2YQM,2YW8


Conserved Protein Domain Family
FYVE_RUFY1
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cd15758: FYVE_RUFY1 
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FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
RUFY1, also termed FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homologue of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between.
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Statistics
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PSSM-Id: 277297
Aligned: 5 rows
Threshold Bit Score: 128.644
Created: 11-Jul-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2YQM; Homo sapiens ZFY12 binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #            #  #    #  #                #  #         
2YQM_A        15 LKGHAWLKDDEATHCRQCEKEFSIsRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCS 85  human
2YW8_A         8 LKGHAWLKDDEATHCRQCEKEFSIsRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCS 78  human
NP_001244198 618 LKGHTWLKDDEATHCKQCEKEFSIsRRKHHCRNCGDIFCNACSSNELALPSYPKPVRVCDSCHTLLLQRCS 688 chicken
NP_001121230 525 LKGHAWLKDDEAAECKQCNKEFSIsRRKHHCRNCGHIFCNSCSSNELSLPSYPKPVRVCDTCHNLLLQRCS 595 African clawed frog
XP_002667361 624 LKGHAWLKDDEATQCKQCQKEFSIsRRKHHCRNCGDIYCGNCSSNELALPSYPKPVRVCDVCHSLLLQRSS 694 zebrafish

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