1R9O,5X24,4GQS,1PQ2,1PQ2,1DT6,3E4E


Conserved Protein Domain Family
CYP2C-like

?
cd20665: CYP2C-like 
Click on image for an interactive view with Cn3D
cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
This CYP2C-like group includes CYP2C, and similar CYPs including mammalian CYP2E1, also called 4-nitrophenol 2-hydroxylase, as well as chicken CYP2H1 and CYP2H2. The CYP2C subfamily is composed of four human members (CYP2C8, CYP2C9, CYP2C18, CYP2C19) that metabolize approximately 20% of clinically used drugs, and all four exhibit genetic polymorphisms that results in toxicity or altered efficacy of some drugs in affected individuals. CYP2E1 participates in the metabolism of endogenous substrates, including acetone and fatty acids, and exogenous compounds such as anesthetics, ethanol, nicotine, acetaminophen, aspartame, and chlorzoxazone, among others. The CYP2C-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
?
PSSM-Id: 410758
Aligned: 46 rows
Threshold Bit Score: 770.276
Created: 1-Apr-2019
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:1R9O: Human cytochrome P450 2C9 binds heme; contacts at 4A
  • Structure:1PQ2: Human cytochrome P450 2C8 binds heme; contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #              ##      #   #                
1R9O_A     44 YGPVFTLYfglkPIVVLHgYEAVKEALIDLGEEFSGRGIFPlaeranRGFGIVFSNGKKWKEIRRFSLMTLRNFgmgkrs 123 human
3E4E_A     43 FGPVFTLYvgsqRMVVMHgYKAVKEALLDYKDEFSGRGDLPafh-ahRDRGIIFNNGPTWKDIRRFSLTTLRNYgmgkqg 121 human
AAH77850   63 YGPVSMVFlgqnPVLVLNgYDVVKEAFVENGEVFSNRGKNTfiemlfKGRGVAFSNGETWRQMRRFSLSTLRDFgmgkrs 142 African clawed frog
P24470     65 YGPVYTLYfgtsPTVVLHgYDVVKEALLQQGDEFLGRGPLPiiedthKGYGLIFSNGERWKVMRRFSLMTLRNFgmgkrs 144 Norway rat
P20678     64 YGPIFTIHlgpkKVVVLYgYDVVKEALIDNGEAFSGRGNLPlfekvfKGTGIVTSNGESWRQMRRFALTTLRDFgmgkks 143 chicken
AAH60328   65 YGPMYTLYlgghPLVMLIgYDAVKEALIDYGDVFSDRGRTGisqaifSEYGVIMSNGERWKTMRRFTLMTLRNFgmgkrs 144 African clawed frog
P05181     64 FGPVFTLYvgsqRMVVMHgYKAVKEALLDYKDEFSGRGDLPafh-ahRDRGIIFNNGPTWKDIRRFSLTTLRNYgmgkqg 142 human
Q29510     61 YGPVFTVYfgtkPSVVLHgYEAVKEALVDHGEEFSGRVTVPvfdryaQGAGLFASQGELWKETRRFTLTVLRNMgmgkkt 140 rabbit
O18963     64 YGPVFTLYlgsqRAVVVHgYKPVKEVLLDYKNEFSGRGENPgfq-mhKNNGIIFNNGSTWRDTRRFSLTTLRDLgmgkqg 142 cattle
Q91W64     61 YGPVFTVYlgmkPTVVLHgYKAMKEALIDQGDEFSDKTDSSllsrtsQGLGIVFSNGETWKQTRRFSLMVLRSMgmgkkt 140 house mouse
Feature 1                                                                                     
1R9O_A    124 iEDRVQEEARCLVEELRKTkaspcdPTFILGCAPCNVICSIIFHKRFDYkdQQFLNLMEKLNENIKILSSPWIQicnnfs 203 human
