2ATV,3C5C


Conserved Protein Domain Family
RERG_RasL11_like

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cd04146: RERG_RasL11_like 
Click on image for an interactive view with Cn3D
Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
RERG (Ras-related and Estrogen- Regulated Growth inhibitor) and Ras-like 11 are members of a novel subfamily of Ras that were identified based on their behavior in breast and prostate tumors, respectively. RERG expression was decreased or lost in a significant fraction of primary human breast tumors that lack estrogen receptor and are correlated with poor clinical prognosis. Elevated RERG expression correlated with favorable patient outcome in a breast tumor subtype that is positive for estrogen receptor expression. In contrast to most Ras proteins, RERG overexpression inhibited the growth of breast tumor cells in vitro and in vivo. RasL11 was found to be ubiquitously expressed in human tissue, but down-regulated in prostate tumors. Both RERG and RasL11 lack the C-terminal CaaX prenylation motif, where a = an aliphatic amino acid and X = any amino acid, and are localized primarily in the cytoplasm. Both are believed to have tumor suppressor activity.
Statistics
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PSSM-Id: 206713
Aligned: 17 rows
Threshold Bit Score: 226.775
Created: 6-Dec-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:2ATV: Human Rerg binds GDP and Mg2+, defined using 3.5 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ######            #                                                     
2ATV_A     30 KLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLeSTYRHQATIDdEVVSMEILDTAGqe----dtIQREGHMRWGEGFVLV 105 human
AAH76311    5 KVAVLGSEGVGKSALIVRFLTRRFIGEYASSSeCIYRKRMSIDaRQLNLELHDPCSqpc--dgkSTLNEQIHWADGFVVV 82  zebrafish
NP_057647  22 NLAILGRRGAGKSALTVKFLTKRFISEYDPNLeDTYSSEETVDhQPVHLRVMDTADld----tpRNCERYLNWAHAFLVV 97  human
AAH54128   25 NIVILGAMGSGKSALTVKFLTKRFISEYDPNLeDTYSSEEVVDqQPVLVKVMDTADqe----gpVNGERYLGWANAFIIV 100 zebrafish
AAH74392    8 KIAIFGRAGVGKSALVVRFLTKRFIWEYDPTLeSTYRHQATIDdDLVTMELLDTAGqe----diIQREGHARWADGFAIV 83  African clawed frog
CAI11772    5 KLALLGSEGAGKSAVLVRFLTKRFIGEYASNAnSLYHKRLSIDgRQLNLEVFDPCSqsg--esrCILEEPVDWADGFVVV 82  zebrafish
AAH42888    6 HLKYNEKSVSVTKALTVRFLTKRFIGEYASNFeSIYKKHLCLErKQLNLEIYDPCSqtq--kakFSLTSELHWADGFVIV 83  human
AAH95376   12 KLVVLGRDNCGKTALCVRFITRRFIGEYEHKReVNYRCQKIVDkEAIELEILDTVNkdcvgaaaSSLESSIKWGDGFLIM 91  zebrafish
AAF52508   24 KVMVLGQSGVGKTAMVVRFITRRFIGEYDPNLeKIYTCQTTLDkEQIQFDILDATGqlqe-ldgVSLESNIRWADAFILM 102 fruit fly
AAH73716   14 NILVLGAENVGKSALTVRFLTRRFIGEYVGTE-SIYTHNVTVDgRETSFSIWDSVCpqnpnaqnCITEDQLRWADGFILV 92  African clawed frog
Feature 1                                                  ## #                           ### 
2ATV_A    106 YDITDRGSFEEVLPLKNILDEikk-----------pkNVTLILVGNKADLDhsRQVSTEEGEKLATELa-cAFYECSACT 173 human
AAH76311   83 YDISDRSSFLTAKAIVHLIRElhlga------tkrdsDSVIFLVGNKQDLChmREVDREEGQKLASESr-cQFYELSAAE 155 zebrafish
NP_057647  98 YSVDSRQSFDSSSSYLELLALhake---------tqrSIPALLLGNKLDMAqyRQVTKAEGVALAGRFg-cLFFEVSACL 167 human
AAH54128  101 YSIDNRSSFEVCQQYLETVSLyskg---------lqpEAPVILLGNKVDMEryRQVSKADGAALALRFg-cLFFEVSACL 170 zebrafish
AAH74392   84 YDITDKGSFDEVLPFKNLLDEikk-----------pkNVTFILVGNKADLDhsRQVSTEEGEKLATELa-cAFYECSACT 151 African clawed frog
CAI11772   83 YTISDRTSFLNAKNILAQIKEsrre--------tckgEVPVCLVGNKQDLChsRQVSEEEGRVLSQEYk-cLFQEVSAAE 153 zebrafish
AAH42888   84 YDISDRSSFAFAKALIYRIREpqtsh------ckravESAVFLVGNKRDLChvREVGWEEGQKLALENr-cQFCELSAAE 156 human
AAH95376   92 YSVTDRSSFEAVSRLKRLIDHvkq-----------tlGIPTVVVANKCDMEngRVVRTDEGQALASDLr-cSFFELSVAE 159 zebrafish
AAF52508  103 YSITDKCSFDECSRLKFLINYnkrrrklgsaskeyalDIPVILVGNKTDQPgdRMVSLEEGQRRFRELscsCFHEISVRE 182 fruit fly
AAH73716   93 YSICERDSFSVVRQQLHRIRQmkk----------rhgPVPVIIVGNKRDLQhhREITSEEGRMLALSSd-cGFFEISAAE 161 African clawed frog
Feature 1                       
2ATV_A    174 gEGNITEIFYELCREVRR 191 human
AAH76311  156 hYQEVLLMFSKIVRNASL 173 zebrafish
NP_057647 168 dFEHVQHVFHEAVREARR 185 human
AAH54128  171 dFLSVQHIFHEAVREVRR 188 zebrafish
AAH74392  152 gEGNISEAFYDLCREVRR 169 African clawed frog
CAI11772  154 nYLEISNLFTKLIRHVME 171 zebrafish
AAH42888  157 qSLEVEMMFIRIIKDILI 174 human
AAH95376  160 dASSVEAAFGQLVREVRQ 177 zebrafish
AAF52508  183 sVDQVQNVFRDVFRFWRV 200 fruit fly
AAH73716  162 tYHGSLVVFHQLLEAVRE 179 African clawed frog

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