2A3S


Conserved Protein Domain Family
FH_FOXK1
?
cd20054: FH_FOXK1 
Click on image for an interactive view with Cn3D
Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins
FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
?
Statistics
?
PSSM-Id: 410828
Aligned: 7 rows
Threshold Bit Score: 192.735
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens FOXK2 (2C6Y) binds DNA through its Forkhead domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  ###                 ##  #              #   ## ##  ##     #       # ### #   
2A3S_A         1 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80  house mouse
P85037       303 ESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 382 human
AAF97842       8 ESKPPYSYAQLIVQAISSAPDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 87  chicken
NP_956196    256 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRVD 335 zebrafish
XP_007901669 218 DSKPPYSYAQLIVQAISSAQDKQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKMPRSQEEPGKGSFWRID 297 elephant shark
XP_006010297 253 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 332 coelacanth
AUR44902     189 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 268 Chinese giant s...

Feature 1                      #  #   
2A3S_A        81 PASEAKLVEQAFRKRRQRGVS 101 house mouse
P85037       383 PASEAKLVEQAFRKRRQRGVS 403 human
AAF97842      88 PASEAKLVEQAFRKRRQRGVS 108 chicken
NP_956196    336 PSSEAKLVEQAFRKRRQRGVS 356 zebrafish
XP_007901669 298 PSSEAKLVEQAFRKRRQRGVS 318 elephant shark
XP_006010297 333 PASEAKLVEQAFRKRRQRGVS 353 coelacanth
AUR44902     269 PASEAKLVEQAFRKRRQRGVS 289 Chinese giant salamander

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap