Conserved Protein Domain Family
Commd10
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cd04758: Commd10 
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.
Links
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Statistics
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PSSM-Id: 240106
Aligned: 11 rows
Threshold Bit Score: 186.432
Created: 12-Feb-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001039088  12 IKHAVSIINSMDMGKFprllsrif-------------------------qklhlkaERSFSEEEEEKLQAAFALDKq--- 63  western clawed ...
XP_001303457   7 LSEALKIVEKIPQRPFaqllrrla-------------------------ialkerdNIPFSEDEVQILLEQFKLTPt--- 58  Trichomonas vag...
AAI25988      12 IKHAVSIINSMDVGKFprllsriv-------------------------qklhlkaERSFSDEEEEKLQAAFALDKq--- 63  African clawed ...
XP_780543     11 IKKAVGLINEIDSSKFprllqrii-------------------------qklhlrdELSFTEDEEEKLEDALGMQRn--- 62  purple urchin
NP_572738     12 AREGIKIINALPYETFttvlfythrqmspsvasasatsstvgtsvtttgrvdssteENPTSNTEPEYTLEELERLVgvpr 91  fruit fly
EAT43341      15 AKTVAFCNEGITDECFsnmleylfrt--------------------idnsstggnqSQTDTEAELANLRAATSQLSeq-- 72  yellow fever mo...
AAF28983      24 MKKAVSLINAIDTGRFprlltril-------------------------qklhlkaESSFSEEEEEKLQAAFSLEKq--- 75  human
NP_001017895  11 IKAAVTHINSIDNSKFsrlltri--------------------------lqklhlkERSFSQEEEEKLQSALSLERh--- 61  zebrafish
AAL92188      13 FNDSIELINKLETPRFqkil--------------------------------trvnERIFTESEENILQNLFKITSl--- 57  Dictyostelium d...
NP_001026614  12 IRRAVLLLNAVDPGRFprllsrll-------------------------qrlhlkaETSFSEEEEEKLQIAFSLEKq--- 63  chicken
XP_973616     12 LQGGVSLINSLNRNKFnlllkh----------------------------ivqsetDEIFTQAELAKLSESLKLDDa--- 60  red flour beetle

NP_001039088  64 -dLNLVLETISFILEQAVYHnlkatvLRQQLENIHLEQSKveaf--vnaWEISGQDTVEKFRQRIL--APKKLETTAWQL 138 western clawed ...
XP_001303457  59 -eLESFFSACQYVLQQAACYsfn-seKTQMYASQCGVPDEiaec-fsavWDAEGEDLINALKSRTL--TDDVLNSTSWRL 133 Trichomonas vag...
AAI25988      64 -dLNLVLETIAFILEQAVYHnmkttvLRQQLENIHLEQSKveaf--vnaWEVSGQDTVEKFRQRIL--APKKLETTAWQL 138 African clawed ...
XP_780543     63 -dLELVLETTAFILEQAAYHltkpanLSQQLQSIHLAEEKvslf--tkaWTSLGKDVVEKLRKRTL--SPNQLTDVNWRL 137 purple urchin
NP_572738     92 qdFLLLIKTFSYILRRISTFiikpslLQRELREKLQLEDEakidailrlWVRETTPIMNNLASKRY--ESNVIEDVAWKL 169 fruit fly
EAT43341      73 -eFKLTMQSLAYLVKRSLKFmlkpsrMQTDLRNHLQLTENksnc-fvkhWIQSTKIVLDALATADDdgSSNQLEDVSWKV 150 yellow fever mo...
AAF28983      76 -dLHLVLETISFILEQAVYHnvkpaaLQQQLENIHLRQDKaeaf--vntWSSMGQETVEKFRQRIL--APCKLETVGWQL 150 human
NP_001017895  62 -tLQLLLETVSFILEQAAYHnvkpasLRQQLENICISPQKaevf--sqmWAADAADLLEKIRLGIF--APMKLDRVSWQL 136 zebrafish
AAL92188      58 -eFKGILECCSFIFEQTAYYslspnnLVNQLKKTMLNDDKtscf--qsvWEDNSEHVLNFLRTQSI--APLQLNEIGWRL 132 Dictyostelium d...
NP_001026614  64 -dLHLVLEAISFILEQAVYHnlkpasLQQQLQSIHLDQDKaeaf--anaWAAGGQETIEKFRQRVL--TPQKLETIGWQL 138 chicken
XP_973616     61 -nVQLLIQSIAHIFKQASKVilkptiLQDQLVEKLKFESDka------eDFVKLWTQETKRNFDVE--NSKNLDNISWEL 131 red flour beetle

NP_001039088 139 NLQMAQSTQAKMKSPQAVIELGVSSedt-----------kslEKVFVEFNHEELLEFYNKLETIQAQLDSL 198 western clawed frog
XP_001303457 134 NLKAAENGKAPTKQPIMLLDLNVTGk----------------KPITIQFNHEELSKFYDQIEQIQQQVDHL 188 Trichomonas vaginalis G3
AAI25988     139 NLQMAQSTQAKMKSPQAVIELGVSSedt-----------knlEKVFVEFNHKELLEFYNKLETIQAQLDSL 198 African clawed frog
XP_780543    138 NLQMSQQNQTKLKMPNAMLELGITTdhg------------dkDRIRMEFTHEELFAFYNQLETVQGQLDSL 196 purple urchin
NP_572738    170 NMEISSHCQQREKTPLAVLQMKTAVg----------------EDINIEMTQPELMELYNQFESIQGELDAM 224 fruit fly
EAT43341     151 RAQLSSEPRQKDKLALGQLELKTGS-----------------RTINLELNSAEIVEFYNQLERIQVELDAL 204 yellow fever mosquito
AAF28983     151 NLQMAHSAQAKLKSPQAVLQLGVNNeds-----------kslEKVLVEFSHKELFDFYNKLETIQAQLDSL 210 human
NP_001017895 137 NLQMARSDESRLKAPHAVLNLGLRAedhs----------erlQDVFLEFSHQDLLEFYNQMETVQTQLDSL 197 zebrafish
AAL92188     133 HYQMSSSTAIKRNASAIMELNFNNNnnnnnnnnnnnnnninnDKMILEFNKEQLLEFYNKLESIQEKLDTL 203 Dictyostelium discoideum
NP_001026614 139 NLQMSASTQAKLKSPRAVLELGVSDed--------------sKVHKLEPSVGCLRLLSNGTVSMKEEKNQN 195 chicken
XP_973616    132 NVEAASSFTNKERFVHSRLQMALVSvdg-----------eekENVVLELDEDELKHLYNTLEKIQNKLDSI 191 red flour beetle
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