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vipb vasoactive intestinal peptide b [ Danio rerio (zebrafish) ]

Gene ID: 100000558, updated on 2-Nov-2024

Summary

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Official Symbol
vipbprovided by ZNC
Official Full Name
vasoactive intestinal peptide bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080225-22
See related
Ensembl:ENSDARG00000079443 AllianceGenome:ZFIN:ZDB-GENE-080225-22
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vip2; im:7156614
Summary
Predicted to enable neuropeptide hormone activity. Predicted to be involved in mRNA stabilization and prolactin secretion. Predicted to be located in extracellular region. Is expressed in enteric neurons; hindbrain; and posterior intestine. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See vipb in Genome Data Viewer
Location:
chromosome: 11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (43401590..43414038)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (43109377..43121777)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496738 Neighboring gene sulfotransferase family, cytosolic, 6b, member 1 Neighboring gene solute carrier family 29 member 1b Neighboring gene transmembrane protein 63Bb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In toto imaging of early enteric nervous system development reveals that gut colonization is tied to proliferation downstream of Ret. Baker PA, et al. Development, 2022 Nov 1. PMID 36300492, Free PMC Article
  2. High fat diet induces microbiota-dependent silencing of enteroendocrine cells. Ye L, et al. Elife, 2019 Dec 3. PMID 31793875, Free PMC Article
  3. An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. Howard AG 4th, et al. Elife, 2021 Feb 16. PMID 33591267, Free PMC Article
  4. Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. Lavergne A, et al. BMC Biol, 2020 Aug 31. PMID 32867764, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in prolactin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vasoactive intestinal peptide b
Names
vasoactive intestinal polypeptide type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114555.1 → NP_001108027.1  vasoactive intestinal peptide b precursor

    See identical proteins and their annotated locations for NP_001108027.1

    Status: PROVISIONAL

    Source sequence(s)
    EU031790
    UniProtKB/TrEMBL
    B0LF71
    Related
    ENSDARP00000098318.1, ENSDART00000112468.4
    Conserved Domains (1) summary
    pfam00123
    Location:76 → 102
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    43401590..43414038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479523.2 → XP_021335198.1  vasoactive intestinal peptide b isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q6Y9
    Conserved Domains (1) summary
    pfam00123
    Location:76 → 102
    Hormone_2; Peptide hormone
Nucleotide Protein Strain
Heading Accession and Version

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