Conserved Protein Domain Family
PDI_a_ERp46
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cd03005: PDI_a_ERp46 
PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in vivo. It has been detected in many tissues, however, transcript and protein levels do not correlate in all tissues, suggesting regulation at a posttranscriptional level. An identical protein, named endoPDI, has been identified as an endothelial PDI that is highly expressed in the endothelium of tumors and hypoxic lesions. It has a protective effect on cells exposed to hypoxia.
Links
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Statistics
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PSSM-Id: 239303
Aligned: 17 rows
Threshold Bit Score: 172.854
Created: 15-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:CXXC motif
  • Comment:based on known function of the redox active TRX domains of PDI
  • Comment:Studies on PDI show that a conserved arginine affects the pKa value of the active site cysteine and is critical in reoxidation function.
  • Citation:PMID 8639681
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #  #                                                
Q8NBS9    190 GLYELSAs-NFELHVAQGdHFIKFFAPWCGHCKALAPTWEQLALGleh--seTVKIGKVDCTQHy--ELCSGNQVRGYPT 264 human
AAK93133   38 FTVELDPe-TFDTAIAGGnVFVKFFAPWCGHCKRIQPLWEQLAEImnv-dnpKVIIAKVDCTKHq--GLCATHQVTGYPT 113 fruit fly
AAK93133  303 TPQQLTGedEFDQAIAEGvAFIKFYAPWCGHCQKLQPTWEQLATEthq-aqsSVKIAKVDCTAPenkQVCIDQQVEGYPT 381 fruit fly
AAH45245   31 HKKNLYSadMFDHAVKQEpHFIMFFAPWCGHCQRLQSTWNELGDKyntmpntPAYIAKVDCTTDm--PTCTNHGVRGYPT 108 African clawed frog
Q8NBS9    323 TVLALTEn-NFDDTIAEGiTFIKFYAPWCGHCKTLAPTWEELSKKefp-glaGVKIAEVDCTAEr--NICSKYSVRGYPT 398 human
Q8NBS9     61 HSKHLYTadMFTHGIQSAaHFVMFFAPWCGHCQRLQPTWNDLGDKynsmedaKVYVAKVDCTAHs--DVCSAQGVRGYPT 138 human
AAH57499  218 NVLVLTEs-NFDETVAKGlSFIKFYAPWCGHCKNLAPTWDDLSQKefp-gltDVKIAKVDCTVEr--TLCNRFSVRGYPT 293 zebrafish
CAG32416  305 AVLSLSEk-DFDETIARGiTFIKFYAPWCGHCKNLAPTWEILAKEqfp-gltDVKIAEVDCTVEr--NVCNRFSVRGYPT 380 chicken
XP_392102 262 AVLSLTGe-SFKHGIENGiSFVKFFAPWCGHCKRLAPIWKDLGKKflt--nkNVKIVKVDCTLDiskELCNEQEVDGFPT 338 honey bee
XP_392102  13 YSVQYTKd-NFSIEIQKKnHLVMFYAPWCGHCQRLEPIWEQIAKMsyn-edsNVKIAKVDCTTDs--NLCAEHDVTGYPT 88  honey bee

Feature 1                      #         
Q8NBS9    265 LLWFRDGK-KVDQYKGKRDLESLREYV 290 human
AAK93133  114 LRLFKLGEeESVKFKGTRDLPAITDFI 140 fruit fly
AAK93133  382 LFLYKNGQ-RQNEYEGSRSLPELQAYL 407 fruit fly
AAH45245  109 LKLFKPGQ-EAVKYQGPRDLQSLENWM 134 African clawed frog
Q8NBS9    399 LLLFRGGK-KVSEHSGGRDLDSLHRFV 424 human
Q8NBS9    139 LKLFKPGQ-EAVKYQGPRDFQTLENWM 164 human
AAH57499  294 LLMFRAGQ-QGEEHNGGRDLESLHSFI 319 zebrafish
CAG32416  381 LLLFRGGK-KVSEHNGTRDLESLHSFV 406 chicken
XP_392102 339 LYLYRDGL-KVSEYNGARNLDDLYEFI 364 honey bee
XP_392102  89 LKFFKAGEtKGIKFKGTRDLISLISFL 115 honey bee

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