Conserved Protein Domain Family
ACSBG_like

?
cd05933: ACSBG_like 
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Statistics
?
PSSM-Id: 341256
Aligned: 10 rows
Threshold Bit Score: 973.372
Created: 2-Nov-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q7ZYC4       130 KQGDQWHKMSYKQYYEQCRIAAKGFIKLGLERYHGVGILGFNSAEWFIADVGAIfAGGFAVGIYTTNSAEACHYVAQNCE 209 African clawed ...
EDQ85947      57 KRDGYWHTWTYRDYHRDIITAAKAFIHFGLDRHHSVGIIGFNSPEWFIADLGAVfAGGFASGIYTTNGPESLQYVADHSR 136 Monosiga brevic...
Q5FVE4        73 KNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAIlAGGLCVGIYATNSAEVCQYVITHAK 152 human
Q9V3S9        69 NGKNGYHTVTYKQYEQKVHQVAKAFIKLGLEEHHSVGVLAFNCAEWFYSAMGAIhARGIIAGIYTTNSADAVQHVLESSH 148 fruit fly
Q96GR2       125 KRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVfAGGIVTGIYTTSSPEACQYIAYDCC 204 human
Q5ZKR7       123 KKNGQWVKLTYKMYYDKCWKAAKSFLKLVLERFHGVCILGFNSPEWFIADIGAIfAGGLAVGIYTTNSPEACHYVAENCS 202 chicken
EDL38211     105 KYKKSWQLLTYIEYYEACRRAAKAFLKVGLERFHGVGIMGINSSEWVIASIGAImAGGISVGILSSISPKACQVIAETSE 184 house mouse
Q9V3U0        62 SGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALrAGAVVAGVYPSNSAEAVHHVLATGE 141 fruit fly
XP_001344904  78 KRGNKWEKATFLEYYHLCRMAAKGFLKLGLEQFHGVAILGFNSAEWFIAAVGTVfAGGIMAGIYTTNSPDACLHVANDSR 157 zebrafish
NP_001119851 139 KEGEQWKTMTYSEYYKSCRTAAKSFLKLGLERYHGVGILGFNSTEWFIADIAAIlAGGFAVGIYTTNSPEACQYVAENCQ 218 zebrafish
Feature 1                                                                                        
Q7ZYC4       210 ANIIVVENQKQLQKIl-qVQDQLPHLKAIIQYkdelke-----krpnlYTWKEFMQLGKDipdsql-dqiissQKPNQCC 282 African clawed ...
EDQ85947     137 SQFLFVEDRKQLAKIk-eVQDQLPTVKLVVMWgepveekdrkdlkikvIGWDEFMRGGRDvaehev-hnrmkvQSPGECC 214 Monosiga brevic...
Q5FVE4       153 VNILLVENDQQLQKIlsiPQSSLEPLKAIIQYrlpmk------knnnlYSWDDFMELGRSipdtql-eqviesQKANQCA 225 human
Q9V3S9       149 AQIVVVDDAKQMDKIh-aIRDKLPKLKAAIQIqepyspy--lkkedgyYRWSEIESMNVSdvedqy-mtrlenVAINECC 224 fruit fly
Q96GR2       205 ANVIMVDTQKQLEKIl-kIWKQLPHLKAVVIYkepppn-----kmanvYTMEEFMELGNEvpeeal-daiidtQQPNQCC 277 human
Q5ZKR7       203 ANILVVENHTQACRKsleIEHKLPHMKAIIQYgeelke-----krpnqYSWREFLDLGEDipdsql-reiiesQKPNQCC 276 chicken
EDL38211     185 MDIFVVDNDRQLQKIn-qIQGYLKHLKAIIQYrediqe-----aqpnlYSWKGFLDLADGisdekl-dkiidtLKPNQCC 257 house mouse
Q9V3U0       142 SSVCVVDDAQQMAKLr-aIKERLPRLKAVIQLhgpfeaf--vdhepgyFSWQKLQEQTFSselkeellaresrIRANECA 218 fruit fly
XP_001344904 158 ANVIVVENQKQLDKIm-qVKDKLPHLKAIVQYsgslke-----klanlYSWEEFMELGLEvsdhel-deviskQRANQCC 230 zebrafish
NP_001119851 219 ANILVVENHKQLQKIl-qIQDKLPHLKAIIQYkdelke-----kkpnlYTWAEFMELGRDepdtql-ddiissQKPNQCC 291 zebrafish
Feature 1            #                                           ##                              
Q7ZYC4       283 TLIYTSGTTGQPKGVMLSHDNITWTAAAAGKTvrlreatdlQEIVVSYLPLSHIAAQMIDIWLTMKYGGATYFAQPDALK 362 African clawed ...
EDQ85947     215 TLIYTSGTTGTPKAVMMTHDNITWTAKALSTHarld--dhrQEHIISYLPLSHIAAQILDMHAPILMGAKVWFAQPDALK 292 Monosiga brevic...
Q5FVE4       226 VLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDfkl---tdkHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 human
Q9V3S9       225 CLVYTSGTVGMPKGVMLSHDNITFDVRGIVKAmdrv--vvgAESIVSYLPLSHVAAQTVDIYTCAFVAGCIWFADKDALK 302 fruit fly
Q96GR2       278 VLVYTSGTTGNPKGVMLSQDNITWTARYGSQAgdirpaevqQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALK 357 human
Q5ZKR7       277 TLIYTSGTTGQPKGVMLSHDNLTWTSIAAGRSlmlleatekQELVVSYLPLSHVAAQMIDIWLPVTFGGQVFFAQPDALK 356 chicken
EDL38211     258 ALVYNQGTTGPSKAIMLSHDNITWTTAAIVQSlgfkcppqgQEILVSYLPLCFPGIQILDVWVAISVAGTVYFPSLDSGK 337 house mouse
Q9V3U0       219 MLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHmqdi--qvgKESFVSYLPLSHVAAQIFDVFLGLSHAGCVTFADKDALK 296 fruit fly
XP_001344904 231 VLIYTSGTTGSPKGVMLSHDNITWTAHHASRAgdmqpaeirQESLVSYLPLSHIAAQIYDLWTGIKWGEQISFAQPDALK 310 zebrafish
NP_001119851 292 TLIYTSGTTGQPKGVMLSHDNLTWTAVATSQHvslndadklQEVVVSYLPLSHIAAQMIDIWLPMKAGGVTYFAQPDALK 371 zebrafish
Feature 1                                   # ##  #                      ##                      
Q7ZYC4       363 GS----------LAITLREVRPTAFMGVPRVWEKMQEKMkavgaKSSTIKRKMATWAKGVGLETNLKKMNGStphpmk-- 430 African clawed ...
EDQ85947     293 GS----------LPTTLAEVRPTIFLGVPRVWEKIEEKMrivgaQSTGLKKKIATWAKRKGMEASMADQRGErrpsgf-- 360 Monosiga brevic...
Q5FVE4       303 GT----------LVSTLKEVKPTVFIGVPQIWEKIHEMVkknsaKSMGLKKKAFVWARNIGFKVNSKKMLGKyntpvs-- 370 human
Q9V3S9       303 GT----------LVKSLQDARPTRFMGVPRVYEKFQERMvavasSSGSLKKMLASWAKGITLKHYMVSQGKSsggfry-- 370 fruit fly
Q96GR2       358 GS----------LVNTLREVEPTSHMGVPRVWEKIMERIqevaaQSGFIRRKMLLWAMSVTLEQNLTCPGSDlkpftt-- 425 human
Q5ZKR7       357 GT----------LVDTLREVRPTAFLGVPRVWEKIEEKMksvgaKSSTLRRKVASWAKGVGLQTNLKWMNGHsevpmn-- 424 chicken
EDL38211     338 WSglprtpgtgfLMELLREVQPTTFCGIPWVWDRMLDSLktkflDSTAFRRRIDHWAMRMGLHTNKKLMMGEihqplc-- 415 house mouse
Q9V3U0       297 GT----------LIKTFRKARPTKMFGVPRVFEKLQERLvaaeaKARPYSRLLLARARAAVAEHQTTLMAGKspsiygna 366 fruit fly
XP_001344904 311 GT----------LVDSLREVTPTAHMGVPRVWEKIMEKIkegisRCGYMKRKMVTWAMSVSLDANQRLKKDEeksflf-- 378 zebrafish
NP_001119851 372 GS----------LANTLREIRPTAFLGVPRVWEKMQEKMksigaKSSTVRRKVASWAKDVGLQTNLNKMELGsnsrkpln 441 zebrafish
Feature 1                                                       ######                           
Q7ZYC4       431 yhvankLVFKKVRKALGLDRCTKCYTGAAPITKDTLEFFLSLNIPVYELYGMSESSGPHTISLPDAfRITSCGKVISGCK 510 African clawed ...
