4HPL,5JH5


Conserved Protein Domain Family
RAWUL_PCGF1

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cd17081: RAWUL_PCGF1 
RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 1 (PCGF1) and similar proteins
PCGF1, also termed nervous system Polycomb-1 (NSPc1), or RING finger protein 68 (RNF68), is one of six PcG RING finger (PCGF) homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR) and serves as the core component of a noncanonical Polycomb repressive complex 1 (PRC1)-like BCOR complex that also contains RING1, RNF2, RYBP, SKP1, as well as the BCL6 co-repressor BCOR and the histone demethylase KDM2B, and is required to maintain the transcriptionally repressive state of some genes, such as Hox genes, BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. PCGF1 promotes cell cycle progression and enhances cell proliferation as well. It is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the retinoid acid response element (RARE element). Moreover, PCGF1 functions as an epigenetic regulator involved in hematopoietic cell differentiation. It cooperates with the transcription factor runt-related transcription factor 1 (Runx1) in regulating differentiation and self-renewal of hematopoietic cells. Furthermore, PCGF1 represents a physical and functional link between Polycomb function and pluripotency. PCGF1 contains a C3HC4-type RING-HC finger and a RAWUL domain.
Statistics
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PSSM-Id: 340601
Aligned: 14 rows
Threshold Bit Score: 110.487
Created: 6-Jul-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:RAWUL-BCOR interaction site [polypeptide binding site]
Evidence:
  • Comment:Polycomb Group (PcG) proteins form repressive complexes that mediate epigenetic modifications of histones. The ubiquitin-like RAWUL domain of PCGF1 forms a selective complex with BCOR.
  • Structure:4HPL; Homo sapiens ubiquitin-like RAWUL domain of PCGF1 binds BCOR, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####                                   ####### ###   #  ##  ##                 
4HPL_B         4 REQLNLCLERLssgk------------------dknkSVLQNKYVRCSVRAEVRHLRRVLCHRLmln-pqHVQLLFDN-E 63  human
NP_001007159 164 DEQVSLCLERQsssfsg---------------kdknkLTLQQKFVRCSVRAEVRHLRKVLCHRLnve-khQVQMLFNN-E 226 zebrafish
NP_001089498 166 DEHVCLCLEKVssgk------------------dkkkFILQQKYVRCSVRSEIRHLRRVLSHRLsap-laQVQLLIDN-K 225 African clawed ...
XP_007904857 158 DEQVSLCLERHgsslg----------------kekgkLLLQQKYVRCSVRAEIRHLRRVLCHRInlvdqqQLQIMFDN-E 220 elephant shark
XP_006826060 160 DEQLSMCLERHsslivdd------------hegksylKPLHRKYLRCSVRTCVSHIRKLLVKKLaipkrlEVQVLCND-V 226 Saccoglossus ko...
XP_003724093 136 DEQVSLCLEYLgngpsra-------------eedagiTQLDKKYIRCSVRTCVYHLQKLLLKKLdvskdsEVLLYCED-E 201 purple urchin
XP_002603701 516 DEQVSMCLERHstcvvsese--------dedeirtymKPLQHKFIRCSVRAAVVHIKKLIVKKLavprrlEVEVLCNG-R 586 Florida lancelet
XP_013065966 136 DEQICLCLERYrsqgish------------cgkilplRSLDRKFLRCSIRVLVSHLKAMLYKKLaipsdvQVEVICDR-E 202 Biomphalaria gl...
KXJ15720     143 DELVSLCLERLgfsdneeaeasdveddkhsetpskhsKSLSKKHIRCSVRTMVFHLQKYLRTRLkippeqQVEIFCND-H 221 Exaiptasia pallida
XP_013406838  59 DELVSLCLERDslllplqn----------ingqpvhiPPLDRKFIRCSTRTRIAHVKKLLRKKLvlsqslKLTISCSEaS 128 Lingula anatina
Feature 1                   ##               
4HPL_B        64 VLPDHMTMKQIWLSRWFgkpsPLLLQYS 91  human
NP_001007159 227 SLPDHMTMKRLWLSHWFgkaqPLVLHYT 254 zebrafish
NP_001089498 226 VLPDHMTMKQLWLMHWYgkpaPLVLLYS 253 African clawed frog
XP_007904857 221 LLPEHMTMKQLWLSRWFdkptPMVLQYS 248 elephant shark
XP_006826060 227 VLPKNATMKYVWLSQWRglcaPMVLHYR 254 Saccoglossus kowalevskii
XP_003724093 202 ELYEEEPMKYIWVSHWKgkaaPMVLKYQ 229 purple urchin
XP_002603701 587 VLPKSVTMKYIWLSHWQakaaPMVLHYR 614 Florida lancelet
XP_013065966 203 VLADEVSMKQIFLMNWFgketPMVLYYR 230 Biomphalaria glabrata
KXJ15720     222 IIHPCRTMKFIWISEWJdrapPIVLHYD 249 Exaiptasia pallida
XP_013406838 129 GLDDNWNLKQIWLQHWLdkdpPLILYYA 156 Lingula anatina

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