3HCS,2ECI,2JMD,3HCT,5VNZ,5VO0,7L3L


Conserved Protein Domain Family
mRING-HC-C3HC3D_TRAF6
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cd16643: mRING-HC-C3HC3D_TRAF6 
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Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and similar proteins
TRAF6, also known as interleukin-1 signal transducer or RING finger protein 85 (RNF85), is a cytoplasmic adapter protein that mediates signals induced by the tumor necrosis factor receptor (TNFR) superfamily and Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) family. It functions as a mediator involved in the activation of mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulatory factor pathways, as well as in IL-1R-mediated activation of NF-kappaB. TRAF6 is also an oncogene that plays a vital role in K-RAS-mediated oncogenesis. TRAF6 contains an N-terminal domain with a modified C3HC3D-type RING-HC finger and several zinc fingers, and a C-terminal TRAF domain that comprises a coiled coil domain and a conserved TRAF-C domain.
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Statistics
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PSSM-Id: 438305
Aligned: 22 rows
Threshold Bit Score: 108.62
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C DClick to see conserved feature residue pattern help
Evidence:
  • Structure:2JMD; Homo sapiens TRAF6 binds two Zn2+ ions through its modified RING-HC finger, contacts at 4A.
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  • Comment:modified RING-HC finger (C3HC3D-type)
  • Comment:consensus of the typical C3HC4-type RING-HC finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #             #  #                
3HCS_A        18 KYECPICLMALREaVQTPCGHRFCKACIIKSIRDAg--hKCPVDNeiLLENQLFPDNFAK 75  human
2JMD_A         6 KYECPICLMALREaVQTPCGHRFCKACIIKSIRDAg--hKCPVDNeiLLENQLFPDNFAK 63  human
5VNZ_A        19 KYECPICLMGLRSaVQTPCGHRFCDSCIRKSIRDTg--qKCPVDNevLLEEQLFPDNFAK 76  zebrafish
5VO0_A        19 KYECPICLMGLRSaVQTPCGHRFCDSCIRKSIRDTg--qKCPVDNevLLEEQLFPDNFAK 76  zebrafish
ABC73694      90 KYDCPICLLVLRDpYQTECGHRFCQNCIKRWLRETesepRCPVDNapLGEGQIFPDNFAK 149 Azumapecten farreri
ABN04154      51 KYECPICLMGLREpVQTNCGHRFCRYCILKSIRDAg--aRCPVDNtpLTEEQIFPDNFAK 108 Belcher's lancelet
Q6IWL4        68 KYECPICLMGLRSaVQTPCGHRFCDSCIRKSIRDTg--qKCPVDNevLLEEQLFPDNFAK 125 zebrafish
AHA83604      35 KYECPICLMCLRDpWQTGCGHRFCKSCIQRSLREAg--pRCPVDNapLTEQTMFPDQFAK 92  Japanese sea cucumber
XP_006816048  21 KYECPICLMALREpTQTQCGHRFCRSCICQSMRETg--sKCPIDNtpLSFSSLFPDNFAK 78  Saccoglossus kowalevskii
CRI06483      35 KYECPICLLALRApLQTACGHRFCKDCIYNSLSESs--rRCPIDNtpLKETDLFPDSCAE 92  green mud crab

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