Conserved Protein Domain Family
7tmA_OXR

?
cd15208: 7tmA_OXR 
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.
Statistics
?
PSSM-Id: 320336
Aligned: 13 rows
Threshold Bit Score: 413.324
Created: 29-Sep-2008
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

cd15208 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd15208 is a member of the superfamily cl28897
Sub-family Hierarchy
cd149647tm_GPCRscd006377tm_classA_rhodopsin-likecd139547tmA_ORcd152247tmA_OR6B-likecd152257tmA_OR10A-likecd152267tmA_OR4-likecd159357tmA_OR4Q3-likecd159367tmA_OR4D-likecd159377tmA_OR4N-likecd159387tmA_OR4Q2-likecd159397tmA_OR4A-likecd159407tmA_OR4E-likecd152277tmA_OR14-likecd152287tmA_OR10D-likecd152297tmA_OR8S1-likecd152307tmA_OR5-likecd154057tmA_OR8B-likecd154067tmA_OR8D-likecd154077tmA_OR5B-likecd154087tmA_OR5AK3-likecd154097tmA_OR5H-likecd154107tmA_OR5D-likecd154117tmA_OR8H-likecd154127tmA_OR5M-likecd154137tmA_OR8K-likecd154147tmA_OR5G-likecd154157tmA_OR5J-likecd154167tmA_OR5P-likecd154177tmA_OR5A1-likecd154187tmA_OR9G-likecd154197tmA_OR9K2-likecd159437tmA_OR5AP2-likecd159447tmA_OR5AR1-likecd159457tmA_OR5C1-likecd152317tmA_OR5V1-likecd152327tmA_OR13-likecd152337tmA_OR3A-likecd152377tmA_OR2-likecd154207tmA_OR2A-likecd154217tmA_OR2T-likecd154247tmA_OR2_unkcd154287tmA_OR2D-likecd154297tmA_OR2F-likecd154307tmA_OR13-likecd154317tmA_OR13H-likecd159467tmA_OR1330-likecd159477tmA_OR2B-likecd154327tmA_OR2B2-likecd154337tmA_OR2Y-likecd154347tmA_OR2W-likecd159117tmA_OR11A-likecd159127tmA_OR6C-likecd159137tmA_OR11G-likecd159147tmA_OR6N-likecd159157tmA_OR12D-likecd159167tmA_OR10G-likecd159417tmA_OR10S1-likecd159427tmA_OR10G6-likecd159177tmA_OR51_52-likecd152217tmA_OR52B-likecd152227tmA_OR51-likecd152237tmA_OR56-likecd159487tmA_OR52K-likecd159497tmA_OR52M-likecd159507tmA_OR52I-likecd159517tmA_OR52R_52L-likecd159527tmA_OR52E-likecd159537tmA_OR52P-likecd159547tmA_OR52N-likecd159557tmA_OR52A-likecd159567tmA_OR52W-likecd159187tmA_OR1_7-likecd152347tmA_OR7-likecd152357tmA_OR1A-likecd152367tmA_OR1E-likecd149677tmA_amine_R-likecd150487tmA_Histamine_H3R_H4Rcd152957tmA_Histamine_H4Rcd152967tmA_Histamine_H3Rcd150497tmA_mAChRcd152977tmA_mAChR_M2cd152987tmA_mAChR_M4cd152997tmA_mAChR_M3cd153007tmA_mAChR_M5cd153017tmA_mAChR_DM1-likecd153027tmA_mAChR_GAR-2-likecd177907tmA_mAChR_M1cd150507tmA_Histamine_H1Rcd150517tmA_Histamine_H2Rcd150527tmA_5-HT2cd153047tmA_5-HT2Acd153057tmA_5-HT2Ccd153067tmA_5-HT2Bcd153077tmA_5-HT2_insect-likecd150537tmA_D2-like_dopamine_Rcd153087tmA_D4_dopamine_Rcd153097tmA_D2_