5OE7,3ZNV,3ZNX,3ZNZ,4KSJ,4KSK,4KSL,6I9C,6SAK


Conserved Protein Domain Family
OTU_OTUL
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cd22799: OTU_OTUL 
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OTU (ovarian tumor) domain of ubiquitin thioesterase otulin and similar proteins
Otulin, also called FAM105B, deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, or ubiquitin thioesterase Gumby, is a deubiquitinase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. It acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. Otulin belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in some cases an aspartate, as the catalytic dyad (or triad).
Links
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Statistics
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PSSM-Id: 438620
Aligned: 16 rows
Threshold Bit Score: 480.018
Created: 19-Nov-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 4 residue positions
Conserved feature residue pattern:[DE] C H NClick to see conserved feature residue pattern help
Evidence:
  • Comment:Active site residues have been identified from the tertiary structure of human otulin/FAM105B isopeptidase: Asp126, Cys129, His339, Asn341.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      #  #                              
5OE7_A         3 LSVAPemDIMDYCKKEWRGnTQKATCMKMGYEEVSqkfTSIRRVRGDNYCALRATLFQAMSQavglPPWLQDPELMLLPE 82  human
3ZNV_A         3 LSVAPemDIMDYCKKEWRGnTQKATCMKMGYEEVSqkfTSIRRVRGDNYCALRATLFQAMSQavglPPWLQDPELMLLPE 82  human
3ZNX_A         3 LSVAPemDIMDYCKKEWRGnTQKATCMKMGYEEVSqkfTSIRRVRGDNYCALRATLFQAMSQavglPPWLQDPELMLLPE 82  human
6I9C_A         3 LSVAPemDIMDYCKKEWRGnTQKATCMKMGYEEVSqkfTSIRRVRGDNYCALRATLFQAMSQavglPPWLQDPELMLLPE 82  human
Q96BN8        80 LSVAPemDIMDYCKKEWRGnTQKATCMKMGYEEVSqkfTSIRRVRGDNYCALRATLFQAMSQavglPPWLQDPELMLLPE 159 human
NP_001159487 120 SSVSAaeDLQTYSEKEWRGnTTKSQLIRKGYEAIAs-eFRLCRVRGDNYCALRATLFQVLSQskklPAWLQDSDIVKWPK 198 zebrafish
XP_007899897 403 SSLEPsvVILEYCAREWKSsTTKAQLMKKAYNTVHetfSSVRRVRGDNYCALRATLFQALSNie-lPKWIQKDTFLQFPE 481 elephant shark
XP_014352437 373 VSVSPkvDILDYCGKEWKGnTSKAKLMKKGYEAVAnkfISIRRVRGDNYCALRATLFQIFSQseevPAWLQNEDIAQIPE 452 coelacanth
XP_018124898 275 LGVGPemDIVEYCKKEWRGkTAVAQIMKKGYEQVSrsfVSIRRVRGDNYCALRATLFQALSQtaklPEWLDDAKLYQLPE 354 African clawed ...
XP_004935162  56 LSVAPemDILEYSKKEWRGnTPVAKSMRKGYEAVArkfASIRQVRGDNYCALRATLFQALSQatqlPCWMQSEDFTMLPE 135 chicken

Feature 1                                                                                        
5OE7_A        83 KLISky-nWIKQWKLGlkfdgkneDLVDKIKESLTLLRKKWAGLAEmrtAEARQIACDELFTneaEEYSLYEAVKFLMLN 161 human
3ZNV_A        83 KLISky-nWIKQWKLGlkfdgkneDLVDKIKESLTLLRKKWAGLAEmrtAEARQIACDELFTneaEEYSLYEAVKFLMLN 161 human
3ZNX_A        83 KLISky-nWIKQWKLGlkfdgkneDLVDKIKESLTLLRKKWAGLAEmrtAEARQIACDELFTneaEEYSLYEAVKFLMLN 161 human
6I9C_A        83 KLISky-nWIKQWKLGlkfdgkneDLVDKIKESLTLLRKKWAGLAEmrtAEARQIACDELFTneaEEYSLYEAVKFLMLN 161 human
Q96BN8       160 KLISky-nWIKQWKLGlkfdgkneDLVDKIKESLTLLRKKWAGLAEmrtAEARQIACDELFTneaEEYSLYEAVKFLMLN 238 human
NP_001159487 199 ELHSde-nFLKEWQFPles---kkNNVQHLEQCLDLLKKKWQEAVQcksLAERERMSQQVFRglnEEYELLEALKFLMLR 274 zebrafish
XP_007899897 482 KLITenysWIKQWNFGaqiy-gneDPVEKLKEYLILLKCKWTDVCGmasLEERQSACEKIFSgeiEEYSLFEALKFLMLV 560 elephant shark
XP_014352437 453 KLAKre-dLMSQWRLRqspegekeNPVLKLKEYLELLKKKWADLCGienAEERQAVCDKIFEdeeEEYCLYEAVKLLMFN 531 coelacanth
XP_018124898 355 KFSTky-eWIKLWRFWnvh--gdkNVGIRLKEYVELLKEKWAALSSmktPEERQAACNEIFTtegEEYCLYEGVKFLMLK 431 African clawed ...
XP_004935162 136 NLLSky-dWIKQWQLKekpsrktgEISDEIKEYLLLLKKKWKCVSDikcPVEKQEACDELFKneeEEYRLYEALKFLMLN 214 chicken

