2OXC


Conserved Protein Domain Family
DEADc_DDX20
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cd17943: DEADc_DDX20 
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DEAD-box helicase domain of DEAD box protein 20
DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350701
Aligned: 13 rows
Threshold Bit Score: 294.557
Created: 30-Jan-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2OXC; Homo sapiens DDX20 with bound ADP, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # # #  #                 ########                                      
2OXC_A         35 VLEGLRaaGFERPSpVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLvlen------------------------ 90   human
XP_001943847   34 ILKGLSdcGFTNASpIQVAALPTIIAGHDTIVEAKNGTGKTLTFVIPTLMRLkleq------------------------ 89   pea aphid
EFV52429      325 FLKGLTrmKFFAPSpIQAKAIPVGFAGHDMIVQSKSGTGKTCVFSILAVHMVrkea------------------------ 380  Trichinella s...
EFX89413       43 VLEGLNknGYLKPSpIQLEAIPIGKCGIDMVIQSKSGTGKTLVFGIVMLESIdlei------------------------ 98   common water ...
EDW33488       36 VMRGLAaeNFRTPTkIQAAAIPIALTGMDLLVQSKSGTGKTLIYVVTALQMCslst------------------------ 91   Drosophila pe...
ABO96695       48 LTRALRaaGFDAPSpVQLACVPLGRFGCDVIAQAKSGTGKTMTFVVIALERVdagr------------------------ 103  Ostreococcus ...
P0C218         37 VLEGLSasGFQRPSpIQLKAIPLGRCGLDLIVQAKSGTGKTCVFTTIALDSLilen------------------------ 92   zebrafish
ADY41899       30 SVDALTkaGFIYPSpVQAAAIPIGLMGFDMLVQAKSGTGKTLVFALMALEGLnaqr------------------------ 85   pig roundworm
EGI66684        7 ILDGLMsaGFQKPSpIQLKAIPLGRYGFDLIVRAKSGTGKTIVFGVIALDILdilv------------------------ 62   Panamanian le...
NP_524019      36 LLNGLKrnNFVTPTkIQAAAIPMALAKMDLIIQSKSGTGKTLIYVIAVVQSFnpni------------------------ 91   fruit fly
CAM36366       33 TLERLKnsQFDRPSpVQARAIPVGLLGRDMLVQAKSGTGKTLVFSVLAVENLdsrs------------------------ 88   nematode
Q54ZI9         66 VLKGLEdgGYQRPSpIQLKAIPLGISGVDLIAQAKSGTGKTIVFGVIALECVlreskllrqkqelnktqltnqtnkqlle 145  Dictyostelium...
EGG22524       87 LVEALKscGFEKPSpVQVQAIPIGVSGVDMVAQAKSGTGKTVVFGSIAIERVlrhctqptastlskkqll---------d 157  Dictyostelium...

Feature 1                                                                                         
2OXC_A         91 --------------lstQILILAPTREIAVQIHSVITAIgik--------megLECHVFIGG-------------TPLSQ 135  human
XP_001943847   90 --------------vhlQTIILAPTREIAVQIQQCFKKVgqh--------lpeLKCEYFIGG-------------TPVDV 134  pea aphid
EFV52429      381 -------------dsgvQVIIVTPTCEIAIQIQHVIDQIahf--------dehLKCQFFSGKf------------RSLLL 427  Trichinella s...
EFX89413       99 --------------stvQGLILAPTREIAFQNAHVIYTIgse--------lpgLNVQVFIGG-------------LPVDT 143  common water ...
EDW33488       92 --------------qhpEVLVILPTRELALQVHDTFRFLgek--------lrsFKVSSFMGG-------------TDVTR 136  Drosophila pe...
ABO96695      104 --------------rrtQALALAPTRECAVQTHECFVEMiekfkdmdgdarggIETCLLVGG-------------LPVKE 156  Ostreococcus ...
P0C218         93 --------------attQVLVLAPTREIAVQIHAVVMAIgsa--------megLECHVFIGG-------------RPISQ 137  zebrafish
ADY41899       86 --------------rqpQVMIIAPTREIAMQIAVTVRRLap----------pvIHVGVFVGGg------------RSVAD 129  pig roundworm
EGI66684       63 --------------gspQVLIIAPTREIAIQITYVIKTIgsk--------iegLRVEYFVGG-------------ISIEE 107  Panamanian le...
NP_524019      92 --------------nqpHAMIVVPTRELAIQVQDTFFHLcks--------frdFKCSAFIGG-------------TDVAK 136  fruit fly
CAM36366       89 --------------shiQKVIVTPTREISVQIKETVRKVap----------tgARTSVYVGG-------------SAHKL 131  nematode
Q54ZI9        146 mdddtyvetmvgiirkpLVLIIAPTREIAVQIKDVIKSIsky--------ckrIKCEVFIGGlnsnnnkdennnnILNNE 217  Dictyostelium...
EGG22524      158 mdddsyaeavsgvprrtLVLMLAPTREIAIQIASVVGEIakha-------gkrLHVEAFVGGn-----------aSTTQE 219  Dictyostelium...

