2A8B,1JLN


Conserved Protein Domain Family
R-PTPc-R
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cd14611: R-PTPc-R 
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catalytic domain of receptor-type tyrosine-protein phosphatase R
Receptor-type tyrosine-protein phosphatase-like R (PTPRR or R-PTP-R), also called protein-tyrosine phosphatase PCPTP1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRR is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. The human and mouse PTPRR gene produces multiple neuronal protein isoforms of varying sizes (in human, PTPPBS-alpha, beta, gamma and delta). All isoforms contain the KIM motif and the catalytic PTP domain. PTPRR-deficient mice show significant defects in fine motor coordination and balance skills that are reminiscent of a mild ataxia.
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Statistics
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PSSM-Id: 350459
Aligned: 7 rows
Threshold Bit Score: 488.274
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 15 residue positions
Conserved feature residue pattern:x x x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human PTPN7/HePTP with bound monophosphorylated peptide substrate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #####                                                                        
2A8B_A        45 TKNRYKTILPNPLSRVCLRPKNvtds-lstYINANYIRGYsgkeKAFIATQGPMintvdDFWQMVWQEDsPVIVMITKLk 123 human
1JLN_A        58 TKNRYKTILPNPLSRVCLRPKNitds-lstYINANYIRGYsgkeKAFIATQGPMintvnDFWQMVWQEDsPVIVMITKLk 136 house mouse
AAH93558     207 TKNRYKTILPNPVSRVCLKTKNanda-lssYINANYIRGYgggeKAFIATQGPMintvnDFWQMVWQEDvPVIVMITKLk 285 African clawed ...
XP_001235188 450 TKNRYKTILPNPLSRVYLKPKNpsds-lstYINANYIRGYggkeKAFIATQGPMintvnDFWQMVWQEDsPVIVMITKLk 528 chicken
XP_021330980 399 SKNRYKTILPNPHSRVILKTKNsndp-lssYINANYIRGYlgveRAFIATQGPMintvnDFWQMVWQEDcPVIVMITKLk 477 zebrafish
XP_014342698  81 TKNRYKTILPNPHSRVFLKPKNssdf-lstYINANYIKGYggkeKAFIATQGPMintvnDFWLMVWQEEsPIIVMITKLk 159 coelacanth
XP_007901946 302 TKNRYKTILPNPHSRVCLKPKSsdeslsstYINANYIRGYggekKVHIATQGPMintvnDFWQMVWQEDsPAIVMITKLk 381 elephant shark

Feature 1                                                                  ##                    
2A8B_A       124 ekNEKCVLYWPEKRGiygkVEVLVISVNECdnYTIRNLVLKqgshTQHVKHYWYTSWPDHKTPdsAQPLLQLMLDVEEDR 203 human
1JLN_A       137 ekNEKCVLYWPEKRGiygkVEVLVTGVTECdnYTIRNLVLKqgshTQHVKHYWYTSWPDHKTPdsAQPLLQLMLDVEEDR 216 house mouse
AAH93558     286 ekNEKCVLYWPEKRGiyggVEVLVNSVKECdyYTIRNLTLKqgsqSRTVKHYWYTSWPDHKTPdsAQPLLQLMLDVQEDK 365 African clawed ...
XP_001235188 529 ekNEKCVLYWPEKRGiygkVEVLVNSVQECenYTVRQLTIKqgsqSRSVKHYWYTSWPDHKTPdsAQPLLQLMLDVEEDR 608 chicken
XP_021330980 478 ekNEKCVLYWPEKRGiygkVEVSVNNVKECdhYIIRTLNLKnggqSRKVQHYWYTSWPDHKTPesAGPLLQLVNDVEEDR 557 zebrafish
XP_014342698 160 ekNEKCVLYWPEKRGiygkVEVRVNSVTDCdyYTIRNLTLKhgsqSRSMKHYWYTSWPDHKTPssAQPLLQLMLDVEEER 239 coelacanth
XP_007901946 382 ekNEKCVLYWPEKRGiygrVEVLVNCVDEWehCTVRDLTLKhggkCQSVKHYWYKSWPDHKTPdsAQPLLQLMLDVEETR 461 elephant shark

Feature 1                    #######                                     #          
2A8B_A       204 lasqgrGPVVVHCSAGIGRTGCFIATSIGCQQLkeEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHH 270 human
1JLN_A       217 lasegrGPVVVHCSAGIGRTGCFIATSIGCQQLkeEGVVDALSIVCQLRVDRGGMVQTSEQYEFVHH 283 house mouse
AAH93558     366 knflgrGPVVVHCSAGIGRTGCFISTSIGCCQLkeKGVVDVLNIVCQLRMDRGGMVQTSEQYQFVHH 432 African clawed frog
XP_001235188 609 leaparGPIVVHCSAGIGRTGCFIATAIGCQQLkeEGVVDALSIVCQLRVDRGGMVQTSEQYEFVHH 675 chicken
XP_021330980 558 kgwtssGPVVVHCSAGIGRTGCFMATTIGCRQLglEGLVDVLGIVCQLRTDRGGMIQTEEQYEFVHH 624 zebrafish
XP_014342698 240 lasatkGPVIVHCSAGIGRTGCFIATTIGCHQLknEGLVDVLNIVCQLRVDRGGMIQTSEQYEFVHH 306 coelacanth
XP_007901946 462 qkspgrGPVVVHCSAGIGRTGCFIATTIGCHQLkkEGLVDILSIVCQLRVDRGGMIQTSQQYGFVHH 528 elephant shark

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