1AE4,1HQT,1CWN,3CV7,4GAC,2ALR


Conserved Protein Domain Family
AKR_AKR1A1-4
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cd19106: AKR_AKR1A1-4 
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AKR1A family of aldo-keto reductase (AKR)
The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Links
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Statistics
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PSSM-Id: 381332
Aligned: 22 rows
Threshold Bit Score: 545.828
Created: 12-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1AE4: Sus scrofa aldehyde reductase holoenzyme in complex with inhibitor and cofactor NADP; contacts at 4A.
  • Citation:PMID 7552731
  • Citation:PMID 9329083
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                      #    #                             # #     
1AE4_A         8 LHTGQKMPLIGLGTWKSePGQVKAAIKYALTVGYRHIDCAAIYGNELEIGEALTETvgpgkavpREELFVTSKLWNTKHh 87   pig
XP_014344577  10 LNNGKKMPLIGLGTWKSsPGQVGSAVKYALDVGYCHIDCATVYENEPEIGQVFQEKvgpgkaikREDLFVTSKLWNTKHh 89   coelacanth
XP_007898081   9 LHTGQKMPLIGLGTWKSePGQVQEALQHSLEIGYRHIDCAAVYNNEAEIGHTLQEKvgidkpvsREDIFVTSKLWNTKHh 88   elephant shark
Q6AZW2         7 LSTGQRMPTVGLGTWKSaPGQVKQAVLAALDCGYRHIDCAAAYSNEREVGEALTERlgpgkslrRDDIFVTSKLWNTKHh 86   zebrafish
Q6GMC7        10 LYTGQKMPLIGLGTWKSaPGQVKDAVKYALGVGYRHIDCAFVYGNETEVGEAIKESvgpdkglkREEVFVTSKLWNNKHh 89   African clawed...
Q568L5         7 LSTGRKMPLLGLGTWKSePGLVKQAVIWALESGYRHIDCAPIYANEPEIGEAFQETmgpdkgirREDVFVTSKLWNTKHh 86   zebrafish
XP_003386238  52 LFDGQQIPLVGLGTWKSkPGQVESAVSVALDAGYKLIDGAHVYGNEQEVGNALKEKiga--glnRKDLFIVSKLWNTKHr 129  Amphimedon que...
ELU06173       8 LSSGIDMPILGLGTWKSkPGEVENAVKAAIDAGYRHLDCAWIYGNEQEVGAALKSKideg-vvkREDLFITSKIWNTKHr 86   Capitella teleta
XP_002741648   7 LFSGVELPLVGLGTWKSkPGEVQNAVKSAFSCGYRHIDCAACYGNEKEVGDAFKETigs--vveRKDVFITSKLWNTKHa 84   Saccoglossus k...
KXJ19248      87 LNSGYRMPLVGLGTWKSkPGQVKNAVMVAIDAGYRHIDCAYMYGNETEVGEALKEKigt--vvdRKDLFITSKLWNTKHc 164  Exaiptasia pal...

Feature 1                                 ##                                                 ##  
1AE4_A        88 pEDVEPALRKTLADLqLEYLDLYLMHWPYAFerg--dnpFPKNADGTIRYdathYKDTWKALEALVAKGLVRALGLSNFS 165  pig
XP_014344577  90 pDDVEPSVRKTLQDLkLDYLDLYLIHWPHGFerg--dilFPNNPDGSIRYdytdFKETWKAMEKLVEKGLVKTIGLSNFN 167  coelacanth
XP_007898081  89 pEDVEPSCRKSLKDLkLTYLDLYLIHWPHGFerg--diaFPKNPDDTMRYdyvdYKETWKAMEKLVDKGLVKAIGLSNFN 166  elephant shark
Q6AZW2        87 pDDVEEACRRSLSDLrLSYLDLYLIHWPMAFgrg--delIPRHPDGTIQYddthYRDTWAAMEKLVDQGLAKAIGLSNFN 164  zebrafish
Q6GMC7        90 pDDVECALRKTLQELqLDYLDLYLMHWPYAFkrg--dqvFPQNPDGSVQYdltdYKDTWKAMEKLVEKGLAKAIGLSNFN 167  African clawed...
Q568L5        87 pDDVEPSLLKTLKDLkLEYLDLYLIHWPYAFqrg--dtpFPRKEDGTLLYddidYKLTWAAMEKLVGKGLVRAIGLSNFN 164  zebrafish
XP_003386238 130 eSDVRPALLNTLKDLqLDYIDLYLIHWPISFvpg--dnkFPKNPDGSMQYdsvpPLETWRAMEKLVDEGLVRYIGLSNFN 207  Amphimedon que...
ELU06173      87 fEDALTNIKQSLSNLgISYLDLSLIHWPTSMkhdgncdkFPRDDQGNVQHtnvsYLETWKALEKAMDDGLVKAIGLSNFN 166  Capitella teleta
XP_002741648  85 aVDVKPACIESLKDLqLDYLDLYLIHWPYGFvni--genFPKNPDGTIQYsdvsLMETWGAMEKLVDEGLCKHIGLSNCN 162  Saccoglossus k...
KXJ19248     165 pSDVRNACLQTLKDLqLDYVDLYLIHSPVSFksg--derFPKDENNKILFayydPCNTWKAMEELVDEGLVKSIGISNFN 242  Exaiptasia pal...

