2H03,2AHS


Conserved Protein Domain Family
R-PTPc-B
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cd14617: R-PTPc-B 
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catalytic domain of receptor-type tyrosine-protein phosphatase B
Receptor-type tyrosine-protein phosphatase B (PTPRB), also known as receptor-type tyrosine-protein phosphatase beta (R-PTP-beta) or vascular endothelial protein tyrosine phosphatase(VE-PTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRB/VE-PTP is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is expressed specifically in vascular endothelial cells and it plays an important role in blood vessel remodeling and angiogenesis.
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Statistics
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PSSM-Id: 350465
Aligned: 6 rows
Threshold Bit Score: 503.682
Created: 13-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 12 residue positions
Conserved feature residue pattern:x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on binding to inhibitors
  • Structure:2H03: Human R-PTP-beta binds non-peptidic inhibitor; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # #                                                                           
2H03_A         57 NRYNNILPYDATRVKls-----ggSDYINASYIPGNnfrrEYIVTQGPlpgtkDDFWKMVWEQnvHNIVMVTQCvekgrV 131  human
2AHS_A         55 NRYNNILPYDATRVKlsnvdddpcSDYINASYIPGNnfrrEYIVTQGPlpgtkDDFWKMVWEQnvHNIVMVTQCvekgrV 134  human
XP_006121625 1944 NRYNNILPYDTSRVKlsnvdddpcSDYINASYIPGNnfrrEYIATQGPlpgtkDDFWKMAWEQnvHNIVMVTQCvekgrV 2023 Chinese soft-...
NP_001303656 1638 NRYNNILPYDSTRVRlscleddpcSDYINANYIPGNnfrwEYIATQGPlpgtkDDFWRMVWEQnvHSLVMVTQCvergmV 1717 zebrafish
NP_001131088 2060 NRYSNILPYDSTRVKlanvdddpcSDYINASYMPGInfrrEYIATQGPlpatkDDFWKMVWEQnvHIIVMVTQCtergrA 2139 tropical claw...
XP_007901984 1953 NRYNNILPYDPTRVKlsyidddpcSDYINASYIPGCsfrrEYIATQGPlpgtkDDFWKMAWEQniHNIVMVTQCvekgrV 2032 elephant shark

Feature 1                                                                    ##                   
2H03_A        132 KCDHYWPADqdslyyGDLILQMLSESVLpeWTIREFKICGEEQLdahRLIRHFHYTVWPDHGVPetTQSLIQFVRTVRDY 211  human
2AHS_A        135 KCDHYWPADqdslyyGDLILQMLSESVLpeWTIREFKICGEEQLdahRLIRHFHYTVWPDHGVPetTQSLIQFVRTVRDY 214  human
XP_006121625 2024 KCDHYWPLDrdslyyGDLIVEMLSESVLpeWTIREFKICSEEQLdskRLIRHFHYTVWPDHGVPetTQSLIQFVRTVRDY 2103 Chinese soft-...
NP_001303656 1718 KCDHYWPTDseplcyGDIVVQLLSEKVFpeWTIRDFKISCESQLrypRMVRQFHYTIWPDHGVPdtTQSLIQFVRTVRDF 1797 zebrafish
NP_001131088 2140 KCDHYWPMDqdsyyyGDLIVQMLSESVLpeWTIREFKICSEDQIdapRLVRHFHYTVWPDHGVPetTQSLIQFVRTVRDY 2219 tropical claw...
XP_007901984 2033 KCDHYWPFDhdalyyGDLIVQLLSESVLpeWTIREFKICNEDQLdcaRIVRHFHYTVWPDHGVPetTQSLIQFVKTVRDY 2112 elephant shark

Feature 1                      #######                                     #          
2H03_A        212 INrspgaGPTVVHCSAGVGRTGTFIALDRILQQLdskdsvDIYGAVHDLRLHRVHMVQTECQYVYLHQ 279  human
2AHS_A        215 INrspgaGPTVVHCSAGVGRTGTFIALDRILQQLdskdsvDIYGAVHDLRLHRVHMVQTECQYVYLHQ 282  human
XP_006121625 2104 VNrtpdtGPTIVHCSAGVGRTGTFIALDRILQQLdskdsvDIYGAVHDLRLHRVHMVQTECQYVYLHQ 2171 Chinese soft-shelled turtle
NP_001303656 1798 INrtnspGISVVHCSAGVGRTGTFIVLDRALQQLdrnctvDIYGCVFDLRLHRSYMVQTECQYAYIHQ 1865 zebrafish
NP_001131088 2220 INrtpgsGPTVVHCSAGVGRTGTFIVLDRMLQQVdtvdsvDIFGAVRDLRIHRMYMVQTECQYVYLYQ 2287 tropical clawed frog
XP_007901984 2113 INrspnsGPTVVHCSAGVGRTGTFIALDRVLQQLeskdsvDIYGTLYDLRLHRVHMVQTECQYSYLHL 2180 elephant shark

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