Conserved Protein Domain Family
G_path_suppress

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pfam15991: G_path_suppress 
G-protein pathway suppressor
This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Statistics
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PSSM-Id: 464961
Aligned: 13 rows
Threshold Bit Score: 113.092
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7SZ61                5 LERPKLSNAMARALHKHIMRERERKRQEEEEvdKMMEQKLKEEEERKRKkemEERMSLEETKEQIMKMGVKLQGLQEEKH 84  zebrafish
XP_009016171         44 IVRPKMTKSTYEALKKYILKDREKKKQEQEQ--DKEQERLKKEREMKKKkeeEDNLTLEQTKEQILQLEAKLASLKQEKH 121
EKC23845              6 IDRPKMTKTMYQALKRHIMKERERKKQEQEQd-AMMMERIKKEEEMRKKkeqEDSLTLEQTKEQIAQLDKKMEDLKAEKH 84 
XP_021784357          5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRKKkemEERMSLEETKEQILKLEEKLLALQEEKH 84 
XP_007483267          5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRKKkemEERMSLEETKEQILKLQEKLLALQEEKH 84 
XP_005997970          5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRRKkemEERMSLEETKEQIHKLDGKLSALQEEKH 84 
XP_002403798          5 IERPKMSLQMWAALKAHIMRERERKKQEQEA--DEAIERLRREQELKRK---QDAMTLEEIKDQVSQSEKKLKELKDEKH 79 
Q17LP6               19 VVKTEKEEQLWNALKRHIMRERERKKQELEA--EVEEERLRKEREAREK---QDVMTLGETKEQIQMLEKQLQELRNEKQ 93  yellow f...
ETN65319             18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--EVEEERLRREREEREK---QDVMTLGETKEQILILEKNLEELRNEKQ 92 
XP_001688546         18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--EVEEERLRREREEREK---QDVMTLGETKEQILMLEKNLDELRNEKQ 92 
Q7JQT8               16 AAKAERAEKLRGALKGFIVADRQRRQEEFEA--QCEEQRLRREREEVER---QNQVALDDTRGQITRLDEQLADLHSQKH 90  fruit fly
XP_002015550         16 AAKAERAEKLRGALRKFIVADRQRRQGEYDA--YCEQMRVRREEEERER---ENQQALEETRDEITKLDEQLADLHSQKH 90 
WGS:AAPU:GI19462-PA  17 AA-AERAEKLRGSLKGFILAERQRRQEEYER--QCEELRLRREQEARER---ENNLSLEDTRGQISRLDEQLADLHQKKH 90 
Q7SZ61               85 QLFLQLKKVLH-EEEKRRR---KE-QSDMTTLts-----------------------aTYQANmpihpsqhiLSMQagqv 136 zebrafish
XP_009016171        122 ELFSQLKKVLHqENDLRQRnqlKEqQNEQANLqqqmltg-------------lgvnaqFFMQQqqqqqrqkyLSISsq-- 186
EKC23845             85 DLFSQLKKVLHqEDETRKKaqlKE-QSELQIMqhs---------------------tvLGLPH----------AMTgrp- 131
XP_021784357         85 QLFLQLKKVLH-EEEKRRR---KE-QSDLTTLts-----------------------aAYQQSltvhtgthlLSMQgspg 136
XP_007483267         85 QLFLQLKKVLH-EEEKRRR---KE-QSDLTTLts-----------------------aTYQQGlavhtgthlLSMQgspg 136
XP_005997970         85 QLFLQLKKVLH-EEEKRRR---KE-QSDMTTLn------------------------aGYQPGmtvhssqhlINMQgspv 135
XP_002403798         80 QLFMQLKKVLH-EDDTRRRaliKE-ANEMAAAaqaaanqayashhqalnavgvnppqpLYIQNlsrt--pvlYKMSpqpp 155
Q17LP6               94 QLFLQLKKVLN-EDDNRKRq-lKE-SVEMFAVhnip-------------------qqqTYLPQ---------RTTTampp 142 yellow f...
ETN65319             93 QLFLQLKKVLN-EDDNRKRq-mKE---EMMAIqni--------------------pqqIFLPQ---------RSICpphq 138
XP_001688546         93 QLFLQLKKVLN-EDDNRKRq-mKE---EMFAIqni--------------------pqqIFLPQ---------RSMPphqq 138
Q7JQT8               91 QLTVQLKKVLN-EDETRKKl-aKE-N-ELFAIqqaa------------------asspVFLPP---------LRLQhqhh 139 fruit fly
XP_002015550         91 QLLVQLKKVLN-EDETRKKq-aKE-N-ELFAMqqaaa----------------tvatsVFLPT---------LRLqhhqq 141
WGS:AAPU:GI19462-PA  91 ELLVQLKKVLN-DDETRKKq-aKE-N-ELFAMqqeaaa--------------taaraqVFLPP---------GRLhhqlp 143
Q7SZ61              137 ------------------------shgrPAVLLG-ERSKQLFQSPVIparhfqsqPGFSAGGSEHGQysgaqpghspygv 191 zebrafish
XP_009016171        187 ---------------------------hAPPTQTsLKRPRSPSPSTT--------PSHYPHFAGSGS------------- 218
EKC23845            132 ------------------------------------ilyRPPQPQMVqssfpqsqAG--PGYPTQSShafqqagy----- 168
XP_021784357        137 ------------------------ghnrPGTLMAaDRAKQMFGPQVLttrhyvgsAAAFAGTPEHGQfqgspggaygta- 191
XP_007483267        137 ------------------------ghsrPGTLMSaDRAKQMFGPQVLttrhfvgsTA-FAGTSEHGQfqgspggayga-- 189
XP_005997970        136 ------------------------ghsrPGPLLG-ERSKQMFAAPVItgrpypgqPGFTPGTPEHSQyqssqsghgayhv 190
XP_002403798        156 qg-----------------------ttmnqqHPNcLKRTRSPSPPQSiph---sqTTYQPQFAYKAQvtafg-------- 201
Q17LP6              143 hq--------------------qhlihkTTPPVNvAKRTHSPSPqgy-----ykqTTASPAYPPPQPqkleegrrgpg-- 195 yellow f...
