19075551 273 SRDLQVEKLSVSA--WGKLLIKDSELNLINGRRYGLIAPNGSGKSTLLHAIA---------CGLIPTPSS-LDFYLLDRE 340 fission yeast 15893818 1 MSLINVTNLTFAYegSYDNIFENVSFQIDTDWKLGFTGRNGRGKTTFLNLLLgky----eyNGSISTDVN---FEYFPYE 73 Clostridium aceto... 19553340 5 AAYIAIDGLSFSY--PNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAgvm---epdQGRIYLP---ERTGFIAQE 76 Corynebacterium g... 15672881 1 MSNIEFKDLTFGY--GDNLIFNHAQINIDDRWKLGLVGRNGRGKSTLLNLLQgki----ttDSSITTDKNfVYFPQLLTE 74 Lactococcus lacti... 15901142 10 NHMIKINHLTITQnkDLRDLVSDLTMTIQDGEKVAIIGEEGNGKSTLLKILMgealsdftiKGNIQSDYQ--SLAYIPQK 87 Streptococcus pne... 19114521 442 eeELVNTDFSLAYg--GRLLLSHTNLHLYRGHRYGVVGHNGCGKSTLLRAIGdyk---venFPSPDEVKT-CFVAHSLQG 515 fission yeast 15213983 432 GEDLCNCEFSLAYg--AKILLNRTRLRLKRGRRYGLCGPNGSGKSTLMRAIVngq---vegFPT--HLRT-VYVEHDIDE 503 fission yeast 119180 428 GEDLCNCEFSLAYg--AKILLNKTQLRLKRARRYGICGPNGCGKSTLMRAIAngq---vdgFPTQEECRT-VYVEHDIDG 501 baker's yeast 1706591 428 GEDLCNCEFSLAYg--AKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRSIAngq---vdgFPTQDECRT-VYVEHDIDN 501 baker's yeast 6325030 569 GIEIVNTDFSLAYg--SRMLLNKTNLRLLKGHRYGLCGRNGAGKSTLMRAIAngq---ldgFPDKDTLRT-CFVEHKLQG 642 baker's yeast
19075551 341 YIPNEL-TCVEAVLDINEQERKHLEAMMEDLLDDPDK------NAVELDTIQTRLTDLET---ENSDHRVYKILRGLQFT 410 fission yeast 15893818 74 VQEKGK-----FVIDVIKEISPNSMDWEIVK---------------------------------------ELSLLDIDYE 109 Clostridium aceto... 19553340 77 TDLPFEqPVQSLIDAAVAPVRAVDAAITDLSTKLGDAslsaeeQAQVATDFDAALGAAEElglWELDARIETIVAGLGLA 156 Corynebacterium g... 15672881 75 EDFNDKdKSKKQNTADKYSVESLSVKITDRNS-------------QLTYYVLNELAEFEQ---WKLErELSLLKVDLEIL 138 Lactococcus lacti... 15901142 88 VPED----LKKKTLHDYFFLDSIDLDYSILYR-----------------------------------LAEELHFDSNRFA 128 Streptococcus pne... 19114521 516 EDTSm-------------------------------------------AILDFVAQDKAlltmNVTRQEAADALHSVGFT 552 fission yeast 15213983 504 SEADt-------------------------------------------PSVDFILQDPAvp--ikDRDEIVKALKENSFT 538 fission yeast 119180 502 THSDt-------------------------------------------SVLDFVFESgv-----gTKEAIKDKLIEFGFT 533 baker's yeast 1706591 502 THSDm-------------------------------------------SVLDFVYSGnv-----gTKDVITSKLKEFGFS 533 baker's yeast 6325030 643 EEGDl-------------------------------------------DLVSFIALDEElq--stSREEIAAALESVGFD 677 baker's yeast