3E4E_A    122 nESRIQREAHFLLEALRKTqgqpfdPTFLIGCAPCNVIADILFRKHFDYndEKFLRLMYLFNENFHLLSTPWLQlynnfp 201 human
AAH77850  143 iEERVQEEACSLVEEFNKTkgapfdSTYLLTLAVSNVICSIVFGNRFEYknETFLSVLALLKDTFRIVTSPWTQffgfap 222 African clawed frog
P24470    145 lEERVQEEARCLVEELQKTkaqpfdPTFILACAPCNVICSILFNDRFQYndKTFLNLMDLLNKNFQQVNSVWCQmynlwp 224 Norway rat
P20678    144 iEERIQEEARFLVERIRNThekpfnPTVFLMHAVSNIICSTVFGDRFDYedKKFLDLIEMLDENERYQNRIQTQlynffp 223 chicken
AAH60328  145 lEERIQEEARNLEEAFRKKrdepfdPIYLLGLAVSNIICSIIFGERFDYedEKFKSLLMYMRETLKLLNSFLGQvlnlfp 224 African clawed frog
P05181    143 nESRIQREAHFLLEALRKTqgqpfdPTFLIGCAPCNVIADILFRKHFDYndEKFLRLMYLFNENFHLLSTPWLQlynnfp 222 human
Q29510    141 iEDRIQEEASCLVKALKETnaspcdPSSLLFCVPCNVICSIIFQNRFEYndQTFQTLVKHFLDSIRLFNTPWMQlyntfp 220 rabbit
O18963    143 nEQRIQREAHFLLEVLRKTqgqpfdPTFVVGFAPYNVISDILFHKRFDYkdQTSLRLMSLFNENFYLLSSPWIQlynnfp 222 cattle
Q91W64    141 iEDRIQEEILYMLDALRKTngspcdPSFLLACVPCNVISTVIFQHRFDYndQTFQDFMENFHRKIEILASPWSQlcsayp 220 house mouse
Feature 1                                                                              #  ##  
1R9O_A    204 piidyfPGTHNKLLKNVAFMKSYILEKVKEHqesmdmnnpQDFIDCFLMKMekekhnqpsefTIESLENTAVDLFGAGTE 283 human
3E4E_A    202 sflhylPGSHRKVIKNVAEVKEYVSERVKEHhqsldpncpRDLTDCLLVEMekekhsaerlyTMDGITVTVADLFFAGTE 281 human
AAH77850  223 gflqhfPGPHKMAAKNIGRLKKFVTEIVTTHeetldenspRDYIDCFLIKMrqekgnvntefDYENLFVTLLNLFFAGTE 302 African clawed frog
P24470    225 tiikylPGKHIEFAKRIDDVKNFILEKVKEHqksldpanpRDYIDCFLSKIeeekdnlksefHLENLAVCGSNLFTAGTE 304 Norway rat
P20678    224 tildylPGPHKTLIKSIETVDDFITEIIRAHqesfdascpRDFIDAFINKMqqeke--nsyfTVESLTRTTLDLFLAGTG 301 chicken
AAH60328  225 nlslyiPGPHQKVFANFNKLKEFVKDEAKSHrdtldancpRDFIDCFLIRMeeekinpdtefHNENLFAVIFDLFFAGTE 304 African clawed frog
P05181    223 sflhylPGSHRKVIKNVAEVKEYVSERVKEHhqsldpncpRDLTDCLLVEMekekhsaerlyTMDGITVTVADLFFAGTE 302 human
Q29510    221 -ilhylPGSHHELFKVFNDQMKFFSEKIREHqesldhnnpRDFIDYLLIKMekekhnkqsqfTMHHLLVTIWDVFDAGSQ 299 rabbit
O18963    223 dylqylPGSHRKLLKNVSEVKSYALERVKDHqkslepscpRGFLDTMLIEMakerhsvdpmyTLENIAVTVADLLFAGTE 302 cattle
Q91W64    221 -ilyylPGIHNRFLKDVTQQKKFILEEINRHqksldlsnpQDFIDYFLIKMekekhnqksefTMDNLVVSIGDLFGAGTE 299 house mouse
Feature 1     ##  #                                                  #    ##  ## #            
1R9O_A    284 TTSTTLRYALLLLLKHPEVTAKVQEEIERvigrnrspcmqdrshMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 363 human
3E4E_A    282 TTSTTLRYGLLILMKYPEIEEKLHEEIDRvigpsripaikdrqeMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 361 human
AAH77850  303 TTSITLRYGMLLLLKYPDIQKKIHDEIDCvvglnrcpsmedrpkLPYTDATIHEIQRFADIVPMGVPRSTNKDTTLRGYD 382 African clawed frog