EDQ85947     361 -glankLVFKKIRAKLGLDRCHFLATAAAPISRETLDYFLSLYLPIMEVYGMSENTGPQTVNRSGNhTTGSVGVTMAGLE 439 Monosiga brevic...
Q5FVE4       371 yrmaktLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNyRLLSCGKILTGCK 450 human
Q9V3S9       371 -kiaksLIMSKVKQALGFDRVLTLASAAAPMSPETKKYFLSLDLKIVDAFGMSETAGCHTICLPDSvGLNTIGKTLPGCE 449 fruit fly
Q96GR2       426 -rladyLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNyRLYSSGKLVPGCR 504 human
Q5ZKR7       425 frlarqLVYKKVRKAIGLDRCTKCFTGAAPISRETLEFFLSLNIPVFELYGMSESSGPHTVSIPQAfRLTSCGKEMAGCR 504 chicken
EDL38211     416 fglakrLTFERARKFLGLNHCQQFLNMGMGLPSGTLDFFLSVNIPIMELYGLSECTGLHTVSNLQAyRILSAGKALPKTH 495 house mouse
Q9V3U0       367 kywlacRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMSETSGAITLNVDIS-NLYSAGQACEGVT 445 fruit fly
XP_001344904 379 -tlaekLILQKLRAELGFSSCVKFFSGAAPIGRETLQFFLGLNIRLYEAYGMSETSGPHFMSGPEAyQFLSCGKVVPGCQ 457 zebrafish
NP_001119851 442 yrlakhLVFRKVRKALGLDRCTRCYTGAAPITKDTLEFFLSLDIPLFELYGMSESSGPHTITQANAfRLTSCGKVIPGCK 521 zebrafish
Feature 1                                                     #           #  #        ####       
Q7ZYC4       511 TKIHQPDsdgSGEILFWGRHVFMGYLNMEDKTHESLDeEGWLHSGDIGKHDeNGFLYITGRIKELIITAGGENIPPVPTE 590 African clawed ...
EDQ85947     440 TKIDNPDangDGEICMRGRHVMKGYLFNEEKTRETIDeDGWLHTGDVGRMDdRGFLFITGRIKEIIITAGGENVAPVPIE 519 Monosiga brevic...
Q5FVE4       451 NMLFQQNkdgIGEICLWGRHIFMGYLESETETTEAIDdEGWLHSGDLGQLDgLGFLYVTGHIKEILITAGGENVPPIPVE 530 human
Q9V3S9       450 SKFINKDangHGELCIRGRHVFMGYIDNKEKTEESLDdDCWLHSGDLGFVDdKGYVSLTGRSKEIIITAGGENIPPVHIE 529 fruit fly
Q96GR2       505 VKLVNQDaegIGEICLWGRTIFMGYLNMEDKTCEAIDeEGWLHTGDAGRLDaDGFLYITGRLKELIITAGGENVPPVPIE 584 human
Q5ZKR7       505 TLIHKPDadgIGEICFAGRHIFMGYLNMEEKTKEAIDkDGWLHSGDLGKCDkDGFIYITGRIKELIITAGGENVPPVPIE 584 chicken
EDL38211     496 TKVEKENkdgIGNLCIWGRHIFMGYLRDKQSTERKVDtHGWLHTNDLGFLDfDKFLYVMGNNNDLIKLSSGEMVNPYPIE 575 house mouse
Q9V3U0       446 LKIHEPDcngQGEILMRGRLVFMGYLGLPDKTEETVKeDGWLHSGDLGYIDpKGNLIISGRLKELIITAGGENIPPVHIE 525 fruit fly
XP_001344904 458 YKLININadgSGEVCFWGRNVFMGFLNLEDKTKEALDeDGWLRSGDLGKVDeDGFIYINGRIKELIITAGGENIPPLPIE 537 zebrafish
NP_001119851 522 TKLSNPDdekNGEICFWGRHVFMGYLNMPDKTEEALDaEGWLHSGDLGKLDeNNFLFITGRIKELIITAGGENIPPVPIE 601 zebrafish
Feature 1                                                                                        
Q7ZYC4       591 DAVKEQVPIISNAMLIGDKKKFLSMLLTLKCNVNaDTGEPEDELtpeaiqf-crqigskATLVSDIVGGKDt-------- 661 African clawed ...
