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zbtb18 zinc finger and BTB domain containing 18 [ Danio rerio (zebrafish) ]

Gene ID: 100003157, updated on 2-Nov-2024

Summary

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Official Symbol
zbtb18provided by ZNC
Official Full Name
zinc finger and BTB domain containing 18provided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-73
See related
Ensembl:ENSDARG00000028228 AllianceGenome:ZFIN:ZDB-GENE-050419-73
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
znf238; si:ch211-221n23.1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; optic cup; and somite. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See zbtb18 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (11436406..11445034)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (11307939..11310460)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SHH signaling and ciliogenesis regulator sdccag8 Neighboring gene v-akt murine thymoma viral oncogene homolog 3a Neighboring gene uncharacterized LOC137487332 Neighboring gene uncharacterized LOC137487369 Neighboring gene adenylosuccinate synthase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Diotel N, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26107416
  2. Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. Al Qaryoute A, et al. Sci Rep, 2023 Sep 26. PMID 37752184, Free PMC Article
  3. A single cell transcriptome atlas of the developing zebrafish hindbrain. Tambalo M, et al. Development, 2020 Mar 16. PMID 32094115, Free PMC Article
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 18
Names
BTB/POZ domain protein ZF238
novel zinc finger domain containing protein
zinc finger protein 238

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082952.2 → NP_001076421.2  zinc finger and BTB domain-containing protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR589882
    UniProtKB/Swiss-Prot
    Q1L8W0, Q4JEX7
    Related
    ENSDARP00000141791.1, ENSDART00000169895.2

  2. NM_001423910.1 → NP_001410839.1  zinc finger and BTB domain-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR589882

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    11436406..11445034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224871.1 → XP_068080972.1  zinc finger and BTB domain-containing protein 18 isoform X4

  2. XM_068224870.1 → XP_068080971.1  zinc finger and BTB domain-containing protein 18 isoform X4

    Related
    ENSDARP00000144804.1, ENSDART00000186463.1

  3. XM_068224869.1 → XP_068080970.1  zinc finger and BTB domain-containing protein 18 isoform X3

  4. XM_068224867.1 → XP_068080968.1  zinc finger and BTB domain-containing protein 18 isoform X1

  5. XM_068224868.1 → XP_068080969.1  zinc finger and BTB domain-containing protein 18 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1L8W0.1 GenPept UniProtKB/Swiss-Prot:Q1L8W0

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