsddfssavpTKMTVRFRDMIETTFSVLQNLPSLDY------QFNFWRSVQLKPMMQYVN 407 Schizosa...
3FHN_A              442 YI--------LTVDSL--Net-rTKEQEL-------YQTXAKLQH-VNFVYRKIKSLSSNFIFIQLTDIV---NSTESKk 499 baker's ...
XP_015787512        449 RLsq-----------------iyRSLDSEglnqwpfTQRFFSIINtLNYVILLLNNWKNLPVFQDMSEFSlk-------- 503
EDO38509            458 LLsl-----------------taEESASNp-----vDACFISVLNaTSYIGFLLEDWNDQTLFLQLHGYFssend----- 510
ELK01327            505 RLtq-----------------vmKEETRAs-----lGFRYCAILNaVNYISTVLADWADNVFFLQLQQAAle-------- 554
XP_015207675        426 RLtq-----------------vmKEESRCp-----lGPRYCAILNaTNYVSAVLADWADNVFFLQLQQAAvd-------- 475
Q5RGZ9              500 RLtq-----------------vmKEESRQp-----lSSRYSAILNaANYISTVLSDWGDNVFFLQLQQAAvs-------- 549 zebrafish
XP_003972690        499 RLtq-----------------vmKEDSRYp-----lSARYCAILNaVNYISTILRDWGDNVFFLQLQQAA---VSLNDEv 553
XP_003455706        503 RLtq-----------------vmKEESRCp-----lGVRYCAILNaVNYISTILGDWGDDVFFLQLQQTA---VSLGEEa 557
WGS:AATM:SJAG_01166 403 WLesyyqn-hegstTLipGgahvTSEQSFs-----eVRRMCKLYGaFKLLLDWHLDLEDEEVYI-LSQETnleKPVDKQv 475
Q9C0W8              408 WLeafyesheSSSSIHlpGslqtDKSKFDia----eVERMCKLYSnFKLLMDWLDDIEDEDVYIRIGHKMgseNYA---- 479 Schizosa...
3FHN_A              500 y---nS---------------------LFQNVENDYEKAXSTdXQNSIVHRIQKLLKETLRNYFkiST--WSTLEX--SV 551 baker's ...
XP_015787512        504 -------------------------dsIFEDSLSLYNHMVNE-MKKRIVDSLMKLIMEKIKAY---ASlrWHCFTL--LD 552
EDO38509            511 ----------------------sgdcgVFDEPLKSLCELQKY-MSGLIVEDVVKGFRAKCKAY---RKerWHSLPS--PK 562
ELK01327            555 ----vFaenntlskle-lgqlasmessVFDNMINLLERLKHD-MLTRQVDHVFREVKDAAKLY---GKerWLSLPS--QS 623
XP_015207675        476 ----mGeevlgnlgvtetgrlaslegsVFEGLLGLLDRLRGD-MLGRLLDAVLRDVKDKAQPY---CRekWLSLPS--QA 545
Q5RGZ9              550 ----vGeeilgplgatesgrlaslegsLFEELLALLERLRGD-MLGRLLDAVMRDVKEKAQPY---CKdrWISLPS--QS 619 zebrafish
XP_003972690        554 llgglGlmelgql--------aalegsLFDSLLALLDRLKGD-MMGRLLDWTMREFKEKAKPY---SQnrWLSFPS--QQ 619
XP_003455706        558 ipgglGimemgrl--------aslegsLFDGLLALLDRLKGD-MLGRLLDFLMREIKEKAKPY---CQerWLSLPS--QQ 623
WGS:AATM:SJAG_01166 476 laeesS---------------------VFLPLRKRLSKLCNQ-TFELLMHRVTQYLEATFDSFA--SIntWtlqekppsd 531
Q9C0W8              480 ---------------------------AFYQVKPRLSTLTNG-SFRMILRAVSQTLRPLLDNYS--DLdtWvikeqlpga 529 Schizosa...
3FHN_A              552 d-eNIGPSSvpsaELVNSINVLRRLINKLDSXDiPLAISLKVKNELLNVIVNYFTESILKLNKFNQNGLNQFLHDF-KSL 629 baker's ...
