Conserved Protein Domain Family
GTSE1_N
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pfam15259: GTSE1_N (this model, PSSM-Id:405856 is obsolete and has been replaced by 464599)
G-2 and S-phase expressed 1
This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.
Links
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Statistics
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PSSM-Id: 405856
Aligned: 29 rows
Threshold Bit Score: 105.47
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005988504    6 VTFITEEEFDFGFSFSN-SWEDecdetEDEIFVGPVKHLERCVAKSIDIN--IGNNESQRNNECLTNWSPPTADKLEEIT 82  coelacanth
XP_005163070    9 FVSLAEEKFDFDVSLSPgSSKGdy-evEDEVFVGPVSHKEKCISHGV-EThmKDNISSGPSLGEEPSWSPLTGEKFDEIC 86  zebrafish
9_pfamImport    1 VFFLIDEKFDFDVSLSPaSSNGd----EDEVFVGPVGHAERCVSANV--------ASLASGGGVRTSWSPLNGEQLDAMC 68 
XP_005454253    9 VFFLPDEKFDFDVSLSPaSSRGde--dEDEVFVGPVSHKEKCISVSV--------ASPLENHSI--TWSPLTGEQLEAVC 76  Nile tilapia
XP_023182383    8 LCFLQDEKFDFNVSLSPvSSKGee-edDDEVF---VGHTEQCVSTDV------SSQPEEGGGDVQAVWTPLTADQLEAVC 77  southern platy...
XP_004086315   32 VLFLQDEKFDFDVSLSPaSSKDd----EDEVFEGPVEGEESRVSVSK-------ASELLEGDHVFSNWSPLTGERLDAVC 100 Japanese medaka
XP_011605872    9 LFFLHEEKFDFDMSMSPaSSNGd----EDEVFVEPVGRNERCVSVNV--------KTQLDGRQLRTSWSPLTGDQLEAVC 76  torafugu
10_pfamImport   1 LFFLHEEKFDFDISMSPaSSNGde--dEDEVFVEPVSHKERCTSTNV--------ETQLSDGQLRSSWSPLSGDQLEAVC 70 
KAE8616152      7 FTLLADEEFDFDISLSPtSSKEgnedcDDEVFVGPVRHKEKCVRASIQSGesDKGSPSLLSED--VSWSPLSGDKFVEIF 84  tropical clawe...
XP_016849676    1 ------------------S--------DDEVFVGPMGHKEKCIAVLLE-SqeGPKNKCSPSAQDAPTWSPLAGEKFVEIF 53  green anole

XP_005988504   83 REANQLAAQLEk----CTLKEKENSYRQKNDGSI---TNSFKFEKDTKGKIRLLKEERENRKSPRSPRRETYIVKDS 152 coelacanth
XP_005163070   87 KEAQQLASHIE--------QTITDSAAESSVVSS---CQTETFEDDAATKLNLFSKPAD-ILSP--IKRETFLVQDS 149 zebrafish
9_pfamImport   69 QEAQRVAGQLQ--------------CASLLVPPSvpdEATGAFSQDAEAQLAAVDRRAS-ALSP--VKRQTFCVQDS 128
XP_005454253   77 QEAHRLASQLQs----TVSHDENRDTTSMTMDTM---TEQEEFVEDAETRLGLLAQTTS-GVSP--NKRQTFCVQDS 143 Nile tilapia
XP_023182383   78 EEAHRLASQLQcrephVQKTNTTHTASDVDMNSM---ATTEEFIQDTEVKLGLLDHTAS-SLSP--IKRQTFCVQDS 148 southern platyfish
XP_004086315  101 QEAHSLVNQLQ------------DGKACGVEDAN---IAGEQFLQDSEAKKKVLCSSSG-ALSP--IKRQTFCVQDt 159 Japanese medaka
XP_011605872   77 QEAHKLANQLQsg-erSQSHSEDDKDNEATAAVT---TQPDEFVQDSQAKLHVFEQSNR-VLSP--IKRETFCVQES 146 torafugu
10_pfamImport  71 QEAHRLASQLQgg-erSRSHSEHEDTTSAVM------TQPEEFVQDSGAKLNVFEQSNR-VLSP--IKRETFCVQDS 137
KAE8616152     85 KEAHLVALQLE-----CFASDDQKEVQSSKNDTN---QLVEKFVQESKSKLNIFENLDN-SKTPVALKRETYCVQDS 152 tropical clawed frog
XP_016849676   54 KEAHLVALQLQ-----SASKTKRKNAGQQEEAKS---ATVEKFVQESKSKLKILERGIVTNKTPTSIKRETFYVAES 122 green anole
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