ETN65319            139 q----------------------hlihkGNPQVNvAKRTHSPSSPQHlqgy-ykqPNLN-NQIYHSPqkmdegrrsge-- 192
XP_001688546        139 qhmmhkvsqpevmlsseriftdaypnlqGNPQVNvGKRTHSPSPVQHvqgy-ykqPNLN-NQPYALPqk----------- 205
Q7JQT8              140 tl---------------------mqklpSGGQPG--KRGRSPSPPSQqqay-yksAA---SYAQqkhddyrraad----- 187 fruit fly
XP_002015550        142 -----------------------lakppPGNQSG--KRGRSPSPPNhay---yksTA---SFAQqkhddyrraad----- 185
WGS:AAPU:GI19462-PA 144 ll--------------------qkqpppPGSQSTtVKRGRSPSPPSQqhqayyksPA---NYATQQPqkhddfrrgtd-- 198
Q7SZ61              192 tqtqhtspfassqpvpaNYASSSQLrg----------------------asAFQT------MQYLPHQQ-QGYAVHShf- 241 zebrafish
XP_009016171        219 -----------------SYPNSGSGggsvgviglgqgytgkgdgpaikqgsSYTTvllpqnHQPPPPNLiSQSPSQQ--- 278
EKC23845            169 ----------vpskspvKYNPGSQS--------------------------AFSSysnpyaHQQTKQLQeSGFPAYRm-- 210
XP_021784357        192 ------qppphygptqpAYSPSQQLra----------------------psAFPA------VQYLSQPQpQPYAVHGhfq 237
XP_007483267        190 ------qppphygptqpGYSPSQQLra----------------------psAFPA------VQYLSQPQpQSYAVHGhyq 235
XP_005997970        191 g--qsqhafgggqpvsmSYTGSQQLrg----------------------tpTFPT------MQYLSSQQ-SGYAVHGpf- 238
XP_002403798        202 -------------pklvPYPTVSSGqt----------------------pvYYTA------HHIVPANDaAAAAAAA--- 237
Q17LP6              196 ------evaravlwnksQYCPPGTL--------------------------FYPAna------pQPPN----QPDTRqp- 232 yellow f...
ETN65319            193 -------varavlwnksQYCPPVG---------------------------FYPSnpp------snPP----QPDVRqp- 227
XP_001688546        206 ----------------sQYCPPVG---------------------------FYPGappanpQDNRPPP----QP------ 232
Q7JQT8              188 ------yarlswnktaaQYPGTGTV--------------------------FYQTva--------pPPTtQHQADARl-- 225 fruit fly
XP_002015550        186 ------yarlswnkttaQYPSTGTL--------------------------FYQTta--------aPPTtQQQADARl-- 223
WGS:AAPU:GI19462-PA 199 ------yakmswnkstaQYPSTGTL--------------------------FYQTst--------aPATtQHQADARl-- 236
Q7SZ61              242 tsQPGY---IPSAGIPLQKQle-----------------haNQQSGFTDSS-PLRPM-HPQALHVSAASLLSTPPIA 296 zebrafish
XP_009016171        279 --QHSYiqqQQQQIQQQQRQ---------------------QAPSPYQIPS-NQKYHqSSSSSSPASGYFPSSNHFS 331
EKC23845            211 -qQPGYittQHGSSIPLQKQle-----------------haNQQSGFNEEKyKLQQQnSAIRGVAPLPGQQSMMHQP 269
XP_021784357        238 ptQTGFl--QPGGALSLQKQmehanqqtgfsdsvsmapwevrvrdmlrgasvclrpsllcsplcapctprlciqpld 312
XP_007483267        236 ppQTGFl--QPGNALSLQKQle-----------------haNQQSGFSDSS-SLRPM-HPQALH-PTPGLLATPQLP 290
XP_005997970        239 agQQGF--------IPLQKQle-----------------haNQQSGFTDSS-TLRPMqHPQALH-PNPGLLAASQIP 288
XP_002403798        238 --ATIY---GAGYATSFTTA---------------------APPQPHPTES-TLKQ--HVVAPPSSQGYA--ASHLP 283
Q17LP6              233 qpQIIYppyQGGLPMSIRQSyqv---------------dlaPQPGP-APPG-PQKAPeLIKPGPGPGPAPGNVYHIt 292 yellow feve...
ETN65319            228 -qQILYp-yQSNLTIPMRQYvdipptqqhqqqhqqhqqqhlHQSGLLKQSE-PPHMVqSSKAIMGQ-AAQPNIYHIs 300
XP_001688546        233 --QILYp-yQSSLTIPMRQYvd-----------------ipSQPGPMVQPK-PEQLIvSGKVGPLP-PSQANLYHIP 287
Q7JQT8              226 --QSIY-----NYNLPLRQAyhv------------------dlPSATVSKP-PDSQ--SPKAPSQSQPMQ--VLHIn 272 fruit fly
XP_002015550        224 --PAIY-----NYALPLRQAyhv------------------elPSATVSKA-SDTQ--SPKA----QPMQ--VLHIn 266
WGS:AAPU:GI19462-PA 237 --QSIY-----NYGLPLRPPyhv---------------elqPGPSATVSKA-PGSQSpSPKA----QPMQ--VLHIn 284
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