XP_015787512        553 d----DMQY----ISYQLFYLISKSLELLKRKL-SHNILEELIETIADSIKTAIMKEVIYNNSFNGEGAQQLHRDVnINL 623
EDO38509            563 elaVMVLSS----GACDFLVYLKDRLNTLQKLL-AYKLFSALWVDLARALNMLIYQEVIQECRYNEGGAAQLQFDM-KNL 636
ELK01327            624 eqaVMSLSS----SACPLLLTLRDRLLQLEQQL-CISLFKIFWQMLAEKLDIYIYQEIILANHFNEGGASQLQFDMtRNL 698
XP_015207675        546 dqaTMSLSS----SACPMMLCLRDRLLQLQQLL-CVPLFQSCWQGLAERLDLFIYQEVILSSHFNEGGAAQLQFDMtRNL 620
Q5RGZ9              620 dqaTMSLSS----SACPMMLCLRDHLLQLQQML-CLPLFQMFWQGLAERLDCFIYEDLILYNHFNEGGAAQLQYDMtRNL 694 zebrafish
XP_003972690        620 dqsSMSLSS----SACPMMLCLRDRLLSLHQLL-GLSLFQLTWQGLAERLDHFLYQDVILANHFSDGGAAQLHFDMsRNL 694
XP_003455706        624 dqsTMSLSS----TACPMMLCVRDRLLNLHQVL-GFSLFHLAWQGLAERLDNFLYQDVILCNNFSDGGAAQLQFDMtRNL 698
WGS:AATM:SJAG_01166 532 ksyEGSISP----EAVGFDIALRRLINSIHEII-LGAPFFEIVCRIADIVEDWLLH-IMHTHQFSNRGAVQFARDSlQFL 605
Q9C0W8              530 allSTSVSA----EIVGFQSRLKEIIALLQKLL-IGSSQCEAIYQIGTLVESWMIK-IVMTHQFSVRGGVQFAMDAmQIV 603 Schizosa...
3FHN_A              630 SSilsLPSHATN---YKCXSLHELVKILKLKYD------PN-NQQFlnpeyiktgnfTS-----------LKEAYS---- 684 baker's ...
XP_015787512        624 FS---VFRVYTPnpeSLIIELVEACQLLNLAKGnslllqDTlRKGNvs--------------------ddILKDFN---- 676
EDO38509            637 FT---LFGEYTQkpeNYYKEVKECCILLNQMPGsailliESlQAAHahdest-------------napqaTLNEMG---- 696
ELK01327            699 FP---LFSHYCKrpeNYFKHVKEACIVLNLNIGsalllkDVlQsasgq-----------------ppataALNEVG---- 754
XP_015207675        621 FP---LFGHYCKrpeNFFKHVKEACIVLSLSVGsalllrDVlQQGDsgsdvtsd--------psqpspvaALNEVG---- 685
Q5RGZ9              695 FP---LFGHYCKrpeNFFKHVKEACIILTLKVGpallllDVlK--Qseedslpn--------hqqsspesALNELG---- 757 zebrafish
XP_003972690        695 FP---LFGQYCKrpeNFFKHVKEACIILRLSVGsaillrNVlEEAEeetd----agdHErpt-----lmsTLHELG---- 758
XP_003455706        699 FP---LFGHYCKkpeNFFKHVKEACIILCLNVGsaillrSLiKESDm---------tRDcagtgdpppesALNELG---- 762
WGS:AATM:SJAG_01166 606 TA----FSDYPl---VQMKRLTSSLPLLTFEqtekl------------------------------cikdLLRQINngdy 648
Q9C0W8              604 LE----FSDYPl---LKFERLMSTVELLSLESGenkl------------------------------ikkLIIEINqkny 646 Schizosa...
3FHN_A              685 -----------IK-Y--LKDTKIQDALYRI 700 baker's yeast
XP_015787512        677 -----------VH-H--LSAKVAHKILSKR 692
EDO38509            697 -----------VY-K--LSSHDALRILNLR 712
ELK01327            755 -----------IY-K--LAQHDVEILLNLR 770
XP_015207675        686 -----------IY-K--LSPGDVLILLNLR 701
Q5RGZ9              758 -----------IY-K--LAPSDVQILLNLR 773 zebrafish
XP_003972690        759 -----------VY-C--LAPCDVLYVLRLR 774
XP_003455706        763 -----------VY-C--LAPCDVLILLSLR 778
WGS:AATM:SJAG_01166 649 e------tlktINpEntLSPSESLDVLYRR 672
Q9C0W8              647 dfideffktkeIT----LSYEDALGVLYRR 672 Schizosaccharomyces pombe 972h-
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