Conserved Protein Domain Family
bHLH_dnHLH_ID4
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cd19694: bHLH_dnHLH_ID4 
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins
ID4, also termed Class B basic helix-loop-helix protein 27 (bHLHb27), or inhibitor of DNA binding 4, or inhibitor of differentiation 4, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It plays a role in adipose cell differentiation.
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Statistics
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PSSM-Id: 381537
Aligned: 5 rows
Threshold Bit Score: 120.502
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:HLH region of bHLH forms homo- and heterodimers
  • Comment:Based on the structure evidence that Homo sapiens ID-2 (4AYA) forms a homodimer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  ##  ## ##  #           ##  ## ## ### ##  #   #     
P47928        58 DEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQ 117 human
Q7ZXF3        42 EEETLCLQYDMNDCYSRLKRLVPTIPPNKKVSKVEILQHVIDYILDLQLALDTHPVLLRQ 101 African clawed frog
AAI08046      34 DEDLFCLQYDMNDCYSRLKRLVPTIPQDKKVSKVEILQHVIDYILDLQLALETHPALLKQ 93  zebrafish
AAK93836      43 EPAALCLQCDMNDCYSRLRRLVPTIPPNKRVSKVEILQHVIDYILDLQLALETHPALLRQ 102 chicken
XP_006011407  38 EEESLCLQYDMNDCYTRLKRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPVLLRQ 97  coelacanth

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