4XGU,5VQ9,5WC2


Conserved Protein Domain Family
RecA-like_Pch2-like
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cd19508: RecA-like_Pch2-like 
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains
Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion
Links
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Statistics
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PSSM-Id: 410916
Aligned: 9 rows
Threshold Bit Score: 308.992
Created: 27-Nov-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindinghexamer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site
Evidence:
  • Structure:5WC2; Homo sapiens TRIP13 with bound ATP, contacts at 4A
  • Comment:contains Walker A and Walker B motifs
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #   ###      
4XGU_A       121 GSQLWQLpcveFDSIWENLIYDSNLKNEVMSYVAALArl--------seKHVNTKIINVNRLILLTGPPGTGKTSLCKGL 192 Caenorhabditis ...
NP_001320058 151 SFNEWILpakeFDGLWESLIYESGLKQRLLRYAASALlf--------tqKGVNPNLVSWNRIILLHGPPGTGKTSLCKAL 222 thale cress
Q6PH52       113 AANLWLLpaveFHGVWESLIYEEGIKTQLLDYVSTTIff--------sdKNVDSNLIAWNRVVLLHGPPGTGKTSLCKGL 184 zebrafish
Q6P4W8       121 AANHWLLpaadFHGLWDSLIYDSEIKSRLLDYIETAMlf--------sdKNVDSNLISWNRVVLLHGPPGTGKTSLCKAL 192 western clawed ...
NP_524282    115 AASHALLpaaqFVGLWENLIYETGLKEKLLKFALSALmf--------seHRVDTNVIACNRLILLHGPPGTGKTSLCKAL 186 fruit fly
E1C6Q1       121 AANHWVLpaaeFHGLWESLIYDTEVKSHLLDYVTTTLlf--------sdRNVDSNLISWNRVVLLHGPPGTGKTSLCKAL 192 chicken
5VQ9_D       121 AANHWVLpaaeFHGLWDSLVYDVEVKSHLLDYVMTTLlf--------sdKNVNSNLITWNRVVLLHGPPGTGKTSLCKAL 192 human
NP_009745    248 LVNISYLpgttFEGQWESLYFGNNIKERLYSYATISLkiarfkqtgdsnQEDITTLITNNKLLLVHGPPGTGKTTLCKAL 327 Saccharomyces c...
5WC2_A       121 AANHWVLpaaeFHGLWDSLVYDVEVKSHLLDYVMTTLlf--------sdKNVNSNLITWNRVVLLHGPPGTGKTSLCKAL 192 human

Feature 1                                  # ##                                        ##        
4XGU_A       193 AQHLsirmnd--------kysksVMLEINSHSLFSKWFSESGKLVQKMFDQIDElaed---ekcmVFVLIDEVEslgmcr 261 Caenorhabditis ...
NP_001320058 223 AQKLsircns--------ryphcQLIEVNAHSLFSKWFSESGKLVAKLFQKIQEmvee---dgnlVFVLIDEVEslaaar 291 thale cress
Q6PH52       185 AQKLsirlsd--------ryahsQFVEINSHSLFSKWFSESGKLVTKMFQKIQElidd---kdalVFVLIDEVEsltaar 253 zebrafish
Q6P4W8       193 AQKLtirlsy--------ryrygQLVEINSHSLFSKWFSESGKLVTKMFQKIHElind---kealVFVLIDEVEsltaar 261 western clawed ...
NP_524282    187 AQKLsirtqg--------syaytHLVEINSHSLFSKWFSESGKLVAQLFNKIAElvsd---pnnlVCVLIDEVEslayar 255 fruit fly
E1C6Q1       193 AQKLtirlsy--------ryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQElidd---kdalVFVLIDEVEsltaar 261 chicken
5VQ9_D       193 AQKLtirlss--------ryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDlidd---kdalVFVLIDQVEsltaar 261 human
NP_009745    328 CQKLsvrrefsdgsdtidtnykgIIIELSCARIFSKWFGESSKNISIVFKDIEEllkvnegrgifICLLIDEVEaiassr 407 Saccharomyces c...
5WC2_A       193 AQKLtirlss--------ryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQDlidd---kdalVFVLIDAVEsltaar 261 human

Feature 1                                                                   
4XGU_A       262 essssrsepsdaiRAVNALLTQIDRIRrrdnvLILCTSNle-stLDKALVDRADIVKNV 319 Caenorhabditis elegans
NP_001320058 292 kaalsgsepsdsiRVVNALLTQMDKLKsa-pnVIILTTSnittaIDVAFVDRADIKAYV 349 thale cress
Q6PH52       254 saaqagtepsdaiRVVNSVLTQLDQIKrh-pnVVILTTSnvtekIDLAFVDRADIKQYI 311 zebrafish
Q6P4W8       262 kasragtepsdaiRVVNAVLTQIDHIKry-pnVVILSTSnltekIDVAFTDRADIKQYI 319 western clawed frog
NP_524282    256 sam-ssneprdamRVVNAVLTQLDSLKtcpnvLILATSNla-qsIDLAFVDRADIRLFI 312 fruit fly
E1C6Q1       262 safkagtepsdaiRVVNAVLMQIDQIKry-pnVVILTTSnitekIDMAFVDRADIKQYI 319 chicken
5VQ9_D       262 nacragtepsdaiRVVNAVLTQIDQIKrh-snVVILTTSnitekIDVAFVDRADIKQYI 319 human
NP_009745    408 tnlssrnestdgiRVVNTLLTQLDRLKkyhnfLALATSNll-dsLDDAFVDRADGVFYV 465 Saccharomyces cerevisiae S288c
5WC2_A       262 nacragtepsdaiRVVNAVLTQIDQIKrhsnvVILTTSNit-ekIDVAFVDRADIKQYI 319 human

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