3QBY,3EAE


Conserved Protein Domain Family
PWWP_HDGFL2

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cd20149: PWWP_HDGFL2 
Click on image for an interactive view with Cn3D
PWWP domain found in Hepatoma-derived growth factor-related protein 2 (HDGFL2)
HDGFL2, also called HDGF-related protein 2 (HRP-2), or Hepatoma-derived growth factor 2 (HDGF-2), is involved in cellular growth control, through the regulation of cyclin D1 expression. It contains a PWWP domain, which is necessary for DNA binding.
Statistics
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PSSM-Id: 438977
Aligned: 9 rows
Threshold Bit Score: 157.757
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structures of human HRP3 and rat HDGF domains with bound DNA

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # ## #                                                       # #       
3QBY_A         6 FKPGDLVFAKMKGYPHWPARIDDIAd---GAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGL 82  human
3EAE_A         5 FKPGDLVFAKMKGYPHWPARIDDIAd---GAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGL 81  human
Q7Z4V5         5 FKPGDLVFAKMKGYPHWPARIDDIAd---GAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGL 81  human
Q32N87         5 FKPGDLVFAKMKGYPHWPARIDDVKd---GAVKPPPNKCPIFFYGTHETAFLAPKDLFPYDKYKDKYGKPNKRKGFNEGL 81  African clawed ...
Q5XXA7         5 FRPGDLVFAKMKGYPHWPARIEDVAd---GAVKPPPNKIPIFFFGTHETAFLAPKDLFAYEKNQERFGKPNKRKGFNEGL 81  zebrafish
OXB61636       5 FKPGDLVFAKMKGYPHWPARIDDIAd---GAVKPPPNKYPIFFFGTHETAFLGPKDLFPYEKYKDKYGKPNKRKGFNEGL 81  scaled quail
XP_005993831   5 FKSGDLVFAKMKGYPHWPARIDDIAd---GAVKPPPNKYPIFFYGTHETAFLGPKDLFPYDKYKDKYGKPNKRKGFNEGL 81  coelacanth
XP_007899345   5 FKPGDLVFAKMKGYPHWPARIDDVAe---GAVKPPSNKYPIFFYGTHETAFLGPKDIFAFEKYKDKYGKPNKRKGFNEGL 81  elephant shark
NP_001161563   7 FKPGDKIFAKMKGYPHWPARVSVIDdiqeGAVKPPANKFPIFFYGTHETAFLSAKELFPYAKFKDKFGKPNKRRGFNEGL 86  Saccoglossus ko...
Feature 1               
3QBY_A        83 WEIQNNP 89  human
3EAE_A        82 WEIQNNP 88  human
Q7Z4V5        82 WEIQNNP 88  human
Q32N87        82 WEIQNNP 88  African clawed frog
Q5XXA7        82 WEIQNNP 88  zebrafish
OXB61636      82 WEIQNNP 88  scaled quail
XP_005993831  82 WEIQNNP 88  coelacanth
XP_007899345  82 WEIENNP 88  elephant shark
NP_001161563  87 WEIENKP 93  Saccoglossus kowalevskii

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