Conserved Protein Domain Family
DEXHc_HFM1
?
cd18023: DEXHc_HFM1 
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1
HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
?
Statistics
?
PSSM-Id: 350781
Aligned: 11 rows
Threshold Bit Score: 316.606
Created: 18-Feb-2014
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Saccharomyces cerevisiae Chd1 with bound gamma-thio-ATP
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         ###  #                   #######                                                
NP_001017975  280 YFNYIQSKAFDDllytDRNFVICAPTGSGKTVVFELAITRLLmevpl-----------------------------pwln 330  human
XP_003195636  192 CFNKVQSEVFGDvyesDENLVVSAPTGSGKTTIFELAFLHNLsfrtpn----------------------------dslk 243  Cryptococcus ...
AEE77357       24 YFNSLQSECFPLcfhsDINMIISAPTGSGKTVLFELCILRLFsksiskegs----------------------flhakga 81   thale cress
A2RUV5        149 YFNYIQSKALEHllysDRNFVLCAPTGSGKTVIFELAIIRLLmqvpm-----------------------------pwtn 199  western clawe...
EAT37001       49 QFNEIQSLVMDDmlytDKSLVVSAPTGSGKTAIFELAMVRLLmkleds---------------------------ryegd 101  yellow fever ...
CBN74377      274 NFNAIQSALFQTaaksDKNVVVSAPTGCGKTVVLEMAIARLWqesgg-----------------------------tlgn 324  Ectocarpus si...
EGD75738      216 SFNRVQSLCFNDlyhsTDNVVISAPTGCGKTACMELAMLQVLkartp------------------------------tdk 265  Salpingoeca s...
XP_009296777  243 YFNYVQSQALDDvlysNKNFVACAPTGSGKTVLFELAIVRLLiease-----------------------------pwhn 293  zebrafish
ABO96376       29 YFNSIQSEMLEFlvntRRSFVMSAPTGSGKTTVFELAMLAALrgpnategg----------------------lsaargr 86   Ostreococcus ...
P51979        138 EFNKMQSEAFPSiyesNENCIISSPTGSGKTVLFELAILRLIketns-----------------------------dtnn 188  Saccharomyces...
EAN80409       64 NFTRVQERVIPAiiqnDFNVVVAAPTGSGKTALLEAAMLRLFkdrltlntvgsdaalppnaddevdaasgnkeyansptn 143  Trypanosoma b...

Feature 1                                                                                         
NP_001017975  331 iKIVYMAPIKALCSQRFDDWKEKfgp--iglNCKELTGDtvmddl------feiqhaHIIMTTPEKWDSMTRkwrdn--- 399  human
XP_003195636  244 pLAVYIAPTKALCNEKAKDWQERlgqalpdvICTEITGDygntsti----ynsirgaDLIVTTPEKFDSMTRrsrnlg-- 317  Cryptococcus ...
AEE77357       82 lKTVYISPSKALVQEKLRDWNQKfns--wgiSCLELTGDnetyst------kniqdaDIILTTPEKFDAVSRyrvtsggl 153  thale cress
A2RUV5        200 vKIVYMAPIKALCGQRYDDWKAKfgp--vglNCKELTGDtemddl------feiqhaHIIMTTPEKWDSMTRkwkdn--- 268  western clawe...
EAT37001      102 yRMIYIAPIKALCAEKFADWKGKfep--lgvKTAEVTGDtemkdf------wdlpdcNLILTTPEKWNSITRrwrqnv-- 171  yellow fever ...
CBN74377      325 rKVIYISPIKALCQQTLDDWTAKfsp--lgiRLAELTSDstsgpskgsvslrdlasaDVILTTPEKWDSITRrwkeha-- 400  Ectocarpus si...
EGD75738      266 aIVIYIAPMKALCDEREQDWKEKlsp--lglCVMKITGDsqledl------rnissaDVVITTPEKWDSMTRrwrdnq-- 335  Salpingoeca s...
XP_009296777  294 vRAVYMAPIKALCSQQYDNWKQKfgp--lglKCKELTGDteiddf------feiqdaHLIFTTAEKWDSMTRrwkdn--- 362  zebrafish
ABO96376       87 rKVIYLAPSRALVSEKAREWRERlgr--igiTFAELTGDndfggdv----wgeienvDAILATPEKFDRVTRldanrggm 160  Ostreococcus ...
P51979        189 tKIIYIAPTKSLCYEMYKNWFPSfv----nlSVGMLTSDtsflet------ekakkcNIIITTPEKWDLLTRrwsdys-- 256  Saccharomyces...
EAN80409      144 rKAVYICPMKALAFEKYTQWRERfp----alSVVMETGDqeamrtvda-imdevfqtDIIITTPERWDGITRrwkegvvw 218  Trypanosoma b...

