Conserved Protein Domain Family
IPT_COE
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cd01175: IPT_COE 
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.
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Statistics
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PSSM-Id: 238580
Aligned: 5 rows
Threshold Bit Score: 167.44
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O73742 264 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTML-VWS---ELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKG 339 African clawed frog
Q63398 255 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTML-VWS---ELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKG 330 Norway rat
O93375 260 PCIKAISPSEGWTTGGAMVIVIGENFFDGLQVVFGSML-VWS---ELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKG 335 zebrafish
P56721 299 PCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGTML-VWS---ELITSHAIRVQTPPSDIPGVVEVTLSYKSKQFCKG 374 fruit fly
Q93705 269 PVIKALFPSEGWIQGGTQVVLIGENFFEGLQVAFGTASpNWGesvQLISPHAIRVTTPPKHSAGPVDVTLQYKSKTYSRG 348 Caenorhabditis elegans

O73742 340 APGRFVYTA 348 African clawed frog
Q63398 331 TPGRFIYTA 339 Norway rat
O93375 336 APGRFIYTA 344 zebrafish
P56721 375 SPGRFVYVS 383 fruit fly
Q93705 349 TPLRFSYIT 357 Caenorhabditis elegans
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