6LYG


Conserved Protein Domain Family
Ca_hom_mod

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pfam14798: Ca_hom_mod 
Calcium homeostasis modulator
This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.
Statistics
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PSSM-Id: 464320
Aligned: 68 rows
Threshold Bit Score: 176.287
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LYG_B        14 DKFRIMVQFLQANQESFMNGICGIMALASAQMYSSFEFTCPCLPDY--NYAYGIGILIVPPIWFFLLGYVMNNN-ISVLT 90  zebrafish
XP_005043557   2 TFLPKWLTFLKGKEVVIANAIIAILTIGGQQLFSFFTFSCPCHVGQ--NLVYGLAFLGVPALILLIVGYALNNQtWRLVM 79 
XP_001379558   3 DSSFSNILCSLQKSGSFVNTLIAILTICGQQLFSSFTFSCPCQPGN--NLYYGSAFLIIPALVLLVIGYALRSQtWMMTK 80 
Q8CE93         2 SPDLNCISSSLLRSEPCINSLIAILTVCGQQLFSSYTFSCPCQVGK--NFYYGSAFLVVPALILLIAGYALRGQmWTVAS 79  house mouse
XP_003781659   5 LHSIVSSLQRSGTFINSLIAALTICGQQAFSSFTFRCPCQVGKNFL--YGSAFLVMPALILLVAGYALRRQMWTiTGEHC 82 
XP_698380      7 EYFKCIAIYIKNKDATILNTVIGLGTVVGQTAYNILAFNCPCSPKK--NYLYGLAAIGVPALAFFVIGVMMNQNtWDVVS 84 
5_pfamImport   2 DKFRMVFQFLQSNQESFMNGICGIMALASAQIYSAFDFNCPCLPGY--NTAYSAGILLAPPLVLFLLGLVLNNNvSMLVA 79 
EFP07397       7 SVVTVFQNVFTNHGSTLLNGILIATTIGGQSLVRKLTFSCPC--AYplNMYHSLVFIFGPTAALLLIGITINSTtWKLAH 84 
XP_009858565   3 TIFAAFGKTVGNNKGSIQNFGIVGVTIATEEIAKFIFFYCPC--DYpaNKIYGSVFIWGPAFVLLLAGFLVNRRtWRLTT 80  vase tunicate
XP_018549573   9 ENFKFVSLFFKSKDVMIFNGLIALGTVASQTAYNVFAFDCPCSSGR--NYLYGLAAIGVPALAFFLIGIMLNNStWDLVS 86  barramundi perch
6LYG_B        91 EEwK-------RPVGKRSkdpAVL---RYMFSSMTQRALIAPAVWIAVTLMDGKSFLCA--FSptADLSEFVNe-----S 153 zebrafish
XP_005043557  80 GKrShfg-rvtPSNWWLKcklVCF-----VLCSITGRALVAPVTWLAVTLINGSYYICA--VSeyVPVYYYGA------- 144
XP_001379558  81 EScCsss-phlRSVNSLQrklACL-----MFFSITGRALVAPLTWLAVTLLTGTYYECA--ASeyASVEQYSM------- 145
Q8CE93        80 EYcCcsctppyRRSSPLErrlACL-----MFFDITGRALVAPLTWLTVTLLTGTYYECA--ASefASVDQYPM------- 145 house mouse
XP_003781659  83 CS-CapgrrrlSPLERRLaclGCF-----GITGRAVVAPLAWLAATLLTGTYYECAASQ--FAsvDHYPEFAN------- 147
XP_698380     85 ECrT-------RRCRKLSltaAFV-----LLGSIVGRAIAAPITWTVISLLRGEAYVCA--FSefLNFSSLVNft--saS 148
5_pfamImport  80 DIeE-------ERNRNPRlppTFL-----LLSSILGRAAVAPITW-VISLLRGEAYVCA--LSefVDPSSLTA------- 137
EFP07397      85 GFfF-------RVRDTRHswkTTC----ASWIEVLLQSSIAPIAWLFVVFLDGGYYRCYrsHEfcLTADAILCknetvwN 153
XP_009858565  81 GL-C-------NRTNGVGkggKRIfhfLFIFFQIFVKAFIAPATWLILAFLKGDYYACAr----wPNPEDYQArarhhlK 148 vase tunicate
XP_018549573  87 ECrL-------RKCWKLSgatAFA-----LVGTIIGRAVVAPLTWVVISLLQGQAYTCA--LSefVDPSTL--------- 143 barramundi perch
6LYG_B       154 YQSLsqke-llkIQAKI--------PCKDIFEEHEIIsr--eaATRYIRCLSQACGWTFLMVITLVAFLVRAIRPCFTQA 222 zebrafish
XP_005043557 145 APNVtase-rsrILATF--------PCSQLVPPELTRar--deVILLLRYQSQVAGWLLIAVVVITVFLSYCLASCFSPL 213
XP_001379558 146 FNNYsepe-rqeILAEF--------PCFEQISPDMLMvr--deVALQLRYQSQMWGWTLIAVATLVAFLSCCLARCCSPL 214
Q8CE93       146 FANVtpsk-reeMLAGF--------PCYTSAPSDVIPir--deVALLHRYQSQMLGWILVVLATIALLLSKCLARCCSPL 214 house mouse
XP_003781659 148 FSASeree-ilaGFPCS--------TPPPSDLLPVRDei--vlLHRYQSQMLGWILITLATITILVSSCLARCCSPLTSL 216
XP_698380    149 PGPE--------IMARF--------PCNS-TPVLFINyt--gvVQRQLKYESQLLGWLLVGLISLSVFLVLCLKTCFSPL 209
5_pfamImport 138 GGEGfprdhateILARF--------PCGE-GPANLSGfr--eeVSRRLKYESQLFGWLLIGVVAVLVFLTKCLKHYCSPL 206
EFP07397     154 SYATs------tSFNRIsdngkycpPCICFPNPT---------DASYLEAESQIYAWALLVVAGVGAFLVITCHRMCDKY 218
XP_009858565 149 ASND--------SLPR---------PCMFNPNPIKFDgseaeiIARNLRAESHTIGWFYVCFGMSIGIVLVLIFRCRSKY 211 vase tunicate
XP_018549573 144 --EDfpsgqeleVMAKF--------PCQGSVPMELQGfw--aeIERRLKYESQLIGWLLVAGMSLMVFLMLCMKRCYSPL 211 barramundi perch
6LYG_B       223 AFLKTKYWSHYIDTERKLFDETCKEHAKSFAKVCIQQYFESISG 266 zebrafish
XP_005043557 214 SFLHFRYWSSYVHNEQELFDEATDQHSRLYAMQNVRKFFGFFPG 257
XP_001379558 215 TSLQHQYWCTHMRNERQLFEEAAEQHSRVLITQRIKELFGFVPG 258
Q8CE93       215 TSLQHHYWTNHLHNERVLFEKAAEEHSQLLIRHRIKKVFGFVPG 258 house mouse
XP_003781659 217 QDYYWNNHLQNERQLFEEAAEQHSRLLITQRIKKLFGFVPGSQD 260
XP_698380    210 GYHQEAYWSEYCASERALFQRTAEVHAKYHAAENVKSFFGFVAL 253
5_pfamImport 207 SYRQEAYWTQYRNNEEQLFQRTAEVHSRVLAANNVRRFFGFVAL 250
EFP07397     219 TLVQRQYVETYKNVETQKFDAVAKEHASQLAEHNARAFFGQKDW 262
XP_009858565 212 SYEQSNYIDRYRQSEIQQFEDELDKKAAEQAKRIVDGYFSKPRS 255 vase tunicate
XP_018549573 212 GYQQEDYWSQYRSNEKILFQRTATVHARLLAAENIKSFFGFVAL 255 barramundi perch
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