1QVA,3EIQ,1QDE,2G9N,1FUU,3BOR,2ZU6,2VSO


Conserved Protein Domain Family
DEADc_EIF4AII_EIF4AI_DDX2
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cd18046: DEADc_EIF4AII_EIF4AI_DDX2 
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DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II
Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350804
Aligned: 16 rows
Threshold Bit Score: 360.608
Created: 10-Aug-2017
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2VSO; Saccharomyces cerevisiae eIF4A-eIF4G complex with bound ATP, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #                 # #    #                  #######                             
1QVA_A     23 FDDMELDEQLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIdtsvkapQALMLAPTRELA 102 baker's yeast
1QDE_A     16 FDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIdtsvkapQALMLAPTRELA 95  baker's yeast
1FUU_A     23 FDDXELDENLLRGVFGYGFEEPSAIQQRAIXPIIEGHDVLAQAQSGTGKTGTFSIAALQRIdtsvkapQALXLAPTRELA 102 baker's yeast
2VSO_A     24 FDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIdtsvkapQALMLAPTRELA 103 baker's yeast
124217     31 FDDMELKEELLRGIYGFGFEKPSAIQKRAIVPCTTGKDVIAQAQSGTGKTATFSVSILQRIdhedphvQALVMAPTRELA 110 Caenorhabditis ele...
Q7RV88     26 FDEMNLKPELLRGIYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKIdpslkacQALILAPTRELA 105 Neurospora crassa ...
Q02748     32 FDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIdtsirecQALILAPTRELA 111 fruit fly
O02494     33 FEALNLEGDLLRGIFAYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQKIdyslnacQVLLLAPTRELA 112 Cryptosporidium pa...
Q8JFP1     35 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLeidlketQALVLAPTRELA 114 chicken
NP_938180  34 FDDMNLREALLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIdvelkatQAMVLAPTRELA 113 zebrafish

Feature 1                                                                                     
1QVA_A    103 LQIQKVVMALAfhmdIKVHACIGGtsfVEDAEGLR--DAQIVVGTPGRVFDNIQRrrfRTDKIKMFILDEADEMLsSGFK 180 baker's yeast
1QDE_A     96 LQIQKVVMALAfhmdIKVHACIGGtsfVEDAEGLR--DAQIVVGTPGRVFDNIQRrrfRTDKIKMFILDEADEMLsSGFK 173 baker's yeast
1FUU_A    103 LQIQKVVXALAfhxdIKVHACIGGtsfVEDAEGLR--DAQIVVGTPGRVFDNIQRrrfRTDKIKXFILDEADEXLsSGFK 180 baker's yeast
2VSO_A    104 LQIQKVVMALAfhmdIKVHACIGGtsfVEDAEGLR--DAQIVVGTPGRVFDNIQRrrfRTDKIKMFILDEADEMLsSGFK 181 baker's yeast
124217    111 QQIQKVMSALGeylnVNILPCIGGtsvRDDQRKLEa-GIHVVVGTPGRVGDMINRnalDTSRIKMFVLDEADEMLsRGFK 189 Caenorhabditis ele...
Q7RV88    106 QQIQKVVVAIGdfmnIECHACIGGtsvRDDMKALQd-GPQVVVGTPGRVHDMIQRrflKTDSMKMFVLDEADEMLsRGFT 184 Neurospora crassa ...
Q02748    112 TQIQRVVMALGeymkVHSHACIGGtnvREDARILEs-GCHVVVGTPGRVYDMINRkvlRTQYIKLFVLDEADEMLsRGFK 190 fruit fly
O02494    113 QQIQKVALALGdyceLRCHACVGGtsvRDDMNKLKs-GVHMVVGTPGRVFDMLDKgylRVDNLKLFILDEADEMLsRGFK 191 Cryptosporidium pa...
Q8JFP1    115 QQIQKVILALGdymgATCHACIGGtnvRNEMQKLQaeAPHIVVGTPGRVFDMLNRrylSPKWIKMFVLDEADEMLsRGFK 194 chicken
NP_938180 114 QQIQKVVLALGdymgATCHACIGGtnvRNDVQKLQadVPHIVVGTPGRVFDMLNRrylSPKYIKMFALDEADEMLsRGFK 193 zebrafish

Feature 1                                               
1QVA_A    181 EQIYQIFTLLPpTTQVVLLSATMPNDVLEVTTKFMRNPVRIL 222 baker's yeast
1QDE_A    174 EQIYQIFTLLPpTTQVVLLSATMPNDVLEVTTKFMRNPVRIL 215 baker's yeast
1FUU_A    181 EQIYQIFTLLPpTTQVVLLSATXPNDVLEVTTKFXRNPVRIL 222 baker's yeast
2VSO_A    182 EQIYQIFTLLPpTTQVVLLSATMPNDVLEVTTKFMRNPVRIL 223 baker's yeast
124217    190 DQIYEVFRSMPqDVQVVLLSATMPSEVLDVTNRFMRNPIRIL 231 Caenorhabditis elegans
Q7RV88    185 EQIYDIFQLLPqSTQVVLLSATMPQDVLEVTTKFMREPVRIL 226 Neurospora crassa OR74A
Q02748    191 DQIQDVFKMLPpDVQVILLSATMPPDVLEVSRCFMRDPVSIL 232 fruit fly
O02494    192 VQIHDIFKKLPqDVQVALFSATMPNEILHLTTQFMRDPKRIL 233 Cryptosporidium parvum
Q8JFP1    195 DQIYEIFQKLStNIQVVLLSATMPMDVLEVTKKFMREPIRIL 236 chicken
NP_938180 194 DQIYEIFQKLAtDTQVILLSATMPQEVLEVTTKFMRDPVRIL 235 zebrafish

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