Feature 1                          #                         ########                            
1AE4_A       166 SRQIDDVLSVAsvRPAVLQVECHPYLaQNELIAHCQARgLEVTAYSPLGSSDRAWrdpnEPVLLEEPVVQALAEKYNRsP 245  pig
XP_014344577 168 SRQIDEIIGIAtiKPAVLQVECHPYLvQSELLAHCQSRgLVMTAYSPLGSPDRAWrrpeEPVVLEEPRIKTLADKYSKsP 247  coelacanth
XP_007898081 167 SRQIDDIINIAtiKPAVLQVECHPYLaQNELIAHCQKRgLVVTAYSPLGSPDRMWrkadEPVLLEEPSIVSLGKKYGKsP 246  elephant shark
Q6AZW2       165 AKQIDDILSIAkhKPVVNQVECHPYLvQAELVSHCWSRnLTVTAYSPLGSPDRPWvtpgEALLLDDPRVVGIAKSYNKtP 244  zebrafish
Q6GMC7       168 KRQMDDILSIAtvKPAVLQVECHPYLaQNELIACCRSHgLVLTGYSPLGSPDRSWrkpeDPVLLEEPGIIAMAKKYNIsE 247  African clawed...
Q568L5       165 SRQIDDILSVAsiKPTVLQVESHPYLaQVELLSHCRDRgLVMTAYSPLGSPDRAWkhpdEPVLLEEPAIAALAKKYNKtP 244  zebrafish
XP_003386238 208 SQQVDEIMSNCriQPAVLQCEAHPYLnQQRLLDHISKYkIVFQAYSPLGSPDRPWarsgEPVLLDNPTVAEIGKRYNKsV 287  Amphimedon que...
ELU06173     167 SRQIGEIISNAriQPSVLQVEIHPYFtQEKLVHFCKERnIVVTAYSPLGSPDRPWaapgEPLLLEDPKLIEIAKKYSKsP 246  Capitella teleta
XP_002741648 163 SKQVAEVLEKGriKPAVLQVECHPYFnQERLINFCKEKdIVVTASSPLGSPDRPWakssDIILVEEPTLKAIGDKYKKsP 242  Saccoglossus k...
KXJ19248     243 SKQVTDICNIAriTPAVNQVECHPYLtQVPLIEHCKKLcVLISAFSPLGSPDRPWakpgDPSLLDDPKLTAIAKKYXKsT 322  Exaiptasia pal...

Feature 1        #              ######  #   #                             #           
1AE4_A       246 AQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNl--RFIVPMLTVDGKRVPR 312  pig
XP_014344577 248 AQVILRWLIQRGVVTIPKSVTPSRIQENFQVFDFALTQEEVKTIDGLNRNc--RYILPMIEVDGKLVAR 314  coelacanth
XP_007898081 247 AQVVLRWQVQRGVIAIPKSVNPARIAQNIQVFDFTLTEDEIKIIGSLDRNw--RYIVPLITVDGKSVPR 313  elephant shark
Q6AZW2       245 AQVIIRWHIQRGVVCIPKSVTPSRIKQNIEVFDFKLSDEDMRLIESFNRNe--RFIIPTVIKDGQKIWR 311  zebrafish
Q6GMC7       248 AQILLRWQVQRRVVTIPKSVTPARILQNLQVFDFSLSEEEMQLIGALNKNw--RYIIPLITVNGKSVPR 314  African clawed frog
Q568L5       245 AQIIIRWQTQRGVVTIPKSITQSRIKENIQVFDFTLESEEMSQVTALHRGw--RYIVPTITVDGKSVPR 311  zebrafish
XP_003386238 288 AQVLIRFQVERGVVVIPKSVTPERIRSNFDVFDFKLTQEEMQTLLGLETNw--RACLPTIEVDGKQVPR 354  Amphimedon queenslandica
ELU06173     247 AQVIIRWLMQRGIAVIPKSVTPSRIIENFNVRDFKLTADDMNVVSGFNRNh--RLVCPSITVNGVRQFR 313  Capitella teleta
XP_002741648 243 AQVALRFNVQRGVVVIPKSITPARIAQNLEVCDFELSAEDMKKIESLHNEatgRVCVPAIEVDGKRVPR 311  Saccoglossus kowalevskii
KXJ19248     323 AQICIKFQVQRGIPVLPKSVTPSRIKENFDVFDFEMTDDEMSILEAFNRNw--RCFMPCVEELAVRLTD 389  Exaiptasia pallida

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