Feature 1                                                                                         
2OXC_A        136 DKTRLK--KCHIAVGSPGRIKQLIELdylNPGSIRLFILDEADKLLe---eGSFQEQINWIYSSLPa------------S 198  human
XP_001943847  135 DKEKAK--CCQIAVGSPGRIKHLINEhvlKCSEVKSFILDEVDRLVt---dKSFTKDVRLIDAKLPk------------L 197  pea aphid
EFV52429      428 DKDELK--RCQIVVGTPGRLCHLVKLnaiSVERVRMLVFDEADRLMn----GTFQPTLNVLFNHLSa------------S 489  Trichinella s...
EFX89413      144 DLSKCK--SCHIAVGTPGRVKQLIEKnalKTKTIRLFILDEADKLMe----DSFADDVMWIFSQMQl------------T 205  common water ...
EDW33488      137 DREKLR--NCHVAIGTPGRLLQLHEKgvlNMSMVKLLVLDEADQLYv---tASLQKTVNALIAVLPl------------Q 199  Drosophila pe...
ABO96695      157 DRARLAs-QPHVVVGTPGRTRQMLEEgsmACDGARLLILDEADALLs----GTFERDVLFAYSMLPe------------R 219  Ostreococcus ...
P0C218        138 DKQHLK--KCHIAIGSPGRIKQLIEMgalMVSSIRLFVLDEADKLLeddssSSFQEQINWIYSSLPa------------N 203  zebrafish
ADY41899      130 DIKEIRk-GVHIAVGTTGRLCQLVNDdllPTNHVHLFVLDEADKLMe----ENFQKDINFLFSSLPn------------N 192  pig roundworm
EGI66684      108 DKKKLS--KCHIAVGAPGRVKHLIEKgflQVSKIKLFVLDEADKLMe----INFQKDINYIFSKLPs------------S 169  Panamanian le...
NP_524019     137 DRKRMN--ESRVIIGTPGRLLHLYENrvfDVSKLRLLVLDEADQLYq---tKSLQHTVSKLIEAMPk------------N 199  fruit fly
CAM36366      132 NLIDLKqtRPQIVIGTPGRIAQLVKLgamNMSHVDFFVLDEADKLMd----EVFRDDINIIINSLPq------------I 195  nematode
Q54ZI9        218 DVNRLN--GTQIIVGTPGKIKSLIENlhlRTDTLKMVIMDEADKLLd----ASFSKTINWIYSAIGngnsnknnsssgsG 291  Dictyostelium...
EGG22524      220 DEIKLG--GAQVVVGTPGRIRSLIEArrlRTDDIELFIMDEADKLLd----AAFSKDFNWIFTSLPk------------K 281  Dictyostelium...

Feature 1                                      
2OXC_A        199 KQMLAVSATYPEFLANALTKYMRDPTFVR 227  human
XP_001943847  198 KQTIVVSASIDKNDMSVFDEFMTEYIVVK 226  pea aphid
EFV52429      490 KQVVVTSATYPHAFCEMLKRYMRNPTFIS 518  Trichinella spiralis
EFX89413      206 KQVLAVSATYPEVLANLVSRYMQKPSFVR 234  common water flea
EDW33488      200 RQVIACSATFDQNLDEKIAKMMEKPVLIS 228  Drosophila persimilis
ABO96695      220 KQVCAFSATYSKTLLGDLERLMRAPQKVM 248  Ostreococcus lucimarinus CCE9901
P0C218        204 KQMLALSATYPESLAQQLSRYMREPTFVR 232  zebrafish
ADY41899      193 KQMAVFSATYPGDLDETLARYMKKAHLIR 221  pig roundworm
EGI66684      170 KQIIASSATYPGDLETFLQTYMSSPVLTS 198  Panamanian leafcutter ant
NP_524019     200 RQIIACSATYDQNLDERLAKVMDKPMLIS 228  fruit fly
CAM36366      196 RQVAVFSATYPRNLDNLLSTFLRDAALVR 224  nematode
Q54ZI9        292 IQMLAFSATYPSYLINLLKLYMNNENLVE 320  Dictyostelium discoideum
EGG22524      282 RQIAAFSATFPTALLNMVERYMSNPVHVQ 310  Dictyostelium fasciculatum

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