2ZVO


Conserved Protein Domain Family
UBAN
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cd09803: UBAN 
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polyubiquitin binding domain of NEMO and related proteins
NEMO (NF-kappaB essential modulator) is a regulatory subunit of the kinase complex IKK, which is involved in the activation of NF-kappaB via phosporylation of inhibitory IkappaBs. This mechanism requires the binding of NEMO to ubiquinated substrates. Binding is achieved via the UBAN motif (ubiquitin binding in ABIN and NEMO), which is described in this model. This region of NEMO has also been named CoZi (for coiled-coil 2 and leucine zipper). ABINs (A20-binding inhibitors of NF-kappaB) are sensors for ubiquitin that are involved in regulation of apoptosis, ABIN-1 is presumed to inhibit signalling via the NF-kappaB route. The UBAN motif is also found in optineurin, the product of a gene associated with glaucoma, which has been characterized as a negative regulator of NF-kappaB as well.
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Statistics
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PSSM-Id: 197361
Aligned: 15 rows
Threshold Bit Score: 82.0119
Created: 27-May-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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polyubiquitindimer interface
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:polyubiquitin binding site [polypeptide binding site]
Evidence:
  • Structure:2ZVO: Mouse nemo cozi domain dimer binds polyubiquitin, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #   ## ##  ### ## ###  ##  ##  #          
2ZVO_B         4 MQLEDLRQQLQQAEEALVAKQELIDKLKEEAAQHAivmETVPVLKAQADIYKADFQAERHAREKLVEKKEYLQEQLEQLQ 83  house mouse
Q5RI56       358 DDYDELQTRFATAEKALADKQQKIDEMKMELFQKEkdlETISVFQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVK 437 zebrafish
NP_001088901 376 VEFNELLEKLDVCEKALAKKQFEIDEMREMDTKHEedkETIELLRAQVDVYCADFHAERSARENIHQEKEQLATRLAYMI 455 African clawed ...
Q8R5M4       425 VQLQELSEKLELAEQALASKQLQMDEMKQTIAKQEedlETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILL 504 Norway rat
NP_989567    400 VVVEELNAKVLLAEQALAAKQLQMDEMKQLIAKQEedlETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLAVQLAYLL 479 chicken
EEB12832     424 GDINSLVIELNEKDEKLKSKEDECEKLKESIANLNlecEKIPVLKVQAELYESDFKDEREAREKLVGEKEKMAEQIRILQ 503 human body louse
AAY27979     251 GKIDHLTAQLIAAEESLSLKNQTLENLQEKIKKCTaenDDIPLLRAQADIYKSDFDAERAAHEKEHQENKKLKEDLQNIE 330 Euprymna scolopes
Q96CV9       421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEedlETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLL 500 human
EDW73937     235 DEINCLKVNLTCAEELVGRMQRDIQELKTNDAQQR---EQIAYLQTQNDIYRRDFEMERADREKNAGEKEQYLMDLRDLQ 311 Drosophila will...
Q9GYV5       230 FEFVPEYATESKSQELIKKMQLDINELKARDIQKQ---EVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQ 306 fruit fly

Feature 1               
2ZVO_B        84 REFNKLK 90  house mouse
Q5RI56       438 KQNSQLQ 444 zebrafish
NP_001088901 456 QEYEKLK 462 African clawed frog
Q8R5M4       505 KENNDFE 511 Norway rat
NP_989567    480 KEQQNLE 486 chicken
EEB12832     504 TKLENLN 510 human body louse
AAY27979     331 LQNRELL 337 Euprymna scolopes
Q96CV9       501 KENDAFE 507 human
EDW73937     312 RRNQKLI 318 Drosophila willistoni
Q9GYV5       307 RRNQELI 313 fruit fly

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