Conserved Protein Domain Family
CCDC106
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pfam15794: CCDC106 (this model, PSSM-Id:406275 is obsolete and has been replaced by 464874)
Coiled-coil domain-containing protein 106
CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumorigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.
Links
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Statistics
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PSSM-Id: 406275
Aligned: 8 rows
Threshold Bit Score: 211.984
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011479210  84 LVSNLRAHLYVSLEKNSWLQKRIEELEEERNFLRCQLNRFIVSMSPeatewcgdaqravkvqpncspsppspmttrsgmt 163 Japanese medaka
XP_006634190  84 TITKLQCLLESKQERINFLEKQVEDLQQDRKFLRSQIENLTSAKSI---------------------------------- 129 spotted gar
XP_002664363 236 SLEQAKKTIEIQKEKILHLQEKVDFLMDDRNYLRSRLEDAL--------------------------------------- 276 zebrafish
XP_006005149  83 FMTNLRNQLNLTLEKNSWLQKRIEDLEEERDFLRCQLDKFISSTKSd--------------------------------- 129 coelacanth
PNI14924      22 LMNSVKAQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMe--------------------------------- 68  chimpanzee
XP_004916271  57 LMNSMKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISCTKSd--------------------------------- 103 tropical clawed...
XP_031155399  73 VITNLRTQLQISLEKNSWLQKRIEDLEEERDFLRCQLDRFIFSTKSqgqeqs---------------------------- 124 pike-perch
XP_019217595  58 LLNKEQEELTFLKEKLEWQKMRIEELEGERDFLRRQLSSFTK-------------------------------------- 99  Nile tilapia

XP_011479210 164 lkrlqdsGprTRRNI--------------SVPVKQEFHIK--------------ED------------------------ 191 Japanese medaka
XP_006634190 130 -------TedSKPGK--------------SLYSESKPRKR--------------SR------------------------ 150 spotted gar
XP_002664363 277 ----------RLRCE--------------TVNSPALTASS--------------ST------------------------ 294 zebrafish
XP_006005149 130 -------AvsEYESR--------------MKQNLR--------------------------------------------- 143 coelacanth
PNI14924      69 -------A--EDHCR--------------MKPGPRRME-G--------------DS------------------------ 86  chimpanzee
XP_004916271 104 -------S--EEHSR--------------IKQTNWR---S--------------EG------------------------ 119 tropical clawed...
XP_031155399 125 ----qsqysnGYESRrfnwrirreeerpvEQKTESQHFPSrqfiqrrpgpptmvPSknhvsspltnqlasinalfnstqs 200 pike-perch
XP_019217595 100 --------------------------------QPKDQPFN--------------DP------------------------ 109 Nile tilapia

XP_011479210 192 ---------------KYYTEDEYVEEEEEEEAEEEEEDSSVE------------------------------------KG 220 Japanese medaka
XP_006634190 151 ---------------TASSSSSFSNDSGSDISLTTVSSGTSN------------------------------------DG 179 spotted gar
XP_002664363 295 ---------------IVTSQKNQSTDTSSDSSESTDSSDSEP------------------------------------TA 323 zebrafish
XP_006005149 144 -------------------NGNISDDEDGLGTQSPSSDAGCS------------------------------------EL 168 coelacanth
PNI14924      87 ---------------RGGAGGEASDPESAASSLSGASEEGSA------------------------------------SE 115 chimpanzee
XP_004916271 120 ---------------KECCNEDLTDNDSMLS-VSAYSEEGDT------------------------------------LA 147 tropical clawed...
XP_031155399 201 qallqghshstpnttASGSSSNSATRASM-NEMSGHSNIGPGntndslsllgesdeyleqdsyleeeemisgedvmqdTI 279 pike-perch
XP_019217595 110 ---------------FSSKASENSDSSSAFSSVSSVWSSSSS------------------------------------FP 138 Nile tilapia

XP_011479210 221 SKKKGRarnageprmKMRRIFRITHGRERQRVKDPDGVLIRYKKILTTYQRVRSMSRAFQIHGVDRNTMASTSPIAELLL 300 Japanese medaka
XP_006634190 180 KKKRHH---------KDKRRGKKAKDYSRKRATGVQYVIHRYKQVLSAFNKKKSMSGAFRHYGIDRNTIANTAPIAELHL 250 spotted gar
XP_002664363 324 KKKKKGk-------kSKRQKKSKTKMIDIKRVRTPEDSINRYNKVLQLVRDGLSKAEAYNKVKIDRNTIVKQAPIAELAT 396 zebrafish
XP_006005149 169 DRKKLRgr------gARGKQPLRVKVRDRQRVKDAEDVLCRYKKILTSFQKLKSMSRAFEYHGVDRNTVALTTPIAELLI 242 coelacanth
PNI14924     116 RRRQKQkg------gASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLI 189 chimpanzee
XP_004916271 148 DTKRQRqk-----gsCNKRGFCKPKIRERQRVKDADGVLCRYKKILSTFQKLKSMSRAFEHHRVDRNTVALSTPIAELLI 222 tropical clawed...
XP_031155399 280 NSNRHQl--------KRRRVFRAP--RERQRVKDAAGVLFRYKKILLTYQRLKNMSKAFQIHGVDRNTVASTTPIAELLL 349 pike-perch
XP_019217595 139 KKRKQKykk----khSRAKKPKKEQKKLRQHVQTPNDIVQRCKSPLKTFPRTKTMTKAFQKHGLDRNTVVSTSSVGELAI 214 Nile tilapia

XP_011479210 301 VAPEKVSEVGEFEASKEKLLDYARRCYKTM--DEETHAKVQSMKKTHKLLPIS 351 Japanese medaka
XP_006634190 251 AAKEMLQVVGLFHPREETLVKYAQKCAVVIenDENLSRKIEQMKATGELLPIT 303 spotted gar
XP_002664363 397 ANPTEFKSLRATFKKGESVQEFANLCLTRClaQSNM-EILKQLKESNALLDIf 448 zebrafish
XP_006005149 243 VAPEKVAEIGEFDSSKERLLEYSKRCFMAL--DEETLMKVQALKRNKLLLPIS 293 coelacanth
PNI14924     190 VAPEKLAEVGEFDPSKERLLEYSRRCFLAL--DDETLKKVQALKKSKLLLPIT 240 chimpanzee
XP_004916271 223 VAPEKIAEVGEFDPSKERLLEYSRRCFLAL--DEETLEKVQTLKKNKLLLPIT 273 tropical clawed frog
XP_031155399 350 VAPEKVAEVGEFDPSKEKLLDYARRCYTAL--DEETLSRVQALKKNNLLLPIS 400 pike-perch
XP_019217595 215 AVPNVYQELLSNRSSGETVLAFAKRCEAAIqgSDEV--KKQNRkyegrwyfas 265 Nile tilapia
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