bcl6ab BCL6A transcription repressor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bcl6abprovided by ZNC
Official Full Name: BCL6A transcription repressor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7523
See related: Ensembl:ENSDARG00000069295 AllianceGenome:ZFIN:ZDB-GENE-030131-7523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj23a05; wu:fj23a05; wu:fv66b06
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10087334..10098191, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10289512..10300387, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BCL6A transcription repressor b

Names: B cell CLL/lymphoma 6ab; B-cell CLL/lymphoma 6a, genome duplicate b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100074.1 → NP_001093544.1 BCL6A transcription repressor b

Status: PROVISIONAL

Source sequence(s)

CU104710

UniProtKB/TrEMBL

A0A8M1NFA1, A5WWI3

Related

ENSDARP00000116903.1, ENSDART00000138081.2

Conserved Domains (4) summary

smart00225
Location:33 → 128

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:440 → 460

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 126

BTB; BTB/POZ domain

pfam13465
Location:452 → 477

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

10087334..10098191 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171137.4 → XP_005171194.1 BCL6A transcription repressor b isoform X1

UniProtKB/TrEMBL

A0A8M2BIF1

Conserved Domains (4) summary

smart00225
Location:33 → 128

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:441 → 461

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 126

BTB; BTB/POZ domain

pfam13465
Location:453 → 478

zf-H2C2_2; Zinc-finger double domain