Feature 1                                                                                        
5OE7_A       162 RAIELYNDKEKgkEVPFFSVLLFARDTSNDPGQLLRNHLNQvGHTGGLEQVEMFLLAYAVRHTIQVYRLSKynTEEFITV 241 human
3ZNV_A       162 RAIELYNDKEKgkEVPFFSVLLFARDTSNDPGQLLRNHLNQvGHTGGLEQVEMFLLAYAVRHTIQVYRLSKynTEEFITV 241 human
3ZNX_A       162 RAIELYNDKEKgkEVPFFSVLLFARDTSNDPGQLLRNHLNQvGHTGGLEQVEMFLLAYAVRHTIQVYRLSKynTEEFITV 241 human
6I9C_A       162 RAIELYNDKEKgkEVPFFSVLLFARDTSNDPGQLLRNHLNQvRHTGGLEQVEMFLLAYAVRHTIQVYRLSKynTEEFITV 241 human
Q96BN8       239 RAIELYNDKEKgkEVPFFSVLLFARDTSNDPGQLLRNHLNQvGHTGGLEQVEMFLLAYAVRHTIQVYRLSKynTEEFITV 318 human
NP_001159487 275 TAAQLHLNMEKgsDVPEFCWLLFARDSSKCPKTFLTNHLRHvGFSGGLEQVEMCLLGHSLQQTIKVFRLYKcdTEEFITY 354 zebrafish
XP_007899897 561 KAIELDRDKLQekEVPLFCWLLFARDTSDNPYLFMKNHLNHvGYTGGLDQVEMFLLGYTMQLTIRVFRLYKfgTDEFITF 640 elephant shark
XP_014352437 532 MAINLNDEKEEgkDVPVFVWLLFARDTCTNPMELLKNHLNQvGNSGGLEQVEMFLLGYALQVTIHVYRLYRceTDEFITF 611 coelacanth
XP_018124898 432 TAVDLYKANEErmEVPVFSWLLFARNTSSNPCEFMKNHLNQvGHSAGLEQVEMFLLGYALQHTIKVYRLYKcgTDEFITY 511 African clawed ...
XP_004935162 215 TAIELYNDEKNrrRVPIFSLLLFACDTSSSPCQLMHNHLNQiGHSGGLEQVEMFLLAYALQYTIQVYRLYKfsTDELITF 294 chicken

Feature 1                            # #    
5OE7_A       242 YPTDppkDWPVVTLIAEDDRHYNIPVR 268 human
3ZNV_A       242 YPTDppkDWPVVTLIAEDDRHYNIPVR 268 human
3ZNX_A       242 YPTDppkDWPVVTLIAEADRHYNIPVR 268 human
6I9C_A       242 YPTDppkDWPVVTLIAEDDRHYNIPVR 268 human
Q96BN8       319 YPTDppkDWPVVTLIAEDDRHYNIPVR 345 human
NP_001159487 355 YPNDhknDWPHLVLLTEDDRHYNALIP 381 zebrafish
XP_007899897 641 YPDDhqeDWPVITLITEDDRHYNVLVG 667 elephant shark
XP_014352437 612 YPDDhkeDWPQVTLLTEDDRHYNVPVG 638 coelacanth
XP_018124898 512 YPNDq-tNWPIVTLITEDDRHYNVPVR 537 African clawed frog
XP_004935162 295 HPSNpeeDWPVVTLITEDDRHYNILVR 321 chicken

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