dopamine_Rcd153107tmA_D3_dopamine_Rcd150547tmA_5-HT6cd150557tmA_TAARscd153127tmA_TAAR2_3_4cd153147tmA_TAAR1cd153177tmA_TAAR5-likecd153167tmA_TAAR6_8_9cd153187tmA_TAAR5cd150567tmA_5-HT4cd150577tmA_D1-like_dopamine_Rcd153197tmA_D1B_dopamine_Rcd153207tmA_D1A_dopamine_Rcd150587tmA_Beta_ARcd159577tmA_Beta2_ARcd159587tmA_Beta1_ARcd159597tmA_Beta3_ARcd150597tmA_alpha2_ARcd153217tmA_alpha2B_ARcd153227tmA_alpha2A_ARcd153237tmA_alpha2C_ARcd153247tmA_alpha-2D_ARcd150607tmA_tyramine_octopamine_R-likecd150617tmA_tyramine_R-likecd150627tmA_alpha1_ARcd153257tmA_alpha1A_ARcd153267tmA_alpha1B_ARcd153277tmA_alpha1D_ARcd150637tmA_Octopamine_Rcd150647tmA_5-HT1_5_7cd153287tmA_5-HT5cd153297tmA_5-HT7cd153307tmA_5-HT1A_vertebratescd153317tmA_5-HT1A_invertebratescd153337tmA_5-HT1B_1Dcd153347tmA_5-HT1Fcd153357tmA_5-HT1Ecd150657tmA_Ap5-HTB1-likecd150667tmA_DmOct-betaAR-likecd150677tmA_Dop1R2-likecd149687tmA_Adenosine_Rcd150687tmA_Adenosine_R_A2Acd150697tmA_Adenosine_R_A2Bcd150707tmA_Adenosine_R_A3cd150717tmA_Adenosine_R_A1cd149697tmA_Opsins_type2_animalscd150727tmA_Retinal_GPRcd150737tmA_Peropsincd150747tmA_Opsin5_neuropsincd150757tmA_Parapinopsincd150767tmA_SWS1_opsincd150777tmA_SWS2_opsincd150787tmA_Encephalopsincd150807tmA_MWS_opsincd150817tmA_LWS_opsincd150827tmA_VA_opsincd150837tmA_Melanopsin-likecd150797tmA_photoreceptors_insectcd153367tmA_Melanopsincd153377tmA_Opsin_Gq_invertebratescd150847tmA_Pinopsincd150857tmA_Parietopsincd150867tmA_tmt_opsincd149707tmA_Opioid_R-likecd150877tmA_NPBWRcd150887tmA_MCHR-likecd153387tmA_MCHR1cd153397tmA_MCHR2cd150897tmA_Delta_opioid_Rcd150907tmA_Mu_opioid_Rcd150917tmA_Kappa_opioid_Rcd150927tmA_NOFQ_opioid_Rcd150937tmA_SSTRcd159707tmA_SSTR1cd159717tmA_SSTR2cd159727tmA_SSTR3cd159737tmA_SSTR4cd159747tmA_SSTR5cd150947tmA_AstC_insectcd149717tmA_Galanin_R-likecd150957tmA_KiSS1Rcd150967tmA_AstA_R_insectcd150977tmA_Gal2_Gal3_Rcd150987tmA_Gal1_Rcd149727tmA_EDG-likecd150997tmA_Cannabinoid_Rcd153407tmA_CB1cd153417tmA_CB2cd151007tmA_GPR3_GPR6_GPR12-likecd159607tmA_GPR185-likecd159617tmA_GPR12cd159627tmA_GPR6cd159637tmA_GPR3cd151017tmA_LPARcd153427tmA_LPAR2_Edg4cd153437tmA_LPAR3_Edg7cd153447tmA_LPAR1_Edg2cd151027tmA_S1PRcd153457tmA_S1PR3_Edg3cd153467tmA_S1PR1_Edg1cd153477tmA_S1PR2_Edg5cd153487tmA_S1PR5_Edg8cd153497tmA_S1PR4_Edg6cd151037tmA_MCRcd153507tmA_MC2R_ACTH_Rcd153517tmA_MC1Rcd153527tmA_MC3Rcd153537tmA_MC4Rcd153547tmA_MC5Rcd149737tmA_Mrgprcd151057tmA_MrgprAcd151067tmA_MrgprX-likecd151077tmA_MrgprBcd151087tmA_MrgprDcd151097tmA_MrgprFcd151107tmA_MrgprHcd151117