P24470    305 TTSTTLRFGLLLLMKYPEVQAKVHEELDRvigrhqppsmkdkmkLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRDYV 384 Norway rat
P20678    302 TTSTTLRYGLLILLKHPEIEEKMHKEIDRvvgrdrspcmadrsqLPYTDAVIHEIQRFIDFLPVNLPRAVIKDTKLRDYF 381 chicken
AAH60328  305 TSSLTLRYAFLILQKYPEIQEKVYKEIDEvigqhrypsvedrskMPYTEAVIHEIQRFADIIPSGLERSASKDTTFRGYY 384 African clawed frog
P05181    303 TTSTTLRYGLLILMKYPEIEEKLHEEIDRvigpsripaikdrqeMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 human
Q29510    300 TTSSTMQFGLLLLMKHPEIAAKVQEEIERvigrdrspcmqdrscMPYTDAVIHEIQRYIDMVPNNVPHAVTQDIQFRGYL 379 rabbit
O18963    303 TTSTTLRYGLLILMKYPEVEEKLHEEIDRvigpsripavkdrldMPYLDAVVHEIQRFIDLLPSNLLHEATQDTVFRGYV 382 cattle
Q91W64    300 TTSSTVKYGLLLLLKYPEVTAKIQEEIAHvigrhrrptmqdrnhMPYTDAVLHEIQRYIDFVPIPSPRKTTQDVEFRGYH 379 house mouse
Feature 1                                                   ###   # ###   #  #                
1R9O_A    364 IPKGTTILISLTSVLhDNKEFpNPEMFDPHHFldeggnFKKSKyfMPFSAGKRICVGEALAGMELFLFLTSILQNFNlks 443 human
3E4E_A    362 IPKGTVVVPTLDSVLyDNQEFpDPEKFKPEHFlnengkFKYSDyfKPFSTGKRVCAGEGLARMELFLLLCAILQHFNlkp 441 human
AAH77850  383 IPKGTTVFPMLTSIMkDPRYFkDPESFNPCHFldekgsLKKSDafLPFSIGKRVCLGEGLARMEIFLFLTSILQRFElkc 462 African clawed frog
P24470    385 IPKGTTVLPMLSSVMlDQKEFaNPEKFDPGHFldkngcFKKTDyfVPFSLGKRACVGESLARMELFLFFTTLLQKFSlkt 464 Norway rat
P20678    382 IPKDTMIFPLLSPILqDCKEFpNPEKFDPGHFlnangtFRKSNyfMPFSAGKRICAGEGLARMELFLFLTSILQNFSlkp 461 chicken
AAH60328  385 IPKGTSVFPVLTSVLkDPKYFkNPDQFDPRHFldengcFKKNEafMPFSTGKRMCAGEGLARMEIFIFLTTILQKFIlkp 464 African clawed frog
P05181    383 IPKGTVVVPTLDSVLyDNQEFpDPEKFKPEHFlnengkFKYSDyfKPFSTGKRVCAGEGLARMELFLLLCAILQHFNlkp 462 human
Q29510    380 IPKGTHILPSLTSVLyDEKEFpNPEKFDPGHFldasgnFKKSDyfLPFSIGKRACAGEGLARMELFLVLTTILQHFTlkp 459 rabbit
O18963    383 IPKGTVVIPTLDSVLhDRQEFpEPEKFKPEHFlnengkFKYSDhfKAFSAGKRVCVGEGLARMELFLLLAAILQHFNlks 462 cattle
Q91W64    380 IPKGTSVMACLTSVLnDDKEFpNPEKFDPGHFldekgnFKKSDyfVAFSAGRRACIGEGLARMEMFLILTNILQHFTlkp 459 house mouse
Feature 1                              
1R9O_A    444 lvdPKNLDTTPVVngFASVPPFYQL 468 human
3E4E_A    442 lvdPKDIDLSPIHigFGCIPPRYKL 466 human
AAH77850  463 hmdPEDIDISPVPfkAASTPRPYEL 487 African clawed frog
P24470    465 lvePKDLDIKPITtgIINLPPPYKL 489 Norway rat
P20678    462 vkdRKDIDISPIVtsAANIPRPYEV 486 chicken
AAH60328  465 tvdTEAIKITPQPntNASRPWPYKM 489 African clawed frog
P05181    463 lvdPKDIDLSPIHigFGCIPPRYKL 487 human
Q29510    460 lvdPKDIDPTPVDngFLSVPPSYEL 484 rabbit
O18963    463 lvdPKDIDLSPIAigFGKIPPRYKL 487 cattle
Q91W64    460 lvkPEDIDTKPVQtgLLHVPPPFEL 484 house mouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap