2DKZ


Conserved Protein Domain Family
SAM_GAREM
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cd09525: SAM_GAREM 
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SAM domain of GAREM subfamily
SAM (sterile alpha motif) domain of GAREM (Grb2-associated and regulator of Erk/MARK) protein subfamily (also known as FAM59A) is a putative protein-protein interaction domain. SAM domain is a widespread domain in signaling proteins. Proteins of this group have SAM at the C-terminus. Human GAREM protein is known to play a role in regulation of the EGF (Epidermal Growth Factor) receptor and of Gab or insulin preceptor substrate-1 family proteins. Grb2 (Growth factor receptor-bound) protein was identified as a binding partner of human GAREM. Proline-rich motifs and phosphorylation of two conserved tyrosines in GAREM are important for the interaction with the SH3 domains of Grb2 protein; however these motifs and residues do not belong to the SAM domain.
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Statistics
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PSSM-Id: 188924
Aligned: 5 rows
Threshold Bit Score: 113.785
Created: 10-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DKZ_A        15 LSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGSGP 81  human
XP_419182    815 LSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKILQFINGWRP 881 chicken
NP_001084891 808 LSGLSVEEVSKSLRFIGLSEDVVSFFVSEKIDGNLLVQLTEEILSEDFKLSKLQVKKLLQFINGWRP 874 African clawed frog
NP_956463    799 LSGISIEEISKSLRFIGLSEDVVSLFVQEKIDGNLLLQLTEEILSEDFKLSKLQVKKLMQFINGWRP 865 zebrafish
XP_002593549 569 LSTLTVQEVSQCLRYIGTPDNVVQQFFRERIDGQMLIQLDKDILSQEFRLSGLQTKKISEFINGWRP 635 Florida lancelet
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