tmA_MrgprGcd151127tmA_MrgprEcd151137tmA_MAS1Lcd149747tmA_Anaphylatoxin_R-likecd151147tmA_C5aRcd151157tmA_C3aRcd151167tmA_CMKLR1cd151177tmA_FPR-likecd151187tmA_PD2R2_CRTH2cd151197tmA_GPR1cd151207tmA_GPR33cd149757tmA_LTB4Rcd151217tmA_LTB4R1cd151227tmA_LTB4R2cd149767tmA_RNL3Rcd159257tmA_RNL3R2cd159267tmA_RNL3R1cd149777tmA_ET_R-likecd151267tmA_ETBR-LP2cd151277tmA_GPR37cd151287tmA_ET_Rcd159757tmA_ET-ARcd159767tmA_ET-BRcd159777tmA_ET-CRcd159277tmA_Bombesin_R-likecd151237tmA_BRS-3cd151247tmA_GRPRcd151257tmA_NMBRcd149797tmA_NTSR-likecd151307tmA_NTSRcd153557tmA_NTSR1cd153567tmA_NTSR2cd151337tmA_NMU-Rcd153577tmA_NMU-R2cd153587tmA_NMU-R1cd151347tmA_capaRcd151357tmA_GPR39cd159287tmA_GHSR-likecd151317tmA_GHSRcd151327tmA_motilin_Rcd149807tmA_Glycoprotein_LRR_R-likecd151367tmA_Glyco_hormone_Rcd153597tmA_LHCGRcd153607tmA_FSH-Rcd159647tmA_TSH-Rcd151377tmA_Relaxin_Rcd159657tmA_RXFP1_LGR7cd159667tmA_RXFP2_LGR8cd151387tmA_LRR_GPRcd153617tmA_LGR4cd153627tmA_LGR6cd153637tmA_LGR5cd149817tmA_Prostanoid_Rcd151397tmA_PGE2_EP2cd151407tmA_PGD2cd151417tmA_PGI2cd151427tmA_PGE2_EP4cd151437tmA_TXA2_Rcd151447tmA_PGE2_EP1cd151457tmA_FPcd151467tmA_PGE2_EP3cd149827tmA_purinoceptor-likecd149837tmA_FFARcd151697tmA_FFAR1cd151707tmA_FFAR2_FFAR3cd149917tmA_HCAR-likecd151997tmA_GPR31cd152007tmA_OXER1cd152017tmA_HCAR1-3cd149947tmA_GPR141cd149967tmA_GPR82cd151477tmA_PAFRcd151487tmA_GPR34-likecd151527tmA_GPR174-likecd151537tmA_P2Y10cd151547tmA_LPAR5cd151557tmA_LPAR4cd151567tmA_LPAR6_P2Y5cd151597tmA_EBI2cd151607tmA_Proton-sensing_Rcd153647tmA_GPR132_G2Acd153657tmA_GPR65_TDAG8cd153667tmA_GPR4cd153677tmA_GPR68_OGR1cd151617tmA_GPR17cd151627tmA_PARcd153687tmA_P2Y8cd153697tmA_PAR1cd153707tmA_PAR2cd153717tmA_PAR3cd153727tmA_PAR4cd151637tmA_GPR20cd151667tmA_NAGly_R_GPR18cd151677tmA_GPR171cd151687tmA_P2Y1-likecd153737tmA_P2Y2cd153747tmA_P2Y4cd153757tmA_OXGR1cd153767tmA_P2Y11cd153777tmA_P2Y1cd153787tmA_SUCNR1_GPR91cd159677tmA_P2Y1-likecd159687tmA_P2Y6_P2Y3-likecd153797tmA_P2Y6cd160017tmA_P2Y3-likecd159207tmA_GPR34-likecd159217tmA_CysLTRcd151577tmA_CysLTR2cd151587tmA_CysLTR1cd159227tmA_P2Y-likecd159237tmA_GPR35_55-likecd151647tmA_GPR35-likecd151657tmA_GPR55-likecd159247tmA_P2Y12-likecd151497tmA_P2Y14cd151507tmA_P2Y12cd151517tmA_P2Y13cd159697tmA_GPR87cd149847tmA_Chemokine_Rcd151727tmA_CCR6cd151737tmA_CXCR6cd151747tmA_CCR9cd151757tmA_CCR7cd151767tmA_ACKR4_CCR11cd151777tmA_CCR10cd151787tmA_CXCR1_2cd151797tmA_CXCR4cd151807tmA_CXCR3cd151817tmA_CXCR5cd151827tmA_XCR1cd151837tmA_CCR1cd151847tmA_CCR5_CCR2cd151857tmA_CCR3cd151867tmA_CX3CR1cd151877tmA_CCR8cd151887tmA_ACKR2_D6cd149857tmA_Angiotensin_R-likecd151897tmA_Bradykinin_Rcd153807tmA_BK-1cd153817tmA_BK-2cd151907tmA_Apelin_Rcd151917tmA_AT2Rcd151927tmA_AT1Rcd151937tmA_GPR25cd151947tmA_GPR15cd149867tmA_Vasopressin-likecd151957tmA_GnRHR-likecd153827tmA_AKHRcd153837tmA_GnRHR_vertebratecd153847tmA_GnRHR_invertebratecd151967tmA_Vasopressin_Oxytocincd153857tmA_V1aRcd153867tmA_V1bRcd153877tmA_OT_Rcd153887tmA_V2Rcd151977tmA_NPSRcd151987tmA_GPR150cd149877tmA_ACKR3_CXCR7cd149887tmA_GPR182cd149897tmA_GPER1cd149907tmA_GPR146cd149927tmA_TACR_familycd152027tmA_TACR-likecd153897tmA_GPR83cd153907tmA_TACRcd160027tmA_NK1Rcd160037tmA_NKR_NK3Rcd160047tmA_SKR_NK2Rcd153927tmA_PR4-likecd153937tmA_leucokinin-likecd152047tmA_prokineticin-Rcd153917tmA_NPR-like_invertebratecd149937tmA_CCKR-likecd152057tmA_QRFPRcd152067tmA_CCK_Rcd159787tmA_CCK-ARcd159797tmA_CCK-BRcd152077tmA_NPFFRcd159807tmA_NPFFR2cd159817tmA_NPFFR1cd152087tmA_OXRcd149957tmA_TRH-Rcd149977tmA_ETH-Rcd149987tmA_GPR153_GPR162-likecd159067tmA_GPR162cd159077tmA_GPR153cd149997tmA_UII-Rcd150007tmA_BNGR-A34-likecd150017tmA_GPRnna14-likecd150027tmA_GPR151cd150057tmA_SREB-likecd152167tmA_SREB1_GPR27cd152177tmA_SREB3_GPR173cd152187tmA_SREB2_GPR85cd150067tmA_GPR176cd150077tmA_GPR75cd150087tmA_GPR19cd150107tmA_ACKR1_DARCcd150117tmA_GPR149cd150127tmA_Trissin_Rcd151047tmA_GPR119_R_insulinotropic_receptorcd151717tmA_CCRL2cd152037tmA_NPYR-likecd153947tmA_PrRP_Rcd153957tmA_NPY1Rcd153967tmA_NPY6Rcd153977tmA_NPY4Rcd153987tmA_NPY5Rcd153997tmA_NPY2Rcd152097tmA_Mel1cd154007tmA_Mel1Bcd154017tmA_Mel1Ccd154027tmA_Mel1Acd152107tmA_GPR84-likecd152117tmA_GPR88-likecd152127tmA_GPR135cd152137tmA_PSP24-likecd154037tmA_GPR45cd154047tmA_GPR63cd152147tmA_GPR161cd152157tmA_GPR101cd152197tmA_GPR26_GPR78-likecd152207tmA_GPR61_GPR62-likecd159057tmA_GPBAR1cd139497tm_V1R_pheromonecd139507tm_TAS2Rcd150137tm_TAS2R4cd150167tm_TAS2R1cd150177tm_TAS2R16cd150187tm_TAS2R41-likecd150197tm_TAS2R14-likecd150207tm_TAS2R3cd150217tm_TAS2R10cd150227tm_TAS2R8cd150237tm_TAS2R7-likecd150247tm_TAS2R42cd150257tm_TAS2R38cd150267tm_TAS2R13cd150277tm_TAS2R43-likecd159087tm_TAS2R40-likecd150147tm_TAS2R40cd150157tm_TAS2R39cd139517tmF_Frizzled_SMOcd150307tmF_SMO_homologcd150317tmF_FZD3_insectcd150347tmF_FZD1_2_7-likecd152457tmF_FZD2cd152467tmF_FZD7cd152477tmF_FZD1cd152487tmF_FZD1_insectcd150357tmF_FZD5_FZD8-likecd152497tmF_FZD5cd152507tmF_FZD8cd159097tmF_FZD4_9_10-likecd150367tmF_FZD9cd150377tmF_FZD10cd150387tmF_FZD4cd159107tmF_FZD3_FZD6-likecd150327tmF_FZD6cd150337tmF_FZD3cd139527tm_classBcd150397tmB3_Methuselah-likecd150407tmB2_Adhesioncd152517tmB2_BAI_Adhesion_VIIcd159887tmB2_BAI2cd159897tmB2_BAI3cd159907tmB2_BAI1cd152527tmB2_Latrophilin_Adhesion_Icd154367tmB2_Latrophilincd160057tmB2_Latrophilin-3cd160067tmB2_Latrophilin-2cd160077tmB2_Latrophilin-1cd154377tmB2_ETLcd154407tmB2_latrophilin-like_invertebratecd152577tmB2_GPR128cd152587tmB2_GPR126-like_Adhesion_VIIIcd154427tmB2_GPR97cd154437tmB2_GPR114cd154447tmB2_GPR64cd159957tmB2_GPR56cd159967tmB2_GPR126cd159977tmB2_GPR112cd152597tmB2_GPR124-like_Adhesion_IIIcd159987tmB2_GPR124cd159997tmB2_GPR125cd160007tmB2_GPR123cd154417tmB2_CELSR_Adhesion_IVcd159917tmB2_CELSR1cd159927tmB2_CELSR2cd159937tmB2_CELSR3cd159317tmB2_EMR_Adhesion_IIcd154387tmB2_CD97cd154397tmB2_EMRcd159327tmB2_GPR116-like_Adhesion_VIcd152537tmB2_GPR113cd152547tmB2_GPR116_Ig-Heptacd159947tmB2_GPR111_115cd159337tmB2_GPR133-like_Adhesion_Vcd152557tmB2_GPR144cd152567tmB2_GPR133cd150417tmB1_hormone_Rcd152607tmB1_NPR_B4_insect-likecd152617tmB1_PDFRcd152627tmB1_NPR_B3_insect-likecd152637tmB1_DH_Rcd152647tmB1_CRF-Rcd154457tmB1_CRF-R1cd154467tmB1_CRF-R2cd152657tmB1_PTHRcd159827tmB1_PTH2Rcd159837tmB1_PTH3Rcd159847tmB1_PTH1Rcd152727tmB1_PTH-R_relatedcd152737tmB1_NPR_B7_insect-likecd152747tmB1_calcitonin_Rcd159297tmB1_GlucagonR-likecd152667tmB1_GLP2Rcd152677tmB1_GCGRcd152687tmB1_GLP1Rcd159857tmB1_GlucagonR-like_1cd159307tmB1_Secretin_R-likecd152697tmB1_VIP-R1cd152707tmB1_GHRHRcd152717tmB1_GHRHR2cd152757tmB1_secretincd159867tmB1_VIP-R2cd159877tmB1_PACAP-R1cd139537tm_classC_mGluR-likecd150427tmC_Bosscd150437tmC_RAIG_GPRC5cd152777tmC_RAIG3_GPRC5Ccd152787tmC_RAIG2_GPRC5Bcd152797tmC_RAIG1_4_GPRC5A_Dcd150447tmC_V2R_AA_sensing_receptor-likecd152807tmC_V2R-likecd152817tmC_GPRC6Acd152827tmC_CaSRcd152837tmC_V2R_pheromonecd150457tmC_mGluRscd152857tmC_mGluR_group1cd154497tmC_mGluR1cd154507tmC_mGluR5cd159347tmC_mGluRs_group2_3cd152847tmC_mGluR_group2cd154477tmC_mGluR2cd154487tmC_mGluR3cd152867tmC_mGluR_group3cd154517tmC_mGluR7cd154527tmC_mGluR4cd154537tmC_mGluR6cd154547tmC_mGluR8cd150467tmC_TAS1Rcd152877tmC_TAS1R2a-likecd152887tmC_TAS1R2cd152897tmC_TAS1R1cd150477tmC_GABA-B-likecd152917tmC_GABA-B-R1cd152927tmC_GPR156cd152937tmC_GPR158-likecd152947tmC_GABA-B-R2cd152907tmC_TAS1R3cd149397tmD_STE2cd149407tmE_cAMP_R_Slime_moldcd149657tm_Opsins_type1cd150287tm_Opsin-1_eukcd150297tm_SRI_SRIIcd152387tm_ARII-likecd152397tm_YRO2_fungal-likecd152407tm_ASR-likecd152417tm_ChRscd152427tm_Proteorhodopsincd152437tm_Halorhodopsincd152447tm_bacteriorhodopsincd210617tm_viral_rhodopsincd210877tm_viral_rhod_II_OLPVRII-likecd210887tm_viral_rhod_I_VirRDTS-likecd149667tmD_STE3cd149787tmA_FMRFamide_R-likecd151297tmA_GPR142cd159197tmA_GPR139
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
BAD72879      57 WALIAGYIVVFIVALVGNVLVCIAVWKNHHMRtvTNYFIVNLSLADILVTITCLPATLVVDItetWFFGhhlCKAIPYLQ 136 chicken
NP_001073337  55 WVLIAGYILVFLVSLVGNTLVCFAVWKNHHMRtvTNYFIVNLSFADILVTITCLPASLVVDItetWFFGqtlCKILPYLQ 134 zebrafish
O43614        55 WVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRtvTNYFIVNLSLADVLVTITCLPATLVVDItetWFFGqslCKVIPYLQ 134 human
O43613        47 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRtvTNYFIVNLSLADVLVTAICLPASLLVDItesWLFGhalCKVIPYLQ 126 human
ADT91713      53 WVLIVGYIIVFIIALIGNILVCVAVWKNHHMRtvTNYFIVNLSLADVLVTIICLPATLLVDItetWFFGktlCKVIPYLQ 132 African clawed ...
ACY92610      54 WVLISAYFLVFILALGGNVLVCYAVLRNPQMRtvTNYYILNLSIADILVSLICLPITVVFETsetWFFGnlaCKLIPYFQ 133 Saccoglossus ko...
NP_001127714  73 WILIATHTFVFITGLFGNALVCVAVYRNHSMRtvTNYFIVNLAVADFMVILFCLPATVLWDVtetWFLGeglCKVLPYFQ 152 domestic silkworm
ELU16138      65 WCLIVLYLIVFTLGLVGNFLVVFVVVRNKHMRtiTNLFIVNLSVADFLVLLICLPASVLTDVtetWFMGrvmCKLVHYLQ 144 Capitella sp. I...
ELU18833      32 WILILLYGMIFVIGLVGNFLVCFAVWRNPSMRtvTNYFIVNLALADFLVILICLPSTVIEDVamtWFFGrimCKIVKYLQ 111 Capitella sp. I...
EKC31663      50 WGIIILYALTFIVGLSGNVLVCFAVWRNRSMRtvTNIFIVNLAIADLAVIIICLPPTLLSDVtetWYFGfamCKIALFLQ 129 Pacific oyster
EKC39941      35 WILIGLFVVVFLLGISGNLLVCLAVWRNRNLRtlTNVHLVNLAVADFMVIAVCLPPTLLHDAlesWFLGtvgCKIVTYLQ 114 Pacific oyster
XP_006007993  91 WALIAGYIIVFIVALFGNILVCVAVWKNHHMRtvTNYFIVNLSLADVLVTITCLPASLVVDItetWFFGqtlCKVIPYLQ 170 coelacanth
XP_007892276  57 WVLIAAYIAVFVVALVGNVLVCVAVWKNHHMRtvTNYFIVNLSFADVLVTIICLPASLVVDItetWFFGqifCKVIPYLQ 136 elephant shark
Feature 1        #  #                                          # #####                           
BAD72879     137 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCIIMIPQAIVMecssvfpglankttlFTVCDehw 216 chicken
NP_001073337 135 TISVSVSVLTLSCIAQDRWYAICHPlkFKSTAkRARKSIVLIWLVSCIMMIPQAVVMessslmpeltnktslFTVCDeqw 214 zebrafish
O43614       135 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIVIIWIVSCIIMIPQAIVMecstvfpglankttlFTVCDerw 214 human
O43613       127 AVSVSVAVLTLSFIALDRWYAICHPllFKSTArRARGSILGIWAVSLAIMVPQAAVMecssvlpelanrtrlFSVCDerw 206 human
ADT91713     133 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRAQQSIVIIWIVSCVIMIPQAIVMecrsvfpelanktilFTVCDerw 212 African clawed ...
