Conserved Protein Domain Family
PR-SET_PRDM8

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cd19192: PR-SET_PRDM8 
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins
PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.
Statistics
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PSSM-Id: 380969
Aligned: 11 rows
Threshold Bit Score: 171.845
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeputative SAMcatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            ###                #                      ## 
Q9NQV8          5 GIQRGIWDGDakavq---------------qcltdIFTSVYTTCDIPENAIFGPCVLSHTSLyd-siAFIALKSTDKRTV 68   human
EMP25860        5 GVQKGIWDGDakavq---------------qcltdIFTSVYTTCDIPENAIFGPCVLSHTSLyd-siAFIALKSTDKRTV 68   green sea turtle
OCU00363        8 GVQKPIWDGDakavq---------------qcltdIFTSVYTTCDIPENAIFGPCVLSHTSLyd-siAFIALKSTDKRTV 71   African clawe...
AAH55201        5 IFPRSLWTNDskilh---------------hhvadFFSSVQVTQDIPAGTSFGPCVLHNTFYdt--iAFIALKSFDKRNK 67   zebrafish
EEN66983      795 PSPRRLLRGQrmgqtmdegreirgqtmtderdsteLLTGVWTTTDIPPRTVFGPYVSGTDDVdp--aVLIGIRTKDKRMV 872  Florida lancelet
XP_006002810    5 SAHKGIWDGDaktvq---------------qcltdIFTSVYTTCDIPENAIFGPCVLSHTSLyd-siAFIALKSAEKRTV 68   coelacanth
XP_007895160    5 SIHKGIWESDaskavq--------------qcltdIFTSVYTTCDIPEHAIFGPCILSHTSLyd-siAFIALKSTDKRTV 69   elephant shark
KOF67609       70 FSKESILSSGsts--------------------adGHSTVVTSCEVPAFTIVGTYALDFQIGft--tADEPNITRVVEVK 127  Octopus bimac...
XP_022294657    5 VSGSKLTMSTlpsp------------------ldpPSIRVVTRTSIPPGCVAGPYPGEFQFGrn--tTDEVPNTAVYKVK 64   eastern oyster
CEP16117       13 MIHCNLQEAGg------------------------RCSAVRAATDLPAGLLLGVCPASLALHlgihcTDDLRSPDVVFQV 68   Dumeril's cla...
XP_022107599   55 HASPMLGRAGsak-------------------gsdIETSVWTSTEIPADVSFGPFDGEFRLGaa--mKDCRDSPYMLEVK 113  crown-of-thor...
Feature 1         #####                                  ##### #        ##                        
Q9NQV8         69 PYIFRVDTSaangs------------------seglMWLRLVQSARDKEEQNLEAYIKN-----GQLFYRSLRRIAKDEE 125  human
EMP25860       69 PYIFRVDTSaangs------------------seglMWLRLVQSARDKEEQNLEAYIKN-----GQLFYRSLRRIAKDEE 125  green sea turtle
OCU00363       72 PYIFRVDTLaangs------------------seglMWLRLVQSARNKEEQNLEAYIKN-----GQLFYRSLRRISKDEE 128  African clawe...
AAH55201       68 SYVFRVDPEamkgs------------------plvvPWLRLVQAAMSEEDQNTEAYLKG-----GQLHFRTIRDVKEGEE 124  zebrafish
EEN66983      873 SYAYKVDPGccrea------------------getlKWLRLIQPARDRREQNMEAFQRA-----GKVYFRSVCHIRRDEE 929  Florida lancelet
XP_006002810   69 PYIFRVDTSvangs------------------seglMWLRLVQSARDTEEQNLEAYVKN-----GQLFYRSLRRIAKDEE 125  coelacanth
XP_007895160   70 PYIFRVDTSaansn------------------seglMWLRLVQSARDKEEQNLEAYVKN-----GQLLYRSLRRIDKDEE 126  elephant shark
KOF67609      128 YVNGKLITSdg-----------------------ssNWLRHVQPARDRHEQNVEVFCDNetsgcKRVTVRTLRSVQKGEQ 184  Octopus bimac...
XP_022294657   65 FQDDTIVSElea----------------------tsDWMKGVRAARDRHEQNAEFFRSAd---dRGVYLRTLRKLRGGEE 119  eastern oyster
CEP16117       69 RYQNGAVKGwcgegplssgppssaaatspgshcspsDWLMAMQPARDMHEQNVEVSTPDph--sSVVRLQTVRRVPQGHT 146  Dumeril's cla...
XP_022107599  114 YSEGRLVSGpds---------------------hptRWMRFVAAAHDDHEQNLSAVRSPe----GRVMFRTNRSILRGEE 168  crown-of-thor...
Feature 1             ## ## ## 
Q9NQV8        126 LLVWYGKELTELL 138  human
EMP25860      126 LLVWYGKELTELL 138  green sea turtle
OCU00363      129 LLVWYGKELTDLL 141  African clawed frog
AAH55201      125 LLVWYDEELSHLL 137  zebrafish
EEN66983      930 LLVWYSDDWAVNI 942  Florida lancelet
XP_006002810  126 LLVWYGKELTELL 138  coelacanth
XP_007895160  127 LLVWYGKELSELL 139  elephant shark
KOF67609      185 LFVWYSDQLARST 197  Octopus bimaculoides
XP_022294657  120 LLAWYSEDLAIKC 132  eastern oyster
CEP16117      147 LMVWFSDTLASLH 159  Dumeril's clam worm
XP_022107599  169 LLVWYTNAFAEYL 181  crown-of-thorns starfish

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