1OEC,2PSQ,3CLY,2PVF


Conserved Protein Domain Family
PTKc_FGFR2

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cd05101: PTKc_FGFR2 
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270679
Aligned: 7 rows
Threshold Bit Score: 663.636
Created: 10-Jul-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3CLY; Human FGFR2 tyr kinase binds Mg2-AMP-PCP; contacts at 4A.
  • Structure:2PVF; Human FGFR2 try kinase binds Mg2-AMP-PCP; contacts at 4A.
  • Structure:1OEC; Human FGFR2 tyr kinase binds an inhibitor; defined at 4A contacts.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    ## #    #                   # #                # 
1OEC_A      4 DTPMLAGVsEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 83  human
NP_990650 458 DAPMLAGVsEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEM 537 chicken
Q03364    446 DAMPLANVsEYELPHDPMWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSEM 525 African clawed frog
Q8JG38    452 SSAHDDPIpEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 531 zebrafish
2PSQ_A     58 DTPMLAGVsEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 137 human
3CLY_A     12 QDPMLAGVsEYELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 91  human
2PVF_A     12 QDPMLAGVsEYELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 91  human
Feature 1                                 ####   #                                            
1OEC_A     84 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGME 163 human
NP_990650 538 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGME 617 chicken
Q03364    526 EMMKMIGKHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGME 605 African clawed frog
Q8JG38    532 EMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGME 611 zebrafish
2PSQ_A    138 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGME 217 human
3CLY_A     92 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGME 171 human
2PVF_A     92 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEXSYDINRVPEEQMTFKDLVSCTYQLARGME 171 human
Feature 1                   ## #          #                                                   
1OEC_A    164 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 243 human
NP_990650 618 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 697 chicken
Q03364    606 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 685 African clawed frog
Q8JG38    612 YLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 691 zebrafish
2PSQ_A    218 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 297 human
3CLY_A    172 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDXXKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 251 human
2PVF_A    172 YLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDXXKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 251 human
Feature 1                                                                              
1OEC_A    244 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 316 human
NP_990650 698 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWQAVPSQRPTFKQLVEDLDRILTLTTNEE 770 chicken
Q03364    686 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRILTLTTNEE 758 African clawed frog
Q8JG38    692 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEE 764 zebrafish
2PSQ_A    298 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 370 human
3CLY_A    252 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 324 human
2PVF_A    252 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 324 human

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