5H65,5UN7


Conserved Protein Domain Family
Pot1C
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cd20374: Pot1C 
Protection Of Telomeres Protein 1 (POT1) C-terminal region
POT1 is part of shelterin, a hexameric nucleoprotein complex (comprising TRF1, TRF2, TIN2, RAP1, POT1 and TPP1 in humans) that protects telomeres, the physical ends of chromosomes. Shelterin protects against these ends being recognized as double-stranded DNA breaks, as well as against degradation of the telomeric overhang by endonucleases. It also helps control access of telomerase to the telomeric overhang, thereby affecting telomore length. This C-terminal region has an OB-fold domain and a holiday junction resolvase (HJR) domain which make dimer contacts with TPP1.
Links
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Statistics
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PSSM-Id: 380669
Aligned: 34 rows
Threshold Bit Score: 398.579
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
heterodimerdisease
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:5H65: human POT1C forms a heterodimer with TPP1; contacts at 4A
  • Structure:5UN7: human POT1C forms a heterodimer with TPP1; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    # ####  #      # # ## #                          # #
5H65_A         3 LERTPLCAILKqkaPQQYRIRAKLRSYkPRRLFQSVKLHCPKCHLLQEVPHeGDLDIIFQDGAtktpdvklqntslyDSK 82  human
TKS73840     502 IEPVTLSELKQsnlGRVHHVRAQLRSYkPSRLHQALKLYCSKCTSMQDIPDdELVAHLFSEASkes--------gpcIPP 573 big head croaker
KPP77294     496 LEQVPLSNVKSctpPRLFHVRAQVRSFqPRRLYQALKLRCPHCRALFDIPDdEALASVFQKAIrgv---------rfGSL 566 Asian bonytongue
AWP07917     535 MRPVSLSEVKRsdpGGIHHIRVQLRSYkPHRLHQALKLYCSKCTSMLDIPDdEQVAALFSEASrds--------gpcSPP 606 turbot
XP_005163176 490 TQRITLAQVKRstpPLSCHVRARVKKYlPQQLYQCLKLFCSKCKTMKDVPDdSAVANIFLESArdn---------qpCDE 560 zebrafish
XP_021326184 482 TQRITLAQVKRstpPLSCHVRARVKKYlPQQLYQCLKLFCSKCKTMKDVPDdSAVANIFLESArdn---------qpCDE 552 zebrafish
XP_021326186 364 TQRITLAQVKRstpPLSCHVRARVKKYlPQQLYQCLKLFCSKCKTMKDVPDdSAVANIFLESArdn---------qpCDE 434 zebrafish
RVE71475     526 LQQVTLSELKQsspGQVYHVRAQIRSYePSKLHQALKLFCSKCSSIQDIPDdELLASIFSEACkns--------edcSSP 597 javanese ricefish
XP_015821140 484 IQPMTLSQLKQsqpEGEYHVRAQLRSYqPHRLHQSLKLFCSNCSSMQEIPNeEVLSGIFSAAFqds--------tpcRHP 555 turquoise killi...
XP_020789969 433 LDSVTLSEVKRsnpGQVHHVRVQIKSYqPQKLHQSLKLFCDKCSTMQDLPDeDHVLGLFSAAShdm--------gpcSAP 504 great blue-spot...

Feature 1         ###               #     #        ###              #  ##  ##                    
5H65_A        83 IWTTkn----------qkGRKVAVHFVKnn--gILPLsneCLLLIEGGTLsEICKLSNKFnsVIPVRSghedLELLDLSA 150 human
TKS73840     574 PWLLsgqidapkdnpgslKRALTVHLSTql--mSENRt-kELIFLMGSTLeETRQLVSGYqnIVPVRSsgghLTLLDLSA 650 big head croaker
KPP77294     567 SWAAtgfld-----ssetGRKIAIHLPN-----WDKE---ELIFLEGATLeEVCCISKNLsnIVPVRScgesMVPMDLSV 633 Asian bonytongue
AWP07917     607 PWLLsgwvdipgdspgsqNRALSVHLSAq---lLSEGktkELIFLMGSTLeETSRLAAGYhnIVPVKSsdghLALLDLSA 683 turbot
XP_005163176 561 QWAAtssan-----srepGRTISMHVSKdmvgkSSHM---QLIFIEGMTLdEISVLSRDHknLVPVRSenskMTRMDLTA 632 zebrafish
XP_021326184 553 QWAAtssan-----srepGRTISMHVSKdmvgkSSHM---QLIFIEGMTLdEISVLSRDHknLVPVRSenskMTRMDLTA 624 zebrafish
XP_021326186 435 QWAAtssan-----srepGRTISMHVSKdmvgkSSHM---QLIFIEGMTLdEISVLSRDHknLVPVRSenskMTRMDLTA 506 zebrafish
RVE71475     598 AWALsgsiel---psgstQRAVKVHLSTq---lKAEGkvkELLFIRGTTLeETCRLAKGYknIVPVTAsksgLALMDLSA 671 javanese ricefish
XP_015821140 556 PWILsghvslpedvaqspKKSMDVLASSrllkkENPK---EFIFLQGFSLeETCMLAAHYenIVPLTSsggdLDLLDLSA 632 turquoise killi...
XP_020789969 505 VWALsgqvql--psepagPSDLSLYFSSh---lMSEGknkQLMFLKGASLaQVKTLSASYlnIVPVRStggqLTLLDLSA 579 great blue-spot...

Feature 1                                                            ###              # #        
5H65_A       151 PFLIQGtIHHYGCKQCSSLRsIQNLNSLvdktsWIPSSVAEALGIVPLQYvFVMTFTLDDg--TGVLEAYLMDsDKFFQI 228 human
TKS73840     651 PFLFRGrRKYYGCRRCSEPAlRELCAEGve--lIDETIIAKALGIQLLQYvLLMAFEVQDatdTLEAFLWRDA-KTFFGV 727 big head croaker
KPP77294     634 PFLFQGkKRHYGCRDCSSVRhLEDFTCEed--eWNAKPISEVLGIQPLQYaLLMKMELEDesgFLETLLWDDA-EKFFQV 710 Asian bonytongue
AWP07917     684 PFLFRGrKRFYGCKRCSEAAvREPSAEGvq--vIDEKIVAEALGVQLLQFvLLMKLELQDatdTLNVFLWRDA-ELFLNV 760 turbot
XP_005163176 633 PFLFSGkKRYYGCKQCSRNT-FENPVFTgv-etWDEQAVAAVLGVQMMQYrFLIQFELDDvtdTIEALLWEDA-ERFFHI 709 zebrafish
XP_021326184 625 PFLFSGkKRYYGCKQCSRNT-FENPVFTgv-etWDEQAVAAVLGVQMMQYrFLIQFELDDvtdTIEALLWEDA-ERFFHI 701 zebrafish
XP_021326186 507 PFLFSGkKRYYGCKQCSRNT-FENPVFTgv-etWDEQAVAAVLGVQMMQYrFLIQFELDDvtdTIEALLWEDA-ERFFHI 583 zebrafish
RVE71475     672 PFLFRGpRRYYGCKQCSKATvRELPSQGde--lLDEKIIAEALGVQLLQFvLLLKLQLQDatnTLEVFLWKHA-ELFLGV 748 javanese ricefish
XP_015821140 633 PFLFRGkKRYYGCKRCSEASlRNMKAVGa---vVDEKFLAEDLGIQLLQYvLLMRLKLQDstdTLDVFLWKDA-EKFFGV 708 turquoise killi...
XP_020789969 580 PVLFRGrRRFYGCKKCSNPAvREPSVEGve--eVSGQLVAEALGVELLRYvLLLRLELQDssgSLDVLLWRDA-ELFFNV 656 great blue-spot...

Feature 1            ##  #  #                           # # #       # # #      
5H65_A       229 PASEVLmDDDLQKSVDMIMDMFCPPgikidayPWLECFIKSYNVTng-tdNQICYQIFDTTV 289 human
TKS73840     728 SPEEVAaSQEAENCIHQTMDSLCPPggstgerPWLDLCLMASRTEddggqKQPCYQICHTAF 789 big head croaker
KPP77294     711 TAADVAvSQELQNKIQWTMNRLSER-------PWLELCIAVYTVEeg-grSTVCYQVLNTES 764 Asian bonytongue
AWP07917     761 SAEDAAaNQEAQKSIHQTMDALCPPgdskggrPWLNLCLSAYQAEddegrSQTCYQICQTTV 822 turbot
XP_005163176 710 SAVDASgCQDLQDRIQTIMDTIQPPessleerPWMDFCLSVYTVKdn-drNKVCYQITNTEI 770 zebrafish
XP_021326184 702 SAVDASgCQDLQDRIQTIMDTIQPPessleerPWMDFCLSVYTVKdn-drNKVCYQITNTEI 762 zebrafish
XP_021326186 584 SAVDASgCQDLQDRIQTIMDTIQPPessleerPWMDFCLSVYTVKdn-drNKVCYQITNTEI 644 zebrafish
RVE71475     749 SAEEVAiSQEAQNSVHATLESLCPTegtvgqrPWLDLSLTSYRGAgerdqNQTYYQICSPPV 810 javanese ricefish
XP_015821140 709 SAEDVSaTEEAQERVQKVMDLLCPPedsqdqrPWLDLCLMAYAVEdepgqSQTCYQIINTTI 770 turquoise killifish
XP_020789969 657 SAADAAsSQEAQNHICQTMNSLCPPegskarrPWLDMCLVSYQTKddggsNETVYQICHTTL 718 great blue-spotted mudskipper

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