Conserved Protein Domain Family
NET-5_like_LEL
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cd03165: NET-5_like_LEL 
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.
Links
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Statistics
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PSSM-Id: 239418
Aligned: 18 rows
Threshold Bit Score: 114.001
Created: 7-Nov-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:dimeric assembly observed in the CD81 crystal is predicted to resemble quaternary structure of intact CD81 at the cell surface
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #    #   # ##  #                     #  ##  ##                                 
AAH75913   105 FSYQDQIDLYAQNDLKKGLQLFgteg------nigLTNAWSIVQTDFRCCGVTNHTDWfqvy---ntsrVPDSCCLEy-- 173  zebrafish
XP_421038  382 FVYTDKIDKYAQRDLKKGLHLYgtdg------nigLTNAWSIIQTDFRCCGVSNYTDWfevy---nttrVPDSCCLEf-- 450  chicken
EAA05254   110 YVFREKVSQTMGDEMRSSMSLYgsr--------rsITTAWDETQERLKCCGVRSYSDWrg--------dIPQSCCQRtld 173  Anopheles gambia...
XP_394297  153 FIFREHLAKSLKDELLFGIEKHynltr----epgtLPAIWDHIHTEFHCCGVRDYTDWfridawptedrVPDSCCVQr-- 226  honey bee
EAA05299    24 YAFRERIALGLQDQMYESLDQYgrr--------rlTTVSWDMTQEDLQCCGVEDFRDWne--------rIPDSCCMDdyg 87   Anopheles gambia...
XP_624507  111 YVFREKLMNTLEREMSSSMRLYdsr--------kaVREAWDMTQSKLHCCGVNGWRDWgl--------sIPQSCCREiqp 174  honey bee
AAH73257   105 LTYTEQFHNYAQEDLKKGLQLYnttg------nlgLTNAWDIVQTEFRCCGVKNASDWlet-----kdsVPHTCCAEh-- 171  African clawed frog
NP_730317  110 YVFRERVQQTMRQEMRSTMALYgsr--------reITQAWDLTQERLQCCGVDTWHDWnry------gpVPESCCQElfg 175  fruit fly
XP_684965 1167 SLYHEELDKKAKDDLREGMKGYskn--------dgLRKSWDNMQMIFKCCGVSNHTDWhnkt---sdgkLPGSCCSNd-- 1233 zebrafish
EAA04279   105 FVFRGGIGRMLTQELKYGIEKHynvsdrggfltpsVASIWDNLQVDLQCCGVSSYEDWydisawpgerwVPQSCCRSqyn 184  Anopheles gambia...

Feature 1                                                    
AAH75913   174 ------------sDNCGLenp-----gtwWTAPCYERVKGWLQENL 202  zebrafish
XP_421038  451 ------------sENCGLhsp-----gtwWKDSCYEAVKIWLQENL 479  chicken
EAA05254   174 -----------gyKPCIEnpsp----eniYINGCLEITSSYIRDNA 204  Anopheles gambiae str. PEST
XP_394297  227 ------------eRYCGRldsegrnkelwYKEGCATAIQMWLVTRL 260  honey bee
EAA05299    88 ----------arkRPCQQlqts----ltiYRTGCYEAITQTLVRNG 119  Anopheles gambiae str. PEST
XP_624507  175 ----------gqrFNCNSgpdtv-npsnaYLVGCINGTQIYLQKHA 209  honey bee
AAH73257   172 ------------sPACKSnps------lwWQDACYNKVRKWVETNI 199  African clawed frog
NP_730317  176 ----------gqrKECTIfpti----tnlYNQGCLYVTTNFIRDHA 207  fruit fly
XP_684965 1234 ------------pSSCRH-----------WEEPCYEKAKQWLLTNI 1256 zebrafish
EAA04279   185 slfsegsgdelanVDCRKagnp----allWDKSCGQILQMWFVQRL 226  Anopheles gambiae str. PEST

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