Conserved Protein Domain Family
NDPk6
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cd04414: NDPk6 
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.
Links
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Statistics
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PSSM-Id: 239877
Aligned: 9 rows
Threshold Bit Score: 226.512
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitemultimer
Feature 1:active site [active site]
Evidence:
  • Comment:NDKs possess the active site motif N-x-x-H-[GA]-S-D.
  • Comment:His residue is phosphorylated during catalysis
  • Citation:PMID 8747457
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                         #       #                      
12232627   12 QLTLALIKPDAVAhp-lILEAVHQQILsnKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHkD 90  human
EAT44537    7 AFTLAIFKPHLLKnp-vAYGAVERLIKssGMRIVTRKQVHLTQPEAEQFYRDHQGKFFYRRLISLMTSGPLEVLVLSGeN 85  yellow fever mosquito
8308035     8 QLTLAVIKPDAMAhp-lILEALHQKILe-NFIIIRKTDLIWRTADSEMFYAEHQGRSSFKRLVEFMSTGQMRAYILAReD 85  zebrafish
XP_972639   5 ELTFAILKPHVIKqp-lAVEKIRNIILtsNFKVVKSKRHTIQLHEAESFYHEHKTKFFYKRLVTFMTSGPSDFYILAReD 83  red flour beetle
AAX09325    8 QLTFAILKPDLMLrp-lAAHTVRTLMIreGLWIVRSALLRWETEDAQKFYAEHEGKFFYDRLVSYMTSGPINPMILAHpN 86  Suberites domuncula
7595829     2 EITLALIKPHVLRnt-yAMQQIRALISq-NFTILDQKEVCITKELSERFYAEHKGKFFYHRLTSFMNSGPSYALILQSeT 79  fruit fly
XP_424474  12 QLTLALLKPDAVAhp-lVLEAVHETILsnRLLIVRAKELRCGREQSRRFYREHAGQFFYQRLVEFMASGPMWAYILAHeN 90  chicken
AAS15573    5 EKTFALIKPDAVRa--gKAQEIMQLIElnGFTIIAKQKLQLTRARAEEFYGEHKGKEFFPKLVNFMTSGPIWALVLAKpG 82  Chlamydomonas rein...
XP_760135 137 QLTLALIKPSVCSyqpdVSSILKLIKCs-RLSIARTRRLFWTSLDAHSFYAEHRGRFYYDRLILGMISGPSLALALYGpN 215 Ustilago maydis 521

Feature 1          #     #             #         #  # ##       #      
12232627   91 AIQLWRTLMGPTRVFRArhvAPDSIRGSFGLTDTRNTTHGSDSvVSASREIAAFFP 146 human
EAT44537   86 VINRWRELMGPTKVFKAvysNPECIRSLYGLTDTRNASHGSDSvASFQTEAALFFP 141 yellow fever mosquito
8308035    86 AITHWRTMMGPTKVFRArfsSPETLRGKYGLTDTRNTTHGSDSiESAKREISFFFP 141 zebrafish
XP_972639  84 AIKTWRQLMGPTKVFKTqfeAPDSIRGQFGLSDTRNATHGSDSpESVKKEIGLFFP 139 red flour beetle
AAX09325   87 AVETWRKMMGPTKSYVAqatAPDSIRGQFGLSDTRNSTHGADSdASAQREMQILFP 142 Suberites domuncula
7595829    80 CIQKWRSLLGPTKVFRAvysDPNCIRALYGISDTRNACHGSDSeASALREISILFP 135 fruit fly
XP_424474  91 AISLWRSLMGPTKVFRArncVPDSIRGAYGLTDTRNTTHGSDSpASASREIAFFFP 146 chicken
AAS15573   83 AILAWRALMGPTNVFKAraeQPKCLRALYGTDGTQNATHGSDSpISAAREIKFFFP 138 Chlamydomonas reinhardtii
XP_760135 216 AIKEWRAMLGPTKAYIGkhtMPASLRAKYGLGDTRNGFHGSDSpESARRELGLVFD 271 Ustilago maydis 521

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