ACY92610     134 VVSMSVSVLTLCAIAVDRYFAICHPlmFKSTAkRAITVIFSIWITSFLVPIPQAVVYeterpiy--tknyiyLTKCFern 211 Saccoglossus ko...
NP_001127714 153 SVSVTVSVLTLTFISVDRWYAICFPlkFKSTTgRAKTAILIIWLVSLCFNIPELVVLklvrfvp-lrfelpyLLQCYgtw 231 domestic silkworm
ELU16138     145 AVSVSVSVLTLTVISIERYYAICHPlsFKSTHtRARLMIILVWVISLAIVIPELVILdlfphk----pytdlLMACKpsw 220 Capitella sp. I...
ELU18833     112 AVSVAVSVFTLSCISLERFYAICYPlsFKSTPrRAKVMIVVTWVLALLMAIPDLICLdtqhnsg-lpadfslLTTCKptw 190 Capitella sp. I...
EKC31663     130 TTSVAVSVFTLSAISVERWYAICYPlrFKSTKrRAKIIILVIWIIAFLLALPEVIVAdltrfvk--rqyidlLIFCGpqw 207 Pacific oyster
EKC39941     115 KVSVLVSVLTLTTIGIERYLGICHPmsDFLPRiKTRVALLGIWVVAMVTAIPDAYYMtvipdnv-ipptinlLKSCRpsd 193 Pacific oyster
XP_006007993 171 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCVIMIPQAIVMecsnlvpelanktnlFTVCDeqw 250 coelacanth
XP_007892276 137 TVSVSVSVLTLSCIALDRWYAICHPlmFKSTAkRARNSIIIIWIVSCVLMTPQAIVMecsimvpelvnktilFTVCDehw 216 elephant shark
Feature 1              #  ### ### ##                                                             
BAD72879     217 g-aevyPKMYHTCFFLVTYMAPLCLMVLAYLQIFRKLWcrqipgtssvvqkkwkslqssaq--qrglgqstkskisavaa 293 chicken
NP_001073337 215 p-deiyPKVYHTCFFIVTYFAPLCLMVLAYIQICHKLWcqqipgsssvlqrqwkslqcsah--avgsgesvkvrtstvsa 291 zebrafish
O43614       215 g-geiyPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWcrqipgtssvvqrkwkplqpvsq--prgpgqptksrmsavaa 291 human
O43613       207 a-ddlyPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqprarafla 285 human
ADT91713     213 e-gqiySKVYHICFFFITYMVPLCLMILAYLQIFRKLWcrqipgtssvvqrkwkplqcsi---hskgqqstksrnnavaa 288 African clawed ...
ACY92610     212 wfgsiqQKVYHIALVLVIYVIPLVMIIIAYVFICRQLWakipgsyescdskkna---------------sngnshvstka 276 Saccoglossus ko...
NP_001127714 232 s--pssELVWHILKVLLIYTLPLVLMAVAYHQIARVLWssngipgqadt-------------------------kklata 284 domestic silkworm
ELU16138     221 s--ytsQAAFQIVLIVALFFLPFCLMGFAYIRIALCLWsdfiptescecnkpl-----------------nadgksshhe 281 Capitella sp. I...
ELU18833     191 s--hsiQVGVQCFNLLVMYLLPLGFMFCTYFRIVRCLWsnniptessrdql---------------------hsngsnsa 247 Capitella sp. I...