Feature 1                                                                                         
NP_001017975  400 slvqlVRLFLIDEVHIvkdenRGPTLEVVVSRmktvqsvsqt-lkntstaipMRFVAVSATiPNAEDIAEWLsdge-rpa 477  human
XP_003195636  318 nmsqrLQLIMIDEVHIlr-esRGATLEVVISRlkgl-------------srdIRFIALSATvPNIDDIARWLg------p 377  Cryptococcus ...
AEE77357      154 gffsdIALVLIDEVHLln-dpRGAALEAIVSRlkilssnhe---lrsstlasVRLLAVSATiPNIEDLAEWLkvp---ta 226  thale cress
A2RUV5        269 tlvqlVRLFLIDEVHIlkeenRGATLEVVVSRmktiyslshl-sedrkafipMRFVAVSATiPNVEDIADWLsden-spg 346  western clawe...
EAT37001      172 nfvrmIRLVMIDEVHIlndqfRGPVLEAVVSRmrsihrfvegdggesavvdpMRIIALSATaPNVADLAAWVgea--ntt 249  yellow fever ...
CBN74377      401 flvgtVALVLVDEVHTig-eeRGATLEVILARmkmvsrstev-vsmglpasrMRFIALSATlPNANDFGSFLg------a 472  Ectocarpus si...
EGD75738      336 alarhVRLLLIDEVHVigeanRGHTLEVVATRmktmamg-------tkdhpgIRIVAVSATvPNLNDVAKWLrtnerkpa 408  Salpingoeca s...
XP_009296777  363 clltsIRLFLVDEVHVvkdktRGATLEVVVSRmktmhfyrq--ainpeskasVRFVAVSATiPNIQDVSEWLsdes-gpa 439  zebrafish
ABO96376      161 sffsdVAAVLIDEVHLig-diRGGCLEAIVSRlkllskssa---llqshlrnVRFGAVSATiPNIENLANWLgan---rd 233  Ostreococcus ...
P51979        257 rlfelVKLVLVDEIHTik-ekRGASLEVILTRmntm-------------cqnIRFVALSATvPNIEDLALWLktnnelpa 322  Saccharomyces...
EAN80409      219 nlvasVALLMLDEVHTvs-eeRGAALEAVVSRmkaiklsmt---trgpqvcrTRFVAISGTlPNIEDFAEWLqvp---pa 291  Trypanosoma b...

Feature 1                    
NP_001017975  478 VCLKMDESHRP 488  human
XP_003195636  378 TRNEYGQLSRG 388  Cryptococcus bacillisporus WM276
AEE77357      227 GIKRFGEEMRP 237  thale cress
A2RUV5        347 VCMKMDESSRP 357  western clawed frog
EAT37001      250 CFYNISESRRP 260  yellow fever mosquito
CBN74377      473 EVFRFGDEFRP 483  Ectocarpus siliculosus
EGD75738      409 RAHLFGPEFRP 419  Salpingoeca sp. ATCC50818
XP_009296777  440 TCLEMDESHRP 450  zebrafish
ABO96376      234 GTFVFGEEFRP 244  Ostreococcus lucimarinus CCE9901
P51979        323 NILSFDESYRQ 333  Saccharomyces cerevisiae S288c
EAN80409      292 GVFSFTSADRP 302  Trypanosoma brucei

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap