2WQ9,1RLB,1KT3,1KT7,1AQB,3BSZ,1BRP,1IIU,1QAB


Conserved Protein Domain Family
lipocalin_RBP_like

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cd00743: lipocalin_RBP_like 
retinol-binding protein 4 and similar proteins
Retinol-Binding Protein 4 (RBP4) is a plasma protein that transports retinol (vitamin A) from the liver stores to the peripheral tissues. The RBP4-retinol complex interacts with transthyretin (TTR - transports thyroxine and retinol) which protects it from renal excretion. In addition to retinol, other endogenous and synthetic retinoids bind RBP4, including all-trans and 13-cis retinoic acid, retinyl acetate, N-(ethyl)retinamide, and fenretinide. This group also includes purpurin, a retinol-specific protein that plays a role in neural retina cell adhesion during development of the chicken retina; it also binds retinol and may participate in retinol transporter in the retina. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381184
Aligned: 16 rows
Threshold Bit Score: 326.326
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:retinol binding site [chemical binding site]
Evidence:
  • Structure:1IIU; chicken plasma retinol-binding protein bound with retinol, contacts 4A
  • Structure:1BRP; Homo sapiens RBP4 with bound retinol, contacts at 4A
  • Citation:PMID 8464067

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              #  #  ###     # #         ###   # #         ### #      
2WQ9_A      4 CRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDEtGQMSATAKGRVRLLNNWDVCADMVGTFTDTe-- 81  human
1AQB_A      4 CRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDEnGHMSATAKGRVRLLNNWDVCADMVGTFTDTe-- 81  domestic pig
3BSZ_E      4 CRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDEtGQMSATAKGRVRLLNNWDVCADMVGTFTDTe-- 81  human
1BRP_A      4 CRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDEtGQMSATAKGRVRLLNNWDVCADMVGTFTDTe-- 81  human
1IIU_A      3 CRVSSFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDEnGQMSATAKGRVRLFNNWDVCADMIGSFTDTe-- 80  chicken
131649     24 CAVDSFSVKDNFDPKRYAGKWYALAKKDPEGLFLQDNISAEYTVEEdGTMTASSKGRVKLFGFWVICADMAAQYTVPdpt 103 chicken
NP_956259  24 CAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDdGTMTASSKGRVTLFGFWVVCADMAAQYSVPdpt 103 zebrafish
132408     24 CRVDNFEVMKDFNKERYAGVWYAVAKKDPEGLFLLDNIAANFKIEDnGKTTATAKGRVRILDKLELCANMVGTFIETn-- 101 African clawed frog
267584      3 CQVSNIQVMQNFDRSRYTGRWYAVAKKDPVGLFLLDNVVAQFSVDEsGKVTATAHGRVIILNNWEMCANMFGTFEDTp-- 80  rainbow trout
AFK11414   26 CNVSTFPVKENFNKTRYLGRWYAMAKKSPDSIFLEDNIYADFAQDDqGFMNATARGRVTLLENWPTCVQMLGKFLETs-- 103 ghost shark
Feature 1           # #     ###   # #            #   #           # # #                        
2WQ9_A     82 dPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNlDGTCADSYSFVFSRDpnGLPPEAQKIVRQRQEELCL 161 human
1AQB_A     82 dPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLQNlDGTCADSYSFVFARDphGFSPEVQKIVRQRQEELCL 161 domestic pig
3BSZ_E     82 dPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNlDGTCADSYSFVFSRDpnGLPPEAQKIVRQRQEELCL 161 human
1BRP_A     82 dPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNlDGTCADSYSFVFSRDpnGLPPEAQKIVRQRQEELCL 161 human
1IIU_A     81 dPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNeDGTCADSYSFVFSRDpkGLPPEAQKIVRQRQIDLCL 160 chicken
131649    104 tPAKMYMTYQGLASYLSSGGDNYWVIDTDYDNYAITYACRSLKeDGSCDDGYSLIFSRNprGLPPAIQRIVRQKQEEICM 183 chicken
NP_956259 104 tPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKdDGSCDDGYSLVFSRNprGLPPAIQRLVRQKQDEICM 183 zebrafish
132408    102 dPAKYRMKYHGALAILERGLDDHWVVDTDYTTYAITYACRRRNlDGTCRDSYSFVFSRDinGLPSESQRIVRRRQEQLCL 181 African clawed frog
267584     81 dPAKFKMRYWGAASYLQTGNDDHWVIDTDYDNYAIHYSCREVDlDGTCLDGYSFIFSRHptGLRPEDQKIVTDKKKEICF 160 rainbow trout
AFK11414  104 nPAKFKLKYRGALHYLQSGFDDHWVIDTDYDTFAITYTCRQLNdDETCADSYSLVFSRDpkGIPPGVHGIIRQRQGQICL 183 ghost shark
Feature 1                  
2WQ9_A    162 arQYRLIVHNGYC 174 human
1AQB_A    162 arQYRIITHNGYC 174 domestic pig
3BSZ_E    162 arQYRLIVHNGYC 174 human
1BRP_A    162 arQYRLIVHNGYC 174 human
1IIU_A    161 drKYRVIVHNGFC 173 chicken
131649    184 sgQFQPVLQSGAC 196 chicken
NP_956259 184 agQFQPVLQSGAC 196 zebrafish
132408    182 drKYRVVVHNGYC 194 African clawed frog
267584    161 lgKYRRVGHTGFC 173 rainbow trout
AFK11414  184 anKYGRVRHEGLC 196 ghost shark

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