EKC31663     208 s-dktnQVVYQSVIIVLMYLLPLVLMTVTYSMIAVVLWtgkipgaiesanrp--------------------mmdgnvnr 266 Pacific oyster
EKC39941     194 ---sqvEVTQQLVIFFVFFIIPLAIMGFAYTNIFLCLWrstqslpnin----------------------------neha 242 Pacific oyster
XP_006007993 251 g-deiyPKVYHICFFLVTYMAPLCLMILAYLQIFHKLWcrqipgtssvvqrkwkplqcslq--prgsgfknkpkvnavaa 327 coelacanth
XP_007892276 217 g-dtvyPKVYHICFFIVTYMGPLCLMILAYFQIFRKLWcrqipgtssvvqrkwkplalqcs-sqraaglqtkprinavaa 294 elephant shark
Feature 1                                 #  ## ##  #               ## ###  #  ##                
BAD72879     294 eikqiRARRKTARMLMVVLLVFALCYLPISILNILKrvfgmfn-haddretVYAWFTFSHWLVYANSAANPIIYNFLSgk 372 chicken
NP_001073337 292 eakqvKARRKTARMLMVVLFVFALCYLPISILNIMKrvfgafk-ntgnretVYAWFTFSHWLIYANSAANPIIYNFLSgk 370 zebrafish
O43614       292 eikqiRARRKTARMLMIVLLVFAICYLPISILNVLKrvfgmfa-htedretVYAWFTFSHWLVYANSAANPIIYNFLSgk 370 human
O43613       286 evkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgmfr-qasdreaVYACFTFSHWLVYANSAANPIIYNFLSgk 364 human
ADT91713     289 eikqiHTRRKTARMLMVVLLVFALCYLPISILNILKrvfgmft-htndretVYAWFTFSHWLVYANSAANPIIYNFLSgk 367 African clawed ...
ACY92610     277 sesqlKSRRKVAKMLIIVVVIFTICYLPLHLLNILRqfsffddvvhntrssFHIPFLIAHWLAFANSGVNPIIYNFLSak 356 Saccoglossus ko...
NP_001127714 285 eltqlRSRRKAAKMLVSVVIMFAVCYFPVHLLSVMRytidm-----gqtefITIWALVSHVMCYANSAINPLIYNLMSdk 359 domestic silkworm
ELU16138     282 vrqqvTSRRNVAKMLIAVVIMFGICYLPVHLLNILRyakal-----mngvaAVNFALIAHWLCYFNSAINPLIYNFMSak 356 Capitella sp. I...
ELU18833     248 aenqlRGRRNAAKMLIAVVVMFCICYLPVHLLNILGyanald----ligdyITLLALMSHWLSYLNSAINPVIYNYMSmp 323 Capitella sp. I...
EKC31663     267 aeeqlESRKKAAKMLITVVIGFAVCYFPVHLFNILRyadalr---fvaprmIQVLSMISHWLPYLNSSINPIIYNFMSvq 343 Pacific oyster
EKC39941     243 antviQNRKITAKMLIVVVAAFFACNLPVYILNILRyvgvlf---tvdhakIKSFALSSHLLLYTSSAINPVIYTIMSgh 319 Pacific oyster
XP_006007993 328 eikqiHARRKTARMLMVVLFIFALCYLPISILNILKrvfgmfk-ssndretVYAWFTFSHWLVYANSAANPIIYNFLSgk 406 coelacanth
XP_007892276 295 eikqiRARRKTARMLMVVLFFFAVCYLPISILNVLKrvfgmfd-niddratVYAWFMFSHWLVYANSAANPIIYNFLSgk 373 elephant shark
Feature 1             
BAD72879     373 FREEF 377 chicken
NP_001073337 371 FREEF 375 zebrafish
O43614       371 FREEF 375 human
O43613       365 FREQF 369 human
ADT91713     368 FREEF 372 African clawed frog
ACY92610     357 FRREF 361 Saccoglossus kowalevskii
NP_001127714 360 FRREF 364 domestic silkworm
ELU16138     357 FRKEF 361 Capitella sp. I Grassle & Grassle, 1976
ELU18833     324 IAPSA 328 Capitella sp. I Grassle & Grassle, 1976
EKC31663     344 TKGAF 348 Pacific oyster
EKC39941     320 SQTTD 324 Pacific oyster
XP_006007993 407 FREEF 411 coelacanth
XP_007892276 374 FREEF 378 elephant shark

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
HHS Vulnerability Disclosure