tmem63c transmembrane protein 63C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmem63cprovided by ZNC
Official Full Name: transmembrane protein 63Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120928-2
See related: Ensembl:ENSDARG00000004158 AllianceGenome:ZFIN:ZDB-GENE-120928-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-7i21.1; si:dkey-120l3.1
Summary: Predicted to enable calcium-activated cation channel activity and osmolarity-sensing monoatomic cation channel activity. Involved in glomerular filtration. Acts upstream of or within glomerulus development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87. Orthologous to human TMEM63C (transmembrane protein 63C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (44780374..44923466)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (44666441..44809701)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables osmolarity-sensing monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium permeable stress-gated cation channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159836.1 → NP_001153308.1 calcium permeable stress-gated cation channel 1

See identical proteins and their annotated locations for NP_001153308.1

Status: PROVISIONAL

Source sequence(s)

AL953899

UniProtKB/TrEMBL

B0R175

Related

ENSDARP00000069288.4, ENSDART00000074802.5

Conserved Domains (3) summary

pfam02714
Location:436 → 691

RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

pfam13967
Location:120 → 212

RSN1_TM; Late exocytosis, associated with Golgi transport

pfam14703
Location:231 → 409

PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

44780374..44923466

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158882.5 → XP_005158939.1 calcium permeable stress-gated cation channel 1 isoform X1

UniProtKB/Swiss-Prot

X1WEM4

Related

ENSDARP00000128675.1, ENSDART00000156260.3

Conserved Domains (3) summary

pfam02714
Location:440 → 695

RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

pfam13967
Location:120 → 216

RSN1_TM; Late exocytosis, associated with Golgi transport

pfam14703
Location:235 → 413

PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
XM_068214295.1 → XP_068070396.1 calcium permeable stress-gated cation channel 1 isoform X2