Conserved Protein Domain Family
TGF_beta_GDF1_3_like
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cd13764: TGF_beta_GDF1_3_like 
transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins
The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.
Links
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Statistics
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PSSM-Id: 381642
Aligned: 9 rows
Threshold Bit Score: 194.991
Created: 16-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # #   ## #         # ###                    ##  ## ##  #    ##  # ##  #    
Q9NR23       264 CHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLti----slNSSNYAFMQALMHAVDPe-IPQAVCIPTKLSPIS 338 human
P35621       254 CKPRRLYIDFKDVGWQDWIIAPQGYLANYCHGECPFPLse----slNGTNHAILQTLVHSFDPkgTPQPCCVPIKLSPIS 329 zebrafish
P27539       267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPValsgsggpPALNHAVLRALMHAAAPgaADLPCCVPARLSPIS 346 human
P09534       259 CKKRHLYVEFKDVGWQNWVIAPQGYMANYCYGECPYPLte----ilNGSNHAILQTLVHSIEPedIPLPCCVPTKMSPIS 334 African clawed ...
AAC60038     272 CKPRRLYISFSDVGWENWIIAPQGYMANYCLGECPFPLta----elNSTNHAILQTMVHSLDPegTPQPCCVPVRLSPIS 347 chicken
Q9YGV1       253 CKKRRLYIDFKDVGWQNWVIAPRGYMANYCHGECPYPLte----mlRGTNHAVLQTLVHSVEPenTPLPCCAPTKLSPIS 328 African clawed ...
XP_005991183 253 CKKKRLYIEFKDVGWEDWIIAPQGYMANYCQGECPFPLse----slNGTNHAILQTLVHSFDPngTPQPCCVPIRLSPIS 328 coelacanth
XP_007903671 325 CQRRRLYLQFRDVGWQHWVIAPQGYMANYCYGECPFPLsd----rlNGTNHAILQTLVHSNHPtdTPQPCCVPIRLSPIS 400 elephant shark
XP_010410579   1 CKPRRLYISFSDVGWENWIIAPQGYLANYCRGDCPFPLaa----elNSTNHAVLQTMVHSLDPqgTPQPCCVPVRLSPIS 76  Corvus cornix c...

Feature 1                       ### #     #
Q9NR23       339 MLYQDNNDNVILRHYEDMVVDECGCG 364 human
P35621       330 MLYYDNNDNVVLRHYEDMVVDECGCR 355 zebrafish
P27539       347 VLFFDNSDNVVLRQYEDMVVDECGCR 372 human
P09534       335 MLFYDNNDNVVLRHYENMAVDECGCR 360 African clawed frog
AAC60038     348 ILYYDNSDNVVLRHYEDMVVDECGCR 373 chicken
Q9YGV1       329 MLYYDNNDNVVLRHYEDMVVDECGCK 354 African clawed frog
XP_005991183 329 MLYYDNNSNVILRHYEEMVVDECGCR 354 coelacanth
XP_007903671 401 MLYYDNNDNVVLRHYDDMVVDECGCR 426 elephant shark
XP_010410579  77 ILYYDNSDNVVLRHYQDMVVDECGCR 102 Corvus cornix cornix

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