EDQ85947     520 DTMKACCPILSNVMVIGDKRKFLSQVVTLKCEVDvESGEPLDKLtdqvie---ilssigSSATTVSAAREDp-------- 588 Monosiga brevic...
Q5FVE4       531 TLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNqMSGEPLDKLnfeainf-crglgsqASTVTEIVKQQDp-------- 601 human
Q9V3S9       530 NTIKKELDAISNAFLVGEQRKYLTVLITLKTEVDkDSGEPLDELshessvwvkslgvehKTVSDILAAGPCp-------- 601 fruit fly
Q96GR2       585 EAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDpDTSDQTDNLteqamef-cqrvgsrATTVSEIIEKKDe-------- 655 human
Q5ZKR7       585 DAVKEACPIISNAMLVGDKAKFLAMLLTLKCIINtESGEPGDDLtaeaiey-cqklgskATKVSEIISSKDk-------- 655 chicken
EDL38211     576 ERVRTRIPIVRYAMLVGQDAPYLCALLTLKCQINpETGEARSNLtsevvac-crklrsqSTWLSDVLYDRDp-------- 646 house mouse
Q9V3U0       526 ELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDaKTGIPLDALreetiew-lrdldihETRLSELLNIPAdlqlpndta 604 fruit fly
XP_001344904 538 DAVKQELSIISNAMLIGDERKFLSMLLTLKCTVNpETTEPTDILsleavef-cqrigsqSTKLSDITGGKDk-------- 608 zebrafish
NP_001119851 602 DAVKEAIPLISNAMLIGDKRKFLSMLLTVKCQINgETGVPEDELtpeavef-crklgssCTRVTEIAGGRDr-------- 672 zebrafish
Feature 1                                        #                                           
Q7ZYC4       662 ------------AVYAAIQEGVNSVNEKSTSNAQKVQKWLILEKDFSITGGELGPTMKLKRPVVAKMYKDQIDSFY 725 African clawed frog
EDQ85947     589 ------------KVIEYIDAKRKEANNKSVSRAQNVQKSYILPVDFSVPGGELGPTLKLKRPVVYEKYKDVIDGLY 652 Monosiga brevicolli...
Q5FVE4       602 ------------LVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 human
Q9V3S9       602 ------------KVWKSIEDAIKRANKQSISNAQKVQKFTILPHDFSIPTGELGPTLKVKRNVVSKMYADEIEKLY 665 fruit fly
Q96GR2       656 ------------AVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFY 719 human
Q5ZKR7       656 ------------AVYAAIQAAVSEVNKRAVSNAQKIQKWVVLEKDFSVGGGELGPTMKLKRPVVAQKYKDLIDEFY 719 chicken
EDL38211     647 ------------LVTEFINQGIEDVNSEAPTMGAKIIKWVILDNDFSVDGGELGPMSKMNRSIVVKIYQEEIQKLY 710 house mouse
Q9V3U0       605 alaatleitakpKLLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLY 680 fruit fly
XP_001344904 609 ------------LVYKSIEDGIGQVNSKATSNAQRIQKWTILDKDFSVAGGELGPTMKLRRPVVLQMYHNEIENFY 672 zebrafish
NP_001119851 673 ------------AVQAAIQDGINRVNEKATSNAQRIQKWTVLDQDFSIPGGELGPTMKLKRPVVMKMYKEQIESFY 736 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap