1L8L,1NNL,3KD3


Conserved Protein Domain Family
HAD_PSP_eu

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cd04309: HAD_PSP_eu 
Click on image for an interactive view with Cn3D
phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase
Human PSP, EC 3.1.3.3, catalyzes the third and final of the L-serine biosynthesis pathway, the Mg2+-dependent hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, L-serine is a precursor for the biosynthesis of glycine. HPSP regulates the levels of glycine and D-serine (converted from L-serine), the putative co-agonists for the glycine site of the NMDA receptor in the brain. Plant 3-PSP catalyzes the conversion of 3-phosphoserine to serine in the last step of the plastidic pathway of serine biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319801
Aligned: 14 rows
Threshold Bit Score: 257.981
Created: 28-Apr-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #####    #                                                                 
1L8L_A        15 DAVCFDVDSTVIreEGIDELAKICGVEdavsemTRRAMGGavpFKAALTERLALIQPsrEQVQRLIAeqp--phLTPGIR 92  human
BAA33807      84 EAVCFDVDSTVCvdEGIDELAEFCGAGkavaewTARAMGGsvpFEEALAARLSLFKPslSKVEEYLDkrp--prLSPGIE 161 thale cress
AAC46897       9 KCVCLDVDSTVCedEGLDEIASYIGVTdrvkkiTDEAMNGeldINKALEARLSIMNLnvKKLTDFLDnhp--vrLTPGVE 86  Schistosoma man...
NP_524001     62 QIVCFDVDSTVIceEGIDELAEYCGKGsevarvTKEAMGGamtFQDALKIRLNIIRPtqQQVRDFIQerp--stLSKNVK 139 fruit fly
NP_001028271  15 DAVCFDVDSTVIreEGIDELAKFCGVGdavtemTRKAMGGsmsFQTALSERLSIIKCsrEQVNKLITdhp--pqLTPGIR 92  zebrafish
BAF36819      15 DCVCFDVDSTVIqdEGIDEMARFCGKGeevkrlTAEAMGGsmtFQEALKKRLDIIRPtvSQIRQFVAthp--vrLTPGVE 92  diamondback moth
EDS45712      99 QIVCFDVDSTIIteEGIDELAQYCGKGsevaalTKEAMGGsmtFQEALRRRLDIIKPsqRQIREFLKthp--stISGGVR 176 southern house ...
NP_502580     54 DAVCFDVDSTVCqdEGIDELAAYLGVGeavanvTRTAMNGnarFRDALAARLQVMKPnhEQLEQFVNisk--pkLTVGIR 131 nematode
ABI13185      87 DAICFDVDATVIreEGINRLATHNGCGeqieamTVRTMEGdtpFHEALRERLDIIRPsqSDVASLIAqnakdelLSPGVA 166 Emiliania huxleyi
AAX56341     111 DAVCFDVDRTVTtdASVGLLAKFMGIEdeaqslTEQANRGeinLTKAFEDRLAKLNFtpTDIDRFLEehpahtrLVPGVE 190 Dunaliella salina
Feature 1                        ##                                                        #     
1L8L_A        93 ELVSRLQerNVQVFLISGGFRSIVEHVASKLNIpaTNVFANRLKFYf-----nGEYAGFDEtqpt----aesGGKGKVIK 163 human
BAA33807     162 ELVKKLRanNIDVYLISGGFRQMINPVASILGIprENIFANNLLFGn-----sGEFLGFDEnept----srsGGKAKAVQ 232 thale cress
AAC46897      87 NLVNQFKenGIDVYLVSGGLYPLVSRVAELLNIpeENVYANKLIFNn-----eGTYVGLDHnapt----srsDGKALIVN 157 Schistosoma man...
NP_524001    140 RFVSHLKaeGKQVYLISGGFDCLIAPVANELGIplKNVYANKMLFDy-----lGEYDSFDInqpt----srsGGKAEAIA 210 fruit fly
NP_001028271  93 ELVQKLQqrGVQVFLVSGGFRCIVEHVASQLSIplQHVYANRLKFYf-----nGEYAGFDEsqpt----aqsGGKGRVIS 163 zebrafish
BAF36819      93 QLVKSLHerGVTVYLVSGGFRCLIEPVAEILGIplTNIYANRLKFFf-----nGEYAGFDDtept----srsGGKGLVIR 163 diamondback moth
EDS45712     177 ELIDQLRrnSAEIYLVSGGFDCLIEPVADALEIplCNLFANKLYFHf-----nGSYAGFDTnqvt----sksGGKGEAIK 247 southern house ...
NP_502580    132 ELVSRLHarGTHVYLVSGGFRRLILPVAELLGIekSRIYANEILFDk-----fGKYHGFDTseltsdsgskeTGKPAVIA 206 nematode
ABI13185     167 DLVRSLHesGRPVFLLSGGFRQIINPFAAQLGVeeSHVYANTLLFDe-----qGDYSGVDPtelt----sqpSGKARVIS 237 Emiliania huxleyi
AAX56341     191 NLIAALKarGVEVFLISGGFREMALPIASHLKIpaKNVFCNTMSWQlddhgepVRLQGLDMtra-----aesHFKSRAIE 265 Dunaliella salina
Feature 1                       ##  ##                                        
1L8L_A       164 FLKEKfhf-kkIIMIGDGATDMEACPPA-------DAFIGFGGNVirQQVKDNAkWYITDF 216 human
BAA33807     233 QIRKGrly-ktMAMIGDGATDLEARKPGg-----aDLFISYAGVQlrEAVAANAdWLIFKF 287 thale cress
AAC46897     158 ELLNKlh--tpVMMIGDGMTDAKACPPA-------SVFIGFGVNVirPKVKAISdYFCTSV 209 Schistosoma mansoni
NP_524001    211 LIRKEnsddslITMIGDGATDLEAVPPA-------NYFIGFGGNVvrPEVYRRAqYYVTDF 264 fruit fly
NP_001028271 164 MLKEKhgf-qnILMIGDGATDLEACPPA-------SAFIGFGGNVlrPQVKEKSsWYVSSF 216 zebrafish
BAF36819     164 RLKEQhsy-qrVIMIGDGATDAEASPPA-------EGFIGFGGNVmrEEVKKRAsWYVTDF 216 diamondback moth
EDS45712     248 QIKGRfnsnkvVAMIGDGMTDLEACPPA-------DLFIGYGGNAvrEEVQKRAtYYVTNF 301 southern house mosquito
NP_502580    207 LLKKMyny-ktVVMVGDGATDVEASPPA-------DAFIGFGGNVirEGVKARAkWYVTDF 259 nematode
ABI13185     238 MLKEThgf-ekVVMIGDGANDMSARDCPdhaangaDVFIGFGGVKvrETVRQGAdWFVTDF 297 Emiliania huxleyi
AAX56341     266 RIRRKypy-nnIIMVGDGFSDLEAMQGSpd---gaDAFICFGGVMqrPAVASQAdWFVRSY 322 Dunaliella salina

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