19075551 411 DEmiAKRTNELSGGWRMRIALARILFIKPTLMMLDEPTNHLDLEAVAWLEEYLThEMEGhTLLITCHTQDTLNEVCTDII 490 fission yeast 15893818 110 AL--YRQFYTLSKGEQTKSLLAAMFLKENSFLLIDEPTNHLDAEGRKKLSNYLK-KKKG--FILISHDRSFLDNCVDHIL 184 Clostridium aceto... 19553340 157 EVdrSTPIGELSGGQRRRFALAALLLEPHDALIFDEPTNHLDDTAVDFLISEIS-RFKG-PVLIASHDRFFLDSVCTELI 234 Corynebacterium g... 15672881 139 WR----PFGSLSGGEQTKCLLAILFLDEDNFPLIDEPTNQLDLESRKIVADYLQ-KKSG--FIVVSHDRNFLDEVCDHTL 211 Lactococcus lacti... 15901142 129 S---DQEIGNLSGGEALKIQLIHELAKPFEILFLDEPSNDLDLETVDWLKGQIQkTRQT--VIFISHDEDFLSETADTIV 203 Streptococcus pne... 19114521 553 AEmqENPVASLSGGWKMKLELARAMLQKADILLLDEPTNHLDVANIAWLEAYLT-SQKNiTCLIVSHDSSFLDHVCTDII 631 fission yeast 15213983 539 DEliNMPIGSLSGGWKMKLALTRAMFKNPDILLLDEPTNHLDVVNVAWLENFLV-NQKDvSSIIVSHDSGFLDHVVQAII 617 fission yeast 119180 534 DEmiAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYL--NTCGiTSITISHDSVFLDNVCEYII 611 baker's yeast 1706591 534 DEmiEMPIASLSGGWKMKLALARAVLKDADILLLDEPTNHLDTVNVEWLVNYL--NTCGiTSVIVSHDSGFLDKVCQYII 611 baker's yeast 6325030 678 EErrAQTVGSLSGGWKMKLELARAMLQKADILLLDEPTNHLDVSNVKWLEEYLL-EHTDiTSLIVSHDSGFLDTVCTDII 756 baker's yeast
19075551 491 HLYHQ------------KLDYYSG-NYDTFLKVRAERD--------VQLAKKARQ-------QEKDMAKLQNKLNMTGSE 542 fission yeast 15893818 185 SINRT------------NIEIQKG-NFSSWWRNKELKDgf-----eLAENEKLKKdinrlssSAKRTSTWSDSVESSKYG 246 Clostridium aceto... 19553340 235 DLDPAlgpeggsgeevkQAVSFGG-GFSEYIKERETRR--------TRWAQLYTA-------QETEREKLEETTGTTESD 298 Corynebacterium g... 15672881 212 AIERQ------------QIVLYQG-NFSTYEREKQLRD--------DFELAEDEKlrkdisrLKKTSLEKRDWSNQRENV 270 Lactococcus lacti... 15901142 204 HLRLVkhr-------keAETLVEHlDYDSYSEQRKANFak-----qSQQAANNQRaydktmeKHRRVKQNVETALRATKD 271 Streptococcus pne... 19114521 632 HYEGVknq-------akKLGYYQG-NLSAFVKVKPEAKsyytltatNEKFVFPPPgil--tgVRSNTRLILKMTNASYTY 701 fission yeast 15213983 618 HYERf------------KLRKYLG-NMSEFVKKVPSAKsyyelgasEMEFKFPEPgfl--egVKTKQRAIIKVQHMSFQY 682 fission yeast 119180 612 NYEGl------------KLRKYKG-NFTEFVKKCPAAKayeelsntDLEFKFPEPgyl--egVKTKQKAIVKVTNMEFQY 676 baker's yeast 1706591 612 HYEGl------------KLRKYKG-NLSEFVQKCPTAQsyyelgasDLEFQFPTPgyl--egVKTKQKAIVKVSNMTFQY 676 baker's yeast 6325030 757 HYEn------------kKLAYYKG-NLAAFVEQKPEAKsyytltdsNAQMRFPPPgil--tgVKSNTRAVAKMTDVTFSY 821 baker's yeast
19075551 543 QQKKa--------kAKVKAMNKKLEKDKQSg----KVLDEEIIQEKQLVIRFEDCGG--------------GIPSPAIKF 596 fission yeast 15893818 247 TTNSgskldkgyvgHKSEKMMKRAKNIEARqqnmiKEKSRLLKNIENNENLKIVPLT--------------FHDKKLVEV 312 Clostridium aceto... 19553340 299 IFHS----------SVSKSEAKITAKFYAD-----RAAKTQGNRVRSAKNRLKELERye-----------iPAPPKPLEF 352 Corynebacterium g... 15672881 271 AGATfvdk---kvaKKQNQRAKSIEKRMGQevenkEKLLKNIEKTEPLIMNFQPSHH-----------------KRLIQF 330 Lactococcus lacti... 15901142 272 STAGrl------laKKMKTVLSQEKRYEKAa----QSMTQKPLEEEQIQLFFSDIQPl-------------PASKVLVQL 328 Streptococcus pne... 19114521 702 PNAk----------KKSLDNVTVGLSLSSR-----VAILGPNGAGKSTLIKVLIGEVipqegkvfkhpnlrVGYVAQHAF 766 fission yeast 15213983 683 PGTs----------KPQLNDISFQVSLSSR-----IAVIGPNGAGKSTLIKVLTGELlptvgeiyqhencrIAYVAQAAF 747 fission yeast 119180 677 PGTs----------KPQITDINFQCSLSSR-----IAVIGPNGAGKSTLINVLTGELlptsgevythencrIAYIKQHAF 741 baker's yeast 1706591 677 PGTt----------KPQVSDVTFQCSLSSR-----IAVIGPNGAGKSTLINVLTGELlptsgevythencrIAYIKQHAF 741 baker's yeast 6325030 822 PGAq----------KPSLSHVSCSLSLSSR-----VACLGPNGAGKSTLIKLLTGELvpnegkvekhpnlrIGYIAQHAL 886 baker's yeast
19075551 597 QDVSFNYPGG------------PTIFSKLNFGLDLKSRVALVGPNGAGKTTLIKLILEKVQPS----TGSVVRHHG-LRL 659 fission yeast 15893818 313 IDVAIKYDDR-------------IVCEGVRFNIEKGERIAIQGKNGSGKSSILKLIYGEDIPH----SGIVRKNNK-LII 374 Clostridium aceto... 19553340 353 QGIPEASGNGhgetlevraiavENRLQPLTFHIDPGDHILVEGPNGVGKSTLLSVLEGVLEPT----EGELIVPEG-LKV 427 Corynebacterium g... 15672881 331 ENFSLGFTEK-------------LLFQPIDFSLKVGEIAAIVGPNGQGKSSIFKYLSGDFSGEh---SGFVQFPQG-IRL 393 Lactococcus lacti... 15901142 329 EKENLSIDDR-------------VLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKL-----------QRLLNDKRE-ISL 383 Streptococcus pne... 19114521 767 HHLDQHLEKTp----------sQYIQWRYAGGQDREVSEKESRKLTEEDRAQLQRDITVN-GErr-rVEALIGRQKlKKS 834 fission yeast 15213983 748 THLGHHPDKTp----------sEYIQWRFQSGEDLEAMDKASRVISEADEEAMKNKIFKIEGTqr-kILGIHSRRKlKNS 816 fission yeast 119180 742 AHIESHLDKTp----------sEYIQWRFQTGEDRETMDRANRQINENDAEAMN-KIFKIEGTpr-rIAGIHSRRKfKNT 809 baker's yeast 1706591 742 AHIESHLDKTp----------sEYIQWRFQTGEDRETMDRANRQINENDAEAMN-KIFKIEGTpr-rVAGIHSRRKfKNT 809 baker's yeast 6325030 887 QHVNEHKEKTa----------nQYLQWRYQFGDDREVLLKESRKISEDEKEMMTKEIDIDDGRgkraIEAIVGRQKlKKS 956 baker's yeast
19075551 660 ALFNQHMg-------------------DQLD----MRL-------SAVEWLRTKFGNKP-----EGEMRRIVGRYGLTGK 704 fission yeast 15893818 375 SYVSQDT--------------------SDLYg-------------NLSEYADKYCID-------ETLFKSMLRKLDFSRE 414 Clostridium aceto... 19553340 428 ARLKQDD---------------------QWT----EKQl-----nTPVDELFAALS--------KGPVGLNLVEMGLLRE 469 Corynebacterium g... 15672881 394 SFVRQIY--------------------DNRG--------------YLKDFATEYQLN-------YELFLANLRKLGMECK 432 Lactococcus lacti... 15901142 384 GFMPQDYh-------------------KKLQ----LDL-------SPIAYLSKTGEKEE-----LQKIQSHLASLNFSYP 428 Streptococcus pne... 19114521 835 FQYEIKWfgkp-------------hkyNTWVsreiLLEngfqkfvQAFDDMESSREGLGfreliPEDIRAHFEDVGLPGD 901 fission yeast 15213983 817 YEYECSFlvgenigmkserwvpmmssdNAWLprgeLMEtha-kmvAEVDRAEALKSGQfrp-lvRKEIEEHCSLLGLDAE 894 fission yeast 119180 810 YEYECSFllgenigmkserwvpmmsvdNAWIprgeLVEshs-kmvAEVDMKEALASGQfrp-ltRKEIEEHCSMLGLDPE 887 baker's yeast 1706591 810 YEYECSFllgenigmkserwvpmmsvdNAWLprgeLIEshs-kmvAEIDMKEALASGQfra-ltRKEIELHCAMLGLDSE 887 baker's yeast 6325030 957 FQYEVKWkywk-------------pkyNSWVpkdvLVEhgfeklvQKFDDHEASREGLGyreliPSVITKHFEDVGLDSE 1023 baker's yeast
19075551 705 SQ-VIPMGQLSDGQRRRVLFAFLGMTQPHILLLDEPTNALDIDTIDALADALNNFDGGVVFITHDFRLIDQVA-EEIWIV 782 fission yeast 15893818 415 QF-EKDIKDFSGGQKKKVLLAKSLCERAHLYIWDEPLNFIDVISRMQVEKLLIEYEPTILFVEHDISFCENVAtKTIKL- 492 Clostridium aceto... 19553340 470 TSqSSPLRALSLGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKRWTgKKISLS 549 Corynebacterium g... 15672881 433 QF-SQKIETMSQGQQKKVELARSLSQEAELYLWDEPLNYLDVFNREQIIQLLETYHPTMLLVEHDQAFVEKIS-NQIINL 510 Lactococcus lacti... 15901142 429 EM-QHQIRSLSGGQQGKLLLLDLVLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRFLKEVC-SIIYRM 506 Streptococcus pne... 19114521 902 IAdYSPISSLSGGQKVKVVIAACLWNNPQLLVLDEPTNFLDRDALGGLAVAIRDWEGGVVMISHNEEFVSALC-PEHWHV 980 fission yeast 15213983 895 LVsHSRIKGLSGGQKVKLVLAACTWLRPHVIVLDEPTNYLDRDSLGALSKGLKNFGGGVVLVTHSREFTEGLT-EEVWAV 973 fission yeast 119180 888 IVsHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKNLT-EEVWAV 966 baker's yeast 1706591 888 LVsHSRIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLT-DEVWAV 966 baker's yeast 6325030 1024 IAnHTPLGSLSGGQLVKVVIAGAMWNNPHLLVLDEPTNYLDRDSLGALAVAIRDWSGGVVMISHNNEFVGALC-PEQWIV 1102 baker's yeast
19075551 783 QNg--TVKEFDGEIRDYKMMLKQQ 804 fission yeast 15893818 ------------------------ Clostridium acetobutylicum 19553340 550 R----------------------- 550 Corynebacterium glutamicum ATCC 13032 15672881 511 KDt--------------------- 513 Lactococcus lactis subsp. lactis 15901142 507 TEhglKLVNLEDL----------- 519 Streptococcus pneumoniae TIGR4 19114521 981 E----AGKVTGKGKTAVDDGKFED 1000 fission yeast 15213983 974 N----NGHMTPSGHNWVSGQGSGP 993 fission yeast 119180 967 K----DGRMTPSGHNWVSGQGAGP 986 baker's yeast 1706591 967 K----DGKMTPSGHNWVAGQGAGP 986 baker's yeast 6325030 1103 E----NGKMVQKGSAQVDQSKFED 1122 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",