1IML


Conserved Protein Domain Family
LIM_CRIP
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cd09478: LIM_CRIP 
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The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)
The LIM domain of Cysteine-Rich Intestinal Protein (CRIP): CRIP is a short protein with only one LIM domain. CRIP gene is developmentally regulated and can be induced by glucocorticoid hormones during the first three postnatal weeks. The domain shows close sequence homology to LIM domain of thymus LIM protein. However, unlike the TLP proteins which have two LIM domains, the members of this family have only one LIM domain. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
Links
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Statistics
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PSSM-Id: 188862
Aligned: 8 rows
Threshold Bit Score: 94.1748
Created: 31-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:1IML_A: Rat TLP like protein LIM domain binds Zn
  • Comment: The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                 #  #  #  #                 #   # 
1IML_A         3 CPKCDKEVYFAERVtSLGKDWHRPCLKCEKCGKTLTsGGHAEHEGKPYCNHPCY 56  black rat
NP_001087271   4 CPKCQKEVYFAEKVsSLGKDWHRPCLKCEKCSKTLSpGSHAEHDGKPYCNQPCY 57  African clawed frog
XP_422218    114 CPRCGKRVYFAEKVtSLGKDWHRPCLRCEKCNKTLTsGGHAEHDGKPYCNHPCY 167 chicken
XP_002131797   4 CPKCNKNVYFAEKVtSLGKDWHRPCLKCEKCGKTLNpGSHAEHDGKPYCNNPCY 57  Ciona intestinalis
XP_001624716   4 CPKCSKEVYFAEKVtSLGKDWHRPCLRCQKCNKTLSpGSHAEHGGKPYCHNPCY 57  starlet sea anemone
AAX30636       3 CPSCDKEVYFAERVsSLGKDWHRPCLKCEKCKKTLTpGSHCEHAGKPYCQIPCY 56  Schistosoma japonicum
NP_001153291   4 CPKCQKEVYFAERVtSLGKDWHRPCLKCEKCNKTLSaGSHAEHEGKPYCNNPCY 57  zebrafish
XP_002762515  81 CSKCDKEVYFSERVtSLAKDWHQPCLKCEKRGKALTsGDHAEHDSKPCYNHRCY 134 white-